• 1
    Hieter P, Boguski M. Functional genomics: it's all how you read it. Science 1997; 278: 601602.
  • 2
    Velculescu VE, Zliang L, Vogelstein B, Kinzler KW. Serial analysis of gene expression. Science 1995; 270: 484487.
  • 3
    Byers RJ, Hoyland JA, Dixon J, Freemont AJ. Subtractive hybridizationgenetic takeaways and the search for meaning. Int J Exp Pathol 2000; 81: 391404.
  • 4
    Ali M, Markharn AF, Isaacs ID. Application of differential display to immunological research. J Imrnunol Methods 2001; 250: 2943.
  • 5
    Granjeaud S, Bertucci F, Jordan BR. Expression profiling: DNA arrays in many guises. Bioessays 1999; 21: 781790.
  • 6
    Green CD, Sirnons JF, Taillon BE, Lewin DA. Open systems: panoramic views of gene expression. J Immunol Methods 2001; 250: 6779.
  • 7
    Epstein CB. Butow RA. Microarray technology-enhanced versatility, persistent challenge. Curr Opin Biotechnol 2000; 11: 3641.
  • 8
    Khan J, Bittner ML, Chen Y, Melrzer PS, Trent JM. DNA microarray technology: the anticipated impact on the srudy of human disease. Biochim Biophys Acta 1999; 25: M1728.
  • 9
    Schena M, Heller RA, Theriault TP, Konrad K, Lachenmeier E, Davis KW. Microarrays: biotechnology's discovery platform for functional genomics. Trends Biotechnol 1998; 16: 301306.
  • 10
    Ranisay G. DNA chips: state-of-the art. Nature Biotechnol 1998; 16: 4044.
  • 11
    Bertucci F, Bernard K, Loriod B, Chang YC, Granjeaud S, Birnbaum D. Nguyen C, et al. Sensitivity issues in DNA array-based expression measurements and performance of nylon microarrays for small samples. Hum Mol Genet 1999; 8: 17151722.
  • 12
    Cox JM. Applications ofnylon membrane arrays to gene expression analysis. J Ininiunol Methods 2001; 250: 313.
  • 13
    Yue H, Eastman PS, Wang BB, Minor J, Doctolero MH, Nuttail RL, Stack R. et al. An evaluation of the performance of cDNA microarrays for detecting changes in global mRNA expression. Nucleic Acids Res 2001; 29: E4141.
  • 14
    Lee Ml, Kuo FC, Whitmore GA, Sklar J. Importance of replication in microarray gene expresiion studies: staristical methods and evidence from repetitive cDNA hybridizations. Proc Natl Acad Sci USA 2000; 97: 98349839.
  • 15
    Lipshum RJ. Applications of high-density oligonucleotide arrays. Novartis Foundation Symposium 2000; 229: 8490; discussion 90-83.
  • 16
    Lipshurz RJ, Fodor SP, Gingeras TR, Lockhart DJ. High density synthetic oligonucleotide arrays. Nat Genet 1999; 21: 2024.
  • 17
    Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chec MS, Mittniann M. et al. Expression monitoring by hybridization to higlidensity oligonuclcoride arrays. Nature Biotechnol 1996; 14: 16751680.
  • 18
    McGall G, Labadie J, Brock P, Wallraff G, Nguyen T. Hinsberg W. Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists. proc Natl Acad Sci USA 1996; 93: 1355513560.
  • 19
    Chee M, Yang R, Hubbell E. Berno A, Huang XC. Srcrn D, Winkler J, et al. Accessing genetic information with high-density DNA arrays. Science 1996; 274: 610614.
  • 20
    Pease AC. Solas D, Sullivan EJ, Cronin MT, Holmes CP, Fodor SP. Light-generated oligonucleotide arrays for rapid DNA sequence analysis. Proc Natl Acad Sci USA 1994; 91: 50225026.
  • 21
    Knight J. When the chips are down. Nature 2001; 410: 860861.
  • 22
    Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JCF, Trent JM, et al. The transcriptional program in the response ofhuman fibroblasts to serum. Science 1999; 283: 8387.
  • 23
    Teague TK, Hildeman D, Kedl RM, Mitchell T, Rees W, Schaefer BC, Bender J, et al. Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc Nacl Acad Sci USA 1999; 96: 1269112696.
