Hemodynamic effects of terbutaline, a β2-adrenoceptor agonist, in conscious rats with secondary biliary cirrhosis
Article first published online: 5 DEC 2005
Copyright © 1992 Wiley Subscription Services, Inc.
Volume 15, Issue 3, pages 459–463, March 1992
How to Cite
Poo, J. L., Braillon, A., Hadengue, A., Gaudin, C. and Lebrec, D. (1992), Hemodynamic effects of terbutaline, a β2-adrenoceptor agonist, in conscious rats with secondary biliary cirrhosis. Hepatology, 15: 459–463. doi: 10.1002/hep.1840150318
- Issue published online: 5 DEC 2005
- Article first published online: 5 DEC 2005
- Manuscript Accepted: 10 OCT 1991
- Manuscript Received: 11 JUL 1991
The hemodynamic responses to terbutaline – a selective β2-adrenoceptor agonist – were studied in conscious normal rats and in conscious rats with secondary biliary cirrhosis. Compared with those of normal rats, dose-response curves in cirrhotic rats indicated significantly decreased reactivity in arterial pressure and heart rate. Half-maximal effective dose was not significantly different between the two groups. Terbutaline induced significant, dose-dependent decreases in portal pressure in both normal rats (9.3%) and cirrhotic rats (13.8%). In normal rats, terbutaline administration (32 μg ± min−1 ± kg−1 body wt) increased both cardiac output and portal tributary blood flow, thus mimicking hemodynamic changes in cirrhotic rats. In cirrhotic rats, despite a significant increase in portal tributary blood flow (from 19.9 ± 1.7 ml/min to 22.7 ± 1.5 ml/min), terbutaline decreased portal pressure from 17.4 ± 1.0 mm Hg to 15.0 ± 0.8 mm Hg. This study indicates that increased β2-adrenoceptor stimulation in cirrhotic rats may be involved in hyperdynamic circulation. The association of a decreased portal pressure and increased splanchnic blood flow suggests that β2-adrenoceptor stimulation may modulate hepatic and portal collateral vascular resistance. (Hepatology 1992;15:459–463).