Hepatitis C–associated hepatocellular carcinoma
Article first published online: 6 DEC 2005
Copyright © 1990 American Association for the Study of Liver Diseases
Volume 12, Issue 3, pages 589–591, September 1990
How to Cite
Hasan, F., Jeffers, L. J., De Medina, M., Reddy, K. R., Parker, T., Schiff, E. R., Houghton, M., Choo, Q. and Kuo, G. (1990), Hepatitis C–associated hepatocellular carcinoma. Hepatology, 12: 589–591. doi: 10.1002/hep.1840120323
- Issue published online: 6 DEC 2005
- Article first published online: 6 DEC 2005
- Manuscript Accepted: 23 MAR 1990
- Manuscript Received: 12 OCT 1989
In the United States, a large percentage of patients with hepatocellular carcinoma are serologically negative for hepatitis B. We conducted a retrospective study to determine the prevalence of hepatitis C antibody in the sera of 59 patients with hepatocellular carcinoma who were HBsAg-negative and had no evidence of alcoholic liver disease, primary biiary cirrhosis, autoimmune hepatitis, hemochromatosis or α1-antitrypsin deficiency. Twenty patients (34%) were hepatitis C antibody-positive and hepatitis B core antibody-negative. All twenty patients had underlying cirrhosis, and seven (35%) had histories of transfusions. Eleven (19%) additional patients were also hepatitis C antibody-positive but were hepatitis B core antibody-positive as well. Twenty-one (36%) patients were both hepatitis C antibody- and hepatitis B core antibody-negative and seven (12%) were hepatitis C antibody-negative but hepatitis B core antibody-positive.
The prevalence of hepatitis C antibody was also determined among three other population groups serving as controls and found to be 14% in 28 HbsAg-positive patients with hepatocellular carcinoma, 44% in 76 patients with cryptogenic cirrhosis and 0.5% in 200 consecutive volunteer blood donors.
We conclude that hepatitis C antibody is prevalent among patients with hepatocellular carcinoma and may therefore be a common causative agent of this disease. A significant number of patients with and without cirrhosis, negative for hepatitis C antibody and hepatitis B core antibody, remain without a discernible cause for this malignancy. Perhaps a second-or third-generation test will detect hepatitis C antibody in some of these patients. (HEPATOLOGY 1990;12:589–591).