  • 24
    Scott PA, Smith K, Bicknel R, Harris AL. A reliable external control for ribonuclease protection assays. Nucleic Acids Res 1997; 25: 13051306.
  • 25
    Mills JC, Gordon JI. A new approach for filtering noise from high-density oligonucleotide microarray datasets. Nucleic Acids Res 2001; 29: E7272.
  • 26
    Kane MD, Jatkoe TA, Stumpf CR, Lu J, Thomas JD, Madore SJ. Assessment of rhe sensitivity and specificity of oligonucleotide (50mer) microarrays. Nucleic Acids Res 2000; 28: 45524557.
  • 27
    Coller HA, Grandori C, Tamayo P. Colbert T, Lander ES, Eisenman RN, Golub TR. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci USA 2000; 97: 32603265.
  • 28
    Eberwine J, Yeh H, Miyashiro K, Cao Y, Nair S, Finnell R, Zettel M, et al. Analysis of gene expression in single live neurons. Prof Natl Acad Sci USA 1992; 89: 30103014.
  • 29
    Dent GW, O'Dell DM, Eberwine JH. Gene expression profiling in the amygdala: An approach to examine the molecular substrates of mammalian behavior. Physiol Behav 2001; 73: 841847.
  • 30
    Eberwine J. Amplification of mRNA populations using aRNA generated from immobilized oligo(dT)-T7 primed cDNA. Biotechniques 1996; 20: 584591.
  • 31
    Brady G, Iscove NN. Construction of cDNA libraries from single cells. Meth Enzymol 1993; 225: 611623.
  • 32
    Recker B, Vogt T, Landthaler M, Stolz W. Detection of differentially regulated genes in keratinocytes by cDNA array hybridization: Hsp27 and other novel players in response to artificial ultraviolet radiation. J Invest Dermatol 2001; 116: 983988.
  • 33
    Vernon SD, Unger ER, Rajeevan M, Dimulescu IM, Nisenhaum R, Campbell CE. Reproducibility of alternative prohe synthesis approaches for gene expression profiling with arrays. J Mol Diagnostics 2000; 2: 124127.
  • 34
    Herder M. Use of SMART-generated cDNA for differential gene expression studies. J Mol Med 2000; 78:B23.
  • 35
    Spirin KS, Ljubimov AV, Castellon R, Wiedoeft O, Marano M, Sheppard D, Kenney MC, et al. Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA. Invest Ophthalmol Vis Sci 1999; 40: 31083115.
  • 36
    Seth D, Gorrell MD, McGuinness PH, Leo MA, Lieber CS, McCaughan GW, Haber PS,. SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies ofalcoholic liver disease in primates. J Biochem Biophys Methods (in press).
  • 37
    Chen Y, Dougherty ER, Birtner M. Ratio-based decision and the quantitative analysis of cDNA microarray analysis. J Biomed Optics 1997; 2: 364374.
  • 38
    Wu TD. Analysing gene expression data from DNA microarrays to identify candidate genes. J Pathol 2001; 195: 5365.
  • 39
    Baggerly KA, Coombes KR, Hess KR, Stivers DN, Abruzzo LV, Zhang W. Identifying differentially expressed genes in cDNA microarray experiments. J Comput Biol 2001; 8: 639659.
  • 40
    Kim S, Dougherty ER, Bictner ML, Chen Y, Sivakumar K, Meltzer P, Trent JM. General nonlinear framework for the analysis of gene interaction via multivariate expression arrays. J Biomed Optics 2000; 5: 411424.
  • 41
    Kim S, Dougherty ER, Chen Y, Sivakumar K, Meltzer P, Trent JM, Bittner M. Multivariate measurement of gene expression relationships. Genomics 2000; 67: 201209.
  • 42
    Liang CP, Tall AR. Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in obtob mouse liver. J Biol Chein 2001; 276: 4906649076.
  • 43
    Raychaudhuri S, Sutphin PD, Chang JT, Altman RB. Basic microarray analysis: grouping and feature reduction. Trends Biotechnol 2001; 19: 189193.
  • 44
    McLachlan GJ. Cluster analysis and related techniques in medical research. Stat Methods Med Res 1992; 1: 2748.
  • 45
    Sherlock G. Analysis of large-scale gene expression data. Curr Opin Immunol 2000; 12: 201205.
