This work was presented in part at the 41st Annual Meeting of the American Association for the Study of Liver Diseases in Chicago, November 3–6, 1990, and published in abstract form (HEPATOLOGY 1990;12:854).
Hemodynamic effects of calibrated stenosis of the superior mesenteric artery in conscious rats with portal vein stenosis†
Article first published online: 5 DEC 2005
Copyright © 1992 American Association for the Study of Liver Diseases
Volume 16, Issue 6, pages 1447–1451, December 1992
How to Cite
Soubrane, O., Braillon, A., Lin, H.-C., Kleber, G. and Lebrec, D. (1992), Hemodynamic effects of calibrated stenosis of the superior mesenteric artery in conscious rats with portal vein stenosis. Hepatology, 16: 1447–1451. doi: 10.1002/hep.1840160622
- Issue published online: 5 DEC 2005
- Article first published online: 5 DEC 2005
- Manuscript Accepted: 20 JUL 1992
- Manuscript Received: 29 JAN 1992
- Fondation pour la Recherche Médicale
- French government
- Veterans General Hospital-Taipei
- National Science Council, Taiwan, R.O.C.
Because superior mesenteric arterial blood flow is increased in portal hypertension and plays a role in elevated portal pressure, mechanical reduction of artery diameter should induce decreases in portal pressure and superior mesenteric arterial blood flow. In this study, calibrated superior mesenteric artery stenosis (induced with a 22-gauge needle) was performed in rats simultaneously with portal vein stenosis or 2 wk after creation of portal vein stenosis. Hemodynamic studies were performed 3 wk after induction of portal vein stenosis in conscious, unrestrained rats. At that time, neither weight loss nor digestive tract alterations were observed in rats with arterial stenosis. In neither group of rats with arterial stenosis was portal tributary blood flow significantly different from that of normal rats; nor was it significantly lower than in rats with portal vein stenosis without arterial stenosis. In both groups of rats with arterial stenosis, portal pressure was significantly lower (12.1 ± 1.6 mm Hg and 12.5 ± 1.8 mm Hg, respectively) than in rats subjected to portal vein stenosis (15.4 ± 1.5 mm Hg) but significantly higher than in controls (7.2 ± 1.0 mm Hg). In rats with arterial stenosis, cardiac index was also significantly lower than that in rats with portal vein stenosis but higher than that in controls. In conclusion, this study shows that both early and late superior mesenteric artery stenosis significantly reduce the degree of portal hypertension and the hyperkinetic state of rats with extrahepatic portal hypertension. Thus we can speculate that superior mesenteric artery stenosis might provide a new therapeutic approach for portal hypertension.