Editorial
You have full text access to this OnlineOpen article
A la carte or menu fixe: Improving pharmacologic therapy of portal hypertension
Article first published online: 7 MAR 2007
DOI: 10.1002/hep.1840360606
Copyright © 2002 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Bosch, J. (2002), A la carte or menu fixe: Improving pharmacologic therapy of portal hypertension. Hepatology, 36: 1330–1332. doi: 10.1002/hep.1840360606
Publication History
- Issue published online: 7 MAR 2007
- Article first published online: 7 MAR 2007
Funded by
- Fondo de Investigación Sanitaria. Grant Number: PI 020739
Reference
- 1, , , Propranolol—a medical treatment for portal hypertension? Lancet 1980; 2 (8187): 180–182.
- 2, , The treatment of portal hypertension: a meta-analytic review. Hepatology 1995; 22: 332–354.Direct Link:
- 3, , Pharmacological treatment of portal hypertension: an evidence-based approach. Semin Liver Dis 1999; 19: 475–505.
- 4, , , , , , et al. Hemodynamic evaluation of patients with intrahepatic portal hypertension. Relationship between bleeding varices and the portohepatic gradient. Gastroenterology 1975; 69: 1297–1300.
- 5, , , , , Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology 1985; 5: 419–424.Direct Link:
- 6, , , , , , et al. Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage. Gastroenterology 1990; 99: 1401–1407.
- 7, , , , , , et al. Prognostic value of hepatic venous pressure gradient measurements in alcoholic cirrhosis: a 10-year prospective study. Gastroenterology 1996; 111: 701–709.
- 8, , , , , , et al. The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2000; 32: 930–934.Direct Link:
- 9, , , , , , et al. Relation between portal pressure response to pharmacotherapy and risk of recurrent variceal haemorrhage in patients with cirrhosis. Lancet 1995; 346: 1056–1059.
- 10, , , , , , et al. Predictive value of the variceal pressure response to continued pharmacological therapy in patients with cirrhosis and portal hypertension. Hepatology 2000; 31: 1061–1067.Direct Link:
- 11, , , , , , et al. “A la carte” treatment of portal hypertension: adapting medical therapy to hemodynamic response for the prevention of bleeding. Hepatology 2002; 36: 1361–1366.
- 12, , , , , , et al. Nadolol plus isosorbide mononitrate compared with sclerotherapy for the prevention of variceal rebleeding. N Engl J Med 1996; 334: 1624–1629.
- 13, , , , , , et al. Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding. N Engl J Med 2001; 345: 647–655.
- 14, Endoscopic variceal banding vs. pharmacological therapy for the prevention of recurrent variceal hemorrhage: what makes the difference? Gastroenterology 2002; 123: 1388–1391.
- 15, , , Clearance by the liver in cirrhosis. II. Characterization of propranolol uptake with the multipleindicator dilution technique. Hepatology 1993; 18: 823–831.Direct Link:
- 16, , , , , , et al. The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med 2001; 345: 1030–1035.
- 17, , , , , , et al. Short-term effects of propranolol on portal venous pressure. Hepatology 1986; 6: 101–106.Direct Link:
- 18, , , , , , et al. The portal pressure response to beta-blockade is greater in cirrhotic patients without varices than in those with varices. Gastroenterology 1997; 112: 2012–2016.
- 19, , , , , , et al. Effects of propranolol on azygos venous blood flow and hepatic and systemic hemodynamics in cirrhosis. Hepatology 1984; 4: 1200–1205.Direct Link:
- 20, , , , , The HVPG-response to pharmacological treatment of portal hypertension predicts prognosis and the risk of developing complications of cirrhosis. J Hepatol 2002; 36 (Suppl 1): 15A.
- 21, , , , Hemodynamic evaluation of the patient with portal hypertension. Semin Liver Dis 1986; 6: 309–317.
- 22The hepatic venous pressure gradient: has the time arrived for its application in clinical practice? Hepatology 1996; 24: 739–741.Direct Link:
- 23, , , , , , et al. “Diagnosis of Portal Hypertension. How and when?” In: de FranchisR, ed. Portal Hypertension III. Proceedings of the Third Baveno International Consensus Workshop on Definitions, Methodology and therapeutic Strategies. Oxford: Blackwell Science, 2001: 36–63.
- 24, , Portal hypertension. In: Schiff E, Maddrey W, Sorrell M, eds. Schiff s Diseases of The Liver. 2002 (in press).
- 25, , , , , et al. Portal hypertension and variceal bleeding: an AASLD single topic symposium. Hepatology 1998; 28: 868–880.Direct Link:
- 26, , , Influence of pharmacological agents on portal hemodynamics: basis for its use in the treatment of portal hypertension. Semin Liver Dis 1999; 19: 427–438.
- 27, , Current management of portal hypertension. J Hepatol 2002 (in press).

1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
1527-3350/asset/cover.gif?v=1&s=3cd983af6575c8dbfd6b47a63ffa95415ace15f8)