  • 46
    Quackenbush J. Computational analysis of microarray data. Nat Rev Genet 2001; 2: 418427.
  • 47
    Brown MP, Grundy WN, Lin D, Cristianini N, Sugnet CW, Furey TS, Ares M, et al. Knowledge-based analysis of microarray gene expression data by using support vector machines. Proc Natl Acad Sci USA 2000; 97: 262267.
  • 48
    Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, et al. The sequence ofthe human genome. Science 2001; 291: 13041351.
  • 49
    Velculescu VE, Madden SL, Zhang L, Lash AE, Yu J, Rago C, Lal A, et al. Analysis of human transcriptomes. Nat Genet 1999; 23: 387388.
  • 50
    Liotta L, Petricoin E. Molecular profiling of human cancer. Nat Rev Genet 2000; 1: 4856.
  • 51
    Ross DT, Scherf U, Eisen MB, Perou CM, Rees C, Spellman P, Iyer V, et al. Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet 2000; 24: 227235.
  • 52
    Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999; 286: 531537.
  • 53
    Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503511.
  • 54
    Selaru FM, Xu Y, Yin J, Zou T, Liu TC, Mori Y, Abraham JM, et al. Artificial neural networks distinguish among subtypes of neoplastic colorectal lesions. Gastroenterology 2002; 122: 606613.
  • 55
    Shackel NA, McGuinness PH, Abbort CA, Gorrell MD, McCaughan GW. Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression. Gut 2001; 49: 565576.
  • 56
    Shackel NA, McGuinness PH, Abhott CA, Gorrell MD, McCaughan GW. Insights into the pathobiology of hepatitis C virus associated cirrhosis: analysis of intraheparic differential gene expression. Am J Pathol 2002; 160: 641654.
  • 57
    Yin JL. Shackel NA, Zekry A, McGuinness PH, Richards C, Van der Putten K, McCaughan G, et al. Real-time reverse trasncriprase-polyrnerase chain reaction (RT-PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green I. Immunol Cell Biol 2001: 79: 213221.
    Direct Link:
  • 58
    Curran S, McKay JA, McLeod HL, Murray GI. Laser capture microscopy. Mol Pathol 2000; 53: 6468.
  • 59
    Simone NL, Bonner RF, Gillespie JW, Emmert-Buck MR, Liotta LA. Laser-capture microdissection: opening rhe microscopic frontier to molecular analysis. Trends Genet 1998; 14: 272276.
  • 60
    Gillett CE, Springall RJ. Barnes DM, Hanby AM. Multiple tissue core arrays in histopathology research: a validation study. J Pathol 2000; 192: 549553.
  • 61
    Hoos A, Urist MJ. Stojadinovic A, Mastorides S, Dudas ME, Leung DH. Kuo D, et al. validation of tissue microarrays for immunohistochemical profiling of cancer specimens using the example of human fibroblastic tumors. Am J Pathol 2001; 158: 12451251.
  • 62
    Bigger CB. Brasky KM, Lanford RE. DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection. J Virol 2001; 75: 70597066.
  • 63
    Li W, Liang X, Leu JI, Kovalovich K, Ciliberto G, Taub R. Global changes in interleukin-6-dependent gene expression patterns in mouse livers after parrial hepatectomy. HEPATOLOGY 2001; 33: 13771386.
  • 64
    Eisen MB, Spellman PT, Brown PO, Botstcin D. Cluster analysis: and display of genome-wide expression patterns. Proc Natl Acad Sci USA 1998; 95: 1486314868.
  • 65
    Honda M, Kaneko S. Kawai H, Yukihiro S. Kobayashi K. Differential genc cxprcssion between chronic hepatitis B and C hepatic lesions. Gastroenterology 2001; 120: 955966.
  • 66
    McCaughan GW. Shackel NA. Gorrell MD. Discussion on differential gene expression btrween chronic hepatitis B and C hepatic lesion. Gastroenterology 2001; 121: 12631264.
  • 67
    Yano N, Habib NA, Faddeii KJ. Yamashita H, Mitry R, Jauregui H, Kane A, et al. Profiling the adult human liver transcriptome: analysis by cDNA array hybridization. J Hepatol 2001; 55: 178186.
