• 1
    Regel G, Grotz M, Weltner T, Sturm JA, Tscherne H. Pattern of organ failure following severe trauma. World J Surg 1996; 20: 422429.
  • 2
    Clemens MG, Bauer M, Pannen BH, Bauer I, Zhang JX. Remodeling of hepatic microvascular responsiveness after ischemia/reperfusion. Shock 1997; 8: 8085.
  • 3
    Pannen BH, Bauer M, Noldge-Schomburg GF, Zhang JX, Robotham JL, Clemens MG, Geiger KK. Regulation of hepatic blood flow during resuscitation from hemorrhagic shock: role of NO and endothelins. Am J Physiol 1997; 272: H2736H2745.
  • 4
    Bauer M, Pannen BH, Bauer I, Herzog C, Wanner GA, Hanselmann R, Zhang JX, et al. Evidence for a functional link between stress response and vascular control in hepatic portal circulation. Am J Physiol 1996; 271: G929G935.
  • 5
    Rensing H, Bauer I, Datene V, Patau C, Pannen BH, Bauer M. Differential expression pattern of heme oxygenase-1/heat shock protein 32 and nitric oxide synthase-II and their impact on liver injury in a rat model of hemorrhage and resuscitation. Crit Care Med 1999; 27: 27662775.
  • 6
    Suematsu M, Wakabayashi Y, Ishimura Y. Gaseous monoxides: a new class of microvascular regulator in the liver. Cardiovasc Res 1996; 32: 679686.
  • 7
    Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J 1988; 2: 25572568.
  • 8
    Bauer I, Wanner GA, Rensing H, Alte C, Miescher EA, Wolf B, Pannen BH, et al. Expression pattern of heme oxygenase isoenzymes 1 and 2 in normal and stress-exposed rat liver. Hepatology 1998; 27: 829838.
  • 9
    Goda N, Suzuki K, Naito M, Takeoka S, Tsuchida E, Ishimura Y, Tamatani T, et al. Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation. J Clin Invest 1998; 101: 604612.
  • 10
    Rensing H, Bauer I, Peters I, Wein T, Silomon M, Jaeschke H, Bauer M. Role of reactive oxygen species for hepatocellular injury and heme oxygenase-1 gene expression after hemorrhage and resuscitation. Shock 1999; 12: 300308.
  • 11
    Pannen BH, Bauer M. Differential regulation of hepatic arterial and portal venous vascular resistance by nitric oxide and carbon monoxide in rats. Life Sci 1998; 62: 20252033.
  • 12
    Suematsu M, Goda N, Sano T, Kashiwagi S, Egawa T, Shinoda Y, Ishimura Y. Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. J Clin Invest 1995; 96: 24312437.
  • 13
    Pannen BH, Kohler N, Hole B, Bauer M, Clemens MG, Geiger KK. Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats. J Clin Invest 1998; 102: 12201228.
  • 14
    Rensing H, Jaeschke H, Bauer I, Patau C, Datene V, Pannen BH, Bauer M. Differential activation pattern of redox-sensitive transcription factors and stress-inducible dilator systems heme oxygenase-1 and inducible nitric oxide synthase in hemorrhagic and endotoxic shock. Crit Care Med 2001; 29: 19621971.
  • 15
    Zhang JX, Pegoli W, Clemens MG. Endothelin-1 induces direct constriction of hepatic sinusoids. Am J Physiol 1994; 266: G624G632.
  • 16
    Bauer M, Zhang JX, Bauer I, Clemens MG. ET-1 induced alterations of hepatic microcirculation: sinusoidal and extrasinusoidal sites of action. Am J Physiol 1994; 267: G143G149.
  • 17
    Kawana M, Lee ME, Quertermous EE, Quertermous T. Cooperative interaction of GATA-2 and AP1 regulates transcription of the endothelin-1 gene. Mol Cell Biol 1995; 15: 42254231.
  • 18
    Yamashita K, Discher DJ, Hu J, Bishopric NH, Webster KA. Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. J Biol Chem 2001; 276: 1264512653.
  • 19
    Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156159.
  • 20
    Zimmerhackl B, Parekh N, Brinkhus H, Steinhausen M. The use of fluorescent labeled erythrocytes for intravital investigation of flow and local hematocrit in glomerular capillaries in the rat. Int J Microcirc Clin Exp 1983; 2: 119129.
  • 21
    Bauer M, Bauer I, Sonin NV, Kresge N, Baveja R, Yokoyama Y, Harding D, et al. Functional significance of endothelin B receptors in mediating sinusoidal and extrasinusoidal effects of endothelins in the intact rat liver. Hepatology 2000; 31: 937947.
  • 22
    Bauer M, Paquette NC, Zhang JX, Bauer I, Pannen BH, Kleeberger SR, Clemens MG. Chronic ethanol consumption increases hepatic sinusoidal contractile response to endothelin-1 in the rat. Hepatology 1995; 22: 15651576.
  • 23
    Ignarro LJ, Ballot B, Wood KS. Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins. J Biol Chem 1984; 259: 62016207.
  • 24
    Serfass L, Burstyn JN. Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity. Arch Biochem Biophys 1998; 359: 816.
  • 25
    Sonin NV, Garcia-Pagan JC, Nakanishi K, Zhang JX, Clemens MG. Patterns of vasoregulatory gene expression in the liver response to ischemia/reperfusion and endotoxemia. Shock 1999; 11: 175179.
  • 26
    Yokoyama Y, Baveja R, Sonin N, Nakanishi K, Zhang JX, Clemens MG. Altered endothelin receptor subtype expression in hepatic injury after ischemia/reperfusion. Shock 2000; 13: 7278.
  • 27
    Housset C, Rockey DC, Bissell DM. Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1. Proc Natl Acad Sci U S A 1993; 90: 92669270.
  • 28
    Kawada N, Tran-Thi TA, Klein H, Decker K. The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus. Eur J Biochem 1993; 213: 815823.
  • 29
    Pinzani M, Failli P, Ruocco C, Casini A, Milani S, Baldi E, Giotti A, et al. Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients. J Clin Invest 1992; 90: 642646.
  • 30
    Rockey DC, Housset CN, Friedman SL. Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. J Clin Invest 1993; 92: 17951804.
  • 31
    Pannen BH, Bauer M, Zhang JX, Robotham JL, Clemens MG. A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin. Am J Physiol 1996; 271: H1953H1961.
  • 32
    Zhang JX, Bauer M, Clemens MG. Vessel- and target cell-specific actions of endothelin-1 and endothelin-3 in rat liver. Am J Physiol 1995; 269: G269G277.
  • 33
    Wakabayashi Y, Takamiya R, Mizuki A, Kyokane T, Goda N, Yamaguchi T, Takeoka S, et al. Carbon monoxide overproduced by heme oxygenase-1 causes a reduction of vascular resistance in perfused rat liver. Am J Physiol 1999; 277: G1088G1096.
  • 34
    Clemens MG, Zhang JX. Regulation of sinusoidal perfusion: in vivo methodology and control by endothelins. Semin Liver Dis 1999; 19: 383396.
  • 35
    McCuskey RS. Morphological mechanisms for regulating blood flow through hepatic sinusoids. Liver 2000; 20: 37.