Presented in part at the American Gastroenterological Association Annual Meeting, San Francisco, 1992.
Effects of bile duct ligation on calcium excretion in the rat†
Article first published online: 5 DEC 2005
Copyright © 1994 American Association for the Study of Liver Diseases
Volume 19, Issue 2, pages 457–463, February 1994
How to Cite
Vakil, N., Sharma, A. and Yagil, Y. (1994), Effects of bile duct ligation on calcium excretion in the rat. Hepatology, 19: 457–463. doi: 10.1002/hep.1840190226
- Issue published online: 5 DEC 2005
- Article first published online: 5 DEC 2005
- Manuscript Accepted: 7 SEP 1993
- Manuscript Received: 31 MAR 1993
- United States Public Health Service. Grant Number: PHS S7RR05403-28
In an earlier study we showed that bile duct–ligated rats were highly susceptible to gentamicin nephrotoxicity and that oral calcium administration had a pronounced protective effect. The mechanism by which this occurs is unclear. Because cations compete with gentamicin for tubule binding sites, it has been suggested that the increased susceptibility of the kidney to gentamicin after bile duct ligation might result from decreased cation excretion. The aim of this study was to determine the effect of bile duct ligation on calcium excretion in relation to overall renal function. Male Sprague-Dawley rats underwent bile duct ligation and division. Pair-fed sham-operated rats served as controls. Metabolic and clearance studies were carried out at 3, 5, 7, 14 and 21 days after surgery. Urine output was higher in bile duct–ligated rats, and they excreted more calcium at 3, 5, 7 and 14 days, while excreting less sodium than controls. We conclude that after bile duct ligation, there is increased calcium excretion, which is independent of the abnormality in sodium excretion. Enhanced nephrotoxicity with aminoglycosides in the bile duct–ligated rat model cannot be explained by decreased calcium excretion. (Hepatology 1994;19:457–463).