  • 68
    Hoffniann KF, Carty TC, Segal DH. Chiaramonte M, Hesse M. Davis EM, Cheever AW, et al. Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions. FASEB J 2001: 15: 25452547.
  • 69
    Bulera SJ. Eddy SM. Ferguson E. Latkoe TA, Reindel JF. Bleavins MR, De LA Lglesia FA. RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays. HFPATOLOGY 2001; 33: 12391258.
  • 70
    Cao SX, Dhahbi JM, Mote PL. Spindler SR. Genoniic profiling ofshortand long-term caloric restricrion effects in the liver of aging mice. Proc Natl Acad Sci USA 2001; 98: 1063010635.
  • 71
    Kelley-Loughnane N, Sabla CE, Ley-Ebert C, Aronow BJ, Bezerra JA. Independent and overlapping transcriptional activation during livrr development and regeneration in micc. HEPATOLOGY 2002: 35: 525534.
  • 72
    Pritchard CC, Hsu L. Delrow J. Nelson PS. Project normal: defining normal variance in niouse gene expression. Proc Natl Acad Sci USA 2001; 98: 1326613271.
  • 73
    Baker TK, Carfagna MA. Gao H, Dow ER, Li Q, Searfoss GH, Ryan TP. Tempnral grne expression analysis of monolayer culturcd rat hepatocytes. Chem Res Toxicol 2001; 14: 12181231.
  • 74
    Kita Y, Shiozawd M. Jin W, Majewski RR. Besharsc JC, Greene AS, Jacob HJ. Implicarions of circadian gene expression in kidney, liver and thc effects of faxing on pharmacogenoinic studies. Pharmacogenecics 2002; 12: 5565.
  • 75
    Phan J, Pesaran T, Davis RC, Reue K. The Diet1 locus confers protection against hypercholesrerolcmia through enhanced bile acid metabolism. J Biol Cheni 2002: 277: 469477.
  • 76
    Tobe K, Suzuki R, Aoyama M. Yamauchi T, Kanion J, Kubota N. Terauchi Y, et al. Increased expression of rhc sterol regulatory elementbinding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver. J Biol Cheni 2001; 276: 3833738340.
  • 77
    Krrsten S, Mandard S, Escher P, Gonzalcz FJ, Tafuri S, Desvergne B. Wahli W. The peroxisoine proliferator-activated receptor alpha regulates amino acid metabolism. FASEB J 2001; 15: 19711978.
  • 78
    Huang CS, Yang SM, Hong MY, Yang PC, Liu YC. Differenrial gene expression of livers from ApoE deficient mice. Life Sci 2000; 68: 1928.
  • 79
    Callow MJ, Dudoit S, Gong EL, Speed TP. Ruhin EM. Microarray expression profiling identifies genes with altered expression in HDL-dcficienr mice. Genome Res 2000: 10: 20222029.
  • 80
    Gregoire FM, Zhang Q, Smith SJ, Tong C, Ross D, Lopez H, West DB. Diet-induced obeslty and hepatic gene expression alteration in C57BI/6J and ICAM-1-deficient mice. Am J Physiol Endocrinol Metab 2002; 282: F703713.
  • 81
    Fischer A, Pallauf J, Gohil K, Wtber SU, Packer L, Rimbach G. Effect of selenium and vitamin E deficiency on diffcrcntial gene expression in rat liver. Biochcm Biophys Res Commun 2001; 285: 470475.
  • 82
    Lichtlen P, Wang Y, Belser T, Georgicv O. Certa U, Sack R, Schaffner W. Target gene search for the metal-responsive transcription factor MTF-1. Nucleic Acids Kes 2001: 29: 15141523.
  • 83
    Feng X, Jimg Y. Melrzer P, Ycn PM. Transgenic targeting of a dominant negative corepressor to liver blocks basal repression by thyroid hormone receptor and incrrases cell proliferation. J Biol Chem 2001: 276: 1506615072.
  • 84
    Feng X. Jiang Y, Meltzer P, Yen PM. Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray. Mol Endocrinol 2000; 14: 947955.
  • 85
    Radaeva S, Jaruga B, Hong F, Kim WH, Fan S, Cai H, Strom S, et al. Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes. Gastroenterology 2002; 122: 10201034.
  • 86
    Schnabl B, Choi YH, Olsen JC, Hagedorn CH, Brenner DA. Immortal activated human hepatic stellare cells generated by ectopic relomerase expression. Lab Invest 2002; 82: 323333.
