DNA damage and donor livers: Disease unbidden?
Article first published online: 5 DEC 2005
Copyright © 1995 American Association for the Study of Liver Diseases
Volume 21, Issue 6, pages 1743–1745, June 1995
How to Cite
Schwarz, K. (1995), DNA damage and donor livers: Disease unbidden?. Hepatology, 21: 1743–1745. doi: 10.1002/hep.1840210637
- Issue published online: 5 DEC 2005
- Article first published online: 5 DEC 2005
Endogenous DNA adducts may contribute to the etiology of human genetic disease and cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde. A sensitive mass spectrometric method permitted detection and quantitation of the major malondialdehyde-DNA adduct, a pyrimidopurinone derived from deoxyguanosine. DNA from disease-free human liver was found to contain 5400 adducts per cell, a frequency comparable to that of adducts formed by exogenous carcinogens. Reprinted with permission from Science 1994;265:1580–1581.