James B. Burgess was supported by a National Research Service Award Institutional Training Grant from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.
Abnormal surface distribution of the human asialoglycoprotein receptor in cirrhosis
Article first published online: 5 DEC 2005
Copyright © 1992 Wiley Subscription Services, Inc.
Volume 15, Issue 4, pages 702–706, April 1992
How to Cite
Burgess, J. B., Baenziger, J. U. and Brown, W. R. (1992), Abnormal surface distribution of the human asialoglycoprotein receptor in cirrhosis. Hepatology, 15: 702–706. doi: 10.1002/hep.1840150425
- Issue published online: 5 DEC 2005
- Article first published online: 5 DEC 2005
- Manuscript Accepted: 20 NOV 1991
- Manuscript Received: 31 JAN 1991
- Department of Veterans Affairs and National Institutes of Health. Grant Number: R37 CA21923
Serum concentrations of asialoglycoproteins are increased in cirrhosis. We hypothesized that this increase results from abnormalities in the asialoglycoprotein receptor, which is located on the sinusoidal and lateral membrane of hepatocytes. Therefore we searched for morphological alterations in the distribution of the asialoglycoprotein receptor in human liver, using a light microscopic immunoperoxidase method in autopsy livers. In 24 of 25 (96%) of patients without liver disease, the asialoglycoprotein receptor was located on the sinusoidal and, less prominently, the lateral surface of hepatocytes but not the canalicular surface. In contrast, in 12 of 18 (67%) patients with cirrhosis of various causes, the receptor also was localized strikingly along the canalicular surface, with a corresponding decrease on the sinusoidal and lateral surfaces. We conclude that an abnormal cell-surface distribution of the asialoglycoprotein receptor commonly occurs in cirrhosis. This abnormality might result in impaired clearance of desialylated glycoproteins from plasma. (Hepatology 1992;15:702–706).