  • 87
    Wang X. Quail E. Hung NJ, Tan Y, Ye H, Costa RH. Increased levels of forkhead box M 1 B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver. Proc Natl Acad Sci USA 2001; 98: 1146811473.
  • 88
    Lu SC, Alvarez L, Huang ZZ. Chen L, An W, Corrales FJ, Avila MA, et al. Methionine adenosyltransferase IA knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci USA 2001; 98: 55605565.
  • 89
    Thompson BJ, Shang CA, Waters MJ. Identification ofgenes induced by growth hormorie in rat liver using cDNA arrays. Endocrinology 2000; 141: 43214324.
  • 90
    Liu J. Saavedra JE. Lu T, Song JG, Clark J, Waalkes MP, Keefer LK. 0(2)-Vinyl 1-(pyrrolidin-1-yl)diazen-l-ium-l,2-diolate protection against D-galactosaminelendotoxin-induced hepatotoxicity in mice: gcnomic analysis using microarrays. J Pharmacol Exp Ther 2002; 300: 1825.
  • 91
    Reilly TP, Bourdi M, Brady JN, Pisc Masison CA, Radonovich MF, George JW, Pohl LR. Expression profiling of acetaminophen liver toxicity in mice usins microarray technology. Biochem Biophys Res Commun 2001; 282: 321328.
  • 92
    Yamazaki K, Kuromitsu J, Tanaka I. Microarray analysis of gene expres sion changes in niousc liver induced by peroxisome proliferator-activated receptor alpha agonists. Biochem Biophys Res Commun 2002; 290: 11141122.
  • 93
    Ueda A, Hamadeh HK, Webb HK, Yamamoto Y, Sueyoshi T, Afshari CA, Lehmann JM, et al. Diverse roles of rhe nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol Pharniacol 2002; 61: 16.
  • 94
    Waring JF, Jolly RA, Ciurlionis R, Lum PY, Praestgaard JT, Morfitt DC, Buratto B, et al. Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles. Toxicol Appl Pharmacol 2001; 175: 2842.
  • 95
    Gerhold D, Lu M, Xu J, Austin C, Caskey CT, Rushmore T. Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays. Physiol Genomics 2001; 5: 161170.
  • 96
    Waring JF, Ciurlionis R, Jolly RA, Heindcl M, Ulrich RG. Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity. Toxicol Lett 2001; 120: 359368.
  • 97
    Chen H. Liu J, Merrick BA. Waalkes MP. Genetic events associated with arsenic-induced malignanr transformation: applications of cDNA microarray technology. Mol Carcinog 2001; 30: 7387.
  • 98
    Bartosiewicz M, Penn S, Buckpitt A. Applications of gene arrays in environmcntal toxicology: fingerprints ofgene regulation associated with cadmium chloride, benzo(a)pyrene. and trichloroethylene. Environ Health Perspect 2001; 109: 7174.
  • 99
    Lu T, Liu J, LcCluyse EL, Zhou YS, Cheng ML, Waalkcs MP. Application of cDNA microarray to the srudy of arsenic-induced liver diseases in the popularion of Guizhou, China. Toxicol Sci 2001; 59: 185192.
  • 100
    Holden PK, Jarnes NH, Brooks AN, Roberts RA, Kimber I, Pennie WD. Identification of a possible association between carbon tetrachloridc-induced hepatotoxicity and interleukin-8 expression. J Biochcm Mu1 Toxicol 2000; 14: 283290.
  • 101
    Bartosiewicz M, Trounstine M, Barker D, Johnston R, Buckpirt A. Developmcnt of a toxicological gene array and quantirative assessment of this technology. Arch Biocheni Biophys 2000; 376: 6673.
  • 102
    Scandurro AB, Weldon CW, Figueroa YG, Alam J, Beckman BS. Gene microarray analysis reveals a novel hypoxia signal transduction pathway in human hepatocellular carcinoma cells. Int J Oncol 2001; 19: 129135.
  • 103
    Huang R, Wu T, Xu L, Liu A, Ji Y, Hu G. Upstream binding factor up-regulated in hepatocellular carcinoma is related to the survival and cisplatin-sensitivity of cancer cells. FASEB J 2002; 16: 293301.
