Brachial and femoral artery blood flow in cirrhosis: Relationship to kidney dysfunction

Authors

  • Albert Maroto,

    1. Liver Unit, Ultrasonography Unit and Hormonal Laboratory. Hospital Clínic i Provincial, University of Barcelona, 08036 Barcelona, Spain
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  • Pere Ginés,

    1. Liver Unit, Ultrasonography Unit and Hormonal Laboratory. Hospital Clínic i Provincial, University of Barcelona, 08036 Barcelona, Spain
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  • Vicente Arroyo M.D.,

    Corresponding author
    1. Liver Unit, Ultrasonography Unit and Hormonal Laboratory. Hospital Clínic i Provincial, University of Barcelona, 08036 Barcelona, Spain
    • Liver Unit, Hospital Clínic i Provincial, Villarroel 170, 08036-Barcelona, Spain
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  • Angels Ginés,

    1. Liver Unit, Ultrasonography Unit and Hormonal Laboratory. Hospital Clínic i Provincial, University of Barcelona, 08036 Barcelona, Spain
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  • Joan Saló,

    1. Liver Unit, Ultrasonography Unit and Hormonal Laboratory. Hospital Clínic i Provincial, University of Barcelona, 08036 Barcelona, Spain
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  • Joan Clária,

    1. Liver Unit, Ultrasonography Unit and Hormonal Laboratory. Hospital Clínic i Provincial, University of Barcelona, 08036 Barcelona, Spain
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  • Wladimiro Jiménez,

    1. Liver Unit, Ultrasonography Unit and Hormonal Laboratory. Hospital Clínic i Provincial, University of Barcelona, 08036 Barcelona, Spain
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  • Concepció Bru,

    1. Liver Unit, Ultrasonography Unit and Hormonal Laboratory. Hospital Clínic i Provincial, University of Barcelona, 08036 Barcelona, Spain
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  • Francisca Rivera,

    1. Liver Unit, Ultrasonography Unit and Hormonal Laboratory. Hospital Clínic i Provincial, University of Barcelona, 08036 Barcelona, Spain
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  • Joan Rodés

    1. Liver Unit, Ultrasonography Unit and Hormonal Laboratory. Hospital Clínic i Provincial, University of Barcelona, 08036 Barcelona, Spain
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Abstract

Brachial artery and common femoral artery blood flows and cardiac output were measured with duplex-Doppler ultrasonography in 12 normal subjects, 12 patients with compensated cirrhosis and 35 patients with cirrhosis and ascites (8 with functional kidney failure). The aim of this study was to investigate whether arteriolar vasodilation in these vascular territories contributes to hyperdynamic circulation in cirrhosis. Cardiac output was significantly increased and systemic vascular resistance significantly reduced in the three groups of cirrhotic patients. We found no significant differences between normal subjects and compensated cirrhotic patients in brachial artery (55 ± 7 vs. 57 ± 7 ml/min) and femoral artery (353 ± 20 vs. 310 ± 25 ml/min) blood flow. Nonazotemic cirrhotic patients with ascites showed significantly lower (p < 0.05) brachial artery blood flow (40 ± 3 ml/min) than healthy subjects and compensated patients. Femoral artery blood flow (327 ± 25 ml/min), however, was not significantly different. Brachial artery (25 ± 3 ml/min) and femoral artery (213 ± 22 ml/min) blood flows were markedly reduced in the patients with kidney failure (p < 0.05 with respect to the other three groups). Glomerular filtration rate correlated directly with brachial (r = 0.74, p = 0.0001) and femoral (r = 0.52, p = 0.03) artery blood flow in the cirrhotic patients. These results indicate that the arteriolar vasodilation causing hyperdynamic circulation in cirrhosis does not take place in the brachial and femoral vascular territories. (HEPATOLOGY 1993;17:788–793.)

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