Studies on mechanisms of augmentation of liver regeneration by cyclosporine and FK 506

Authors

  • Antonio Francavilla M.D., Ph.D.,

    Corresponding author
    1. Department of Gastroenterology, University of Bari, Bari 70100, Italy
    • Veterans Administration Hospital, University Drive C, Building 6, Circle Drive, Pittsburgh, PA 15213
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  • Thomas E. Starzl,

    1. The Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
    2. The Department of Pathology, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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  • Michele Barone,

    1. Department of Gastroenterology, University of Bari, Bari 70100, Italy
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  • Qi-Hua Zeng,

    1. The Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
    2. The Department of Pathology, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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  • Kendrick A. Porter,

    1. Department of Pathology, Saint Mary's Hospital and Medical School, London W2, United Kingdom
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  • Adrianni Zeevi,

    1. The Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
    2. The Department of Pathology, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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  • Peter M. Markus,

    1. The Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
    2. The Department of Pathology, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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  • Marcell R. M. van den Brink,

    1. The Department of Neuroscience, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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  • Satoru Todo

    1. The Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
    2. The Department of Pathology, University Health Center of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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Abstract

Evidence could not be found of immune modulation of liver regeneration. The powerful immunosuppressive drug FK 506, which augments the response after partial hepatectomy in normal rats, had the same effect in T cell—deficient nude rats. The cytotoxicity of natural killer cells in treated nude rats was not significantly changed by FK 506 therapy. However, the serum of FK 506—treated nude rats increased hepatocyte proliferation when added to third-party hepatocyte cultures, suggesting that FK 506 had induced a serum growth factor in the nude rats or had suppressed an inhibitory factor. A hypothesis was advanced that FK 506 (and cyclosporine) affects hepatic growth by nonimmunological pathways. (HEPATOLOGY 1991;14:140–143.)

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