  • 104
    Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, et al. Insighr into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma wirh those of corresponding noncancerous liver. Proc Natl Acad Sci USA 2001; 98: 1508915094.
  • 105
    Yanagawa R, Furukawa Y, Tsunoda T, Kitahara O, Kameyama M, Murara K, Ishikawa O, et al. Genome-wide screening of genes showing altered expression in liver metastases of human colorectal cancers by cDNA microarray. Neoplasia 2001; 3: 395401.
  • 106
    Takeo S, Arai H, Kusano N, Harada T, Furuya T, Kawauchi S, Oga A, et al. Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: comparison with comparative genomic hybridization analysis. Cancer Genet Cytogenet 2001; 130: 127132.
  • 107
    Xiao SY, Wang HL. Harr J, Fleming D, Beard MR. cDNA arrays and immunohistochemistry identification of CD10/CALLA expression in hepatocellular carcinoma. Am J Pathol 2001; 159: 14151421.
  • 108
    Tackels-Horne D, Goodman MD, Williams AJ, Wilson DJ, Eskandari T, Vogt LM, Boland JF, et al. Identification of differentially expressed genes in hepatocellular carcinoma and metastatic liver tumors by oligonucleotide expression profiling. Cancer 2001; 92: 395405.
  • 109
    Xu L, Hui L, Wang S, Gong J, Jin Y, Wang Y, Ji Y, et al. Expression profiling suggested a regulatory role ofliver-enriched transcription factors in human hepatocellular carcinoma. Cancer Res 2001; 61: 31763181.
  • 110
    Shirota Y, Kaneko S, Honda M, Kawai HF, Kobayashi K. Identification of differentially expressed genes in hepatocellular carcinoma with cDNA microarrays. HEPATOLOGY 2001; 33: 832840.
  • 111
    Okabe H. Satoh S, Kato T, Kitahara O, Yanagawa R, Yamaoka Y, Tsunoda T, et al. Genome-wide analysis of gene expression in human heparocellular carcinomas using cDNA microarray: identification ofgenes involved in viral carcinogenesis and tumor progression. Cancer Res 2001; 61: 21292137.
  • 112
    Kawai HF, Kaneko S, Honda M, Shirota Y, Kobayashi K. a-Fetoproteinproducing hepatoma cell lines share common expression profiles of genes in various categories demonstrated by cDNA microarray analysis. HEPATOLOGY 2001; 33: 676691.
  • 113
    Lau WY, Lai PB, Leung MF, Leung BC, Wong N, Chen G, Leung TW, et al. Differential gene expression of hepatocellular carcinoma using cDNA microarray analysis. Oncol Res 2000; 12: 5969.
  • 114
    Wu CG, Salvay DM, Forgues M, Valerie K, Farnsworth J, Markin RS, Wang XW. Distinctive gene expression profiles associated with hepatitis B virus x protein. Oncogene 2001; 20: 36743682.
  • 115
    Han J, Yoo HY, Choi BH, Rho HM. Selective transcriptional regulations in the human liver cell by hepatitis B viral X protein. Biochem Biophys Res Commun 2000; 272: 525530.
  • 116
    Huang Y, Uchiyama Y, Fujimura T, Kanamori H, Doi T, Takamizawa A, Hamakubo T, et al. A human hepatoma cell line expressing hepatitis C virus nonstructural proteins tightly regulated by tetracycline. Biochem Biophys Res Commun 2001; 281: 732740.
  • 117
    Haberberger TC, Kupfer K, Murphy JE. Profiling of genes which are differentially expressed in mouse liver in response to adenoviral vectors and delivered genes. Gene Ther 2000; 7: 903909.
  • 118
    Reilly TP, Brady JN, Marchick MR, Bourdi M, George JW, Radonovich MF, Pise-Masison CA, et al. A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. Chem Res Toxicol 2001; 14: 16201628.
  • 119
    Sone H, Shimano H, Sakakura Y, Inoue N, Amerniya-Kudo M, Yahagi N, Osawa M, et al. Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status. Am J Physiol Endocrinol Metab 2002; 282: E222230.
  • 120
    Tamayo P, Slonim D, Mesirov J, Zhu Q, Kitareewan S, Dmitrovsky E, Lander ES, et al. Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci USA 1999; 96: 29072912.