An “ironic” case of mistaken identity?
Article first published online: 5 DEC 2005
Copyright © 1992 American Association for the Study of Liver Diseases
Volume 16, Issue 2, pages 500–501, August 1992
How to Cite
Kowdley, K. V. and Tavill, A. S. (1992), An “ironic” case of mistaken identity?. Hepatology, 16: 500–501. doi: 10.1002/hep.1840160234
- Issue published online: 5 DEC 2005
- Article first published online: 5 DEC 2005
An iron loaded liver from a 40 year old man with occult haemochromatosis was transplanted into a 19 year old woman with acute liver failure secondary to a paracetamol overdose. Increased parenchymal hepatic iron was found in a liver specimen at biopsy under-taken because of mild rejection 30 days after transplantation. After transplantation the patient had two episodes of liver rejection confirmed by biopsy. The hepatic iron concentration fell from 161 μmol/g on day 30 after transplant to 26.5 μmol/g (normal < 40) on day 210. Iron absorption, measured 45 days after transplant, was in the normal range at 12.4%. The rapid fall in hepatic iron and the normal iron absorption study result suggest that the genetic defect of haemochromatosis is not exclusively an intrahepatic defect.