Double-blind investigation of the effects of propranolol and placebo on the pressure of esophageal varices in patients with portal hypertension
Article first published online: 5 DEC 2005
Copyright © 1991 American Association for the Study of Liver Diseases
Volume 13, Issue 5, pages 917–922, May 1991
How to Cite
Feu, F., Bordas, J. M., Garcia-Pagán, J. C., Bosch, J. and Rodés, J. (1991), Double-blind investigation of the effects of propranolol and placebo on the pressure of esophageal varices in patients with portal hypertension. Hepatology, 13: 917–922. doi: 10.1002/hep.1840130519
- Issue published online: 5 DEC 2005
- Article first published online: 5 DEC 2005
- Manuscript Accepted: 7 DEC 1990
- Manuscript Received: 16 JUL 1990
- Comissió Interdepartamental de Recerca i Innovació Tecnologia and from the Fondo de Investigaciones Sanitarias de la Seguridad Social. Grant Number: 91/0374
This study was aimed at investigating the effects of propranolol on esophageal variceal pressure in patients with portal hypertension.
Variceal pressure was measured at endoscopy using a miniature pressure-sensitive gauge in 20 patients with portal hypertension. Measurements were obtained under baseline conditions and 20 min after double-blind administration of propranolol (0.15 mg/kg; n = 10) or an identical amount of placebo (normal saline, 0.3 ml/kg; n = 10).
Under baseline conditions, variceal pressure was similar in propranolol and placebo groups (14.1 ± 5 mm Hg vs. 14.9 ± 6.6 mm Hg, respectively; not significant). Placebo had no significant effect on variceal pressure (baseline = 14.9 ± 6.6 mm Hg; placebo = 15.5 ± 6.6 mm Hg; not significant), and values after placebo administration were closely correlated with baseline values (r = 0.98; y = 1.1 + 0.97 x; p < 0.0001). In contrast, propranolol caused a significant decrease in the pressure of esophageal varices (from 14.1 ± 5 mm Hg to 11.3 ± 4.4 mm Hg; p < 0.002). No significant changes in the size of esophageal varices were observed after propranolol or placebo administration.
This study shows (a) the endoscopic pressure-gauge technique has a low variability and may be used to assess acute drug-induced changes in variceal pressure; and (b) propranolol causes significant decreases in variceal pressure in patients with portal hypertension and esophageal varices. (HEPATOLOGY 1991;13:917–922.)