Liver Biology and Pathobiology
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Hepatoma-derived growth factor is highly expressed in developing liver and promotes fetal hepatocyte proliferation
Article first published online: 7 MAR 2007
DOI: 10.1002/hep.1840360629
Copyright © 2002 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Enomoto, H., Yoshida, K., Kishima, Y., Kinoshita, T., Yamamoto, M., Everett, A. D., Miyajima, A. and Nakamura, H. (2002), Hepatoma-derived growth factor is highly expressed in developing liver and promotes fetal hepatocyte proliferation. Hepatology, 36: 1519–1527. doi: 10.1002/hep.1840360629
Publication History
- Issue published online: 7 MAR 2007
- Article first published online: 7 MAR 2007
- Manuscript Accepted: 7 SEP 2002
- Manuscript Received: 19 FEB 2002
Funded by
- Scientific Research of the Ministry of Education, Culture, Sports, Science, and Technology of Japan
Reference
- 1
- 2, Hepatocyte differentiation initiates during endodermal-mesenchymal interactions prior to liver formation. Development 1991; 113: 217–225.
- 3, , Cell lineages and oval cell progenitors in rat liver development. Cancer Res 1991; 51: 2611–2620.
- 4, Transcriptional control of the murine albumin/α-fetoprotein locus during development. Proc Natl Acad Sci U S A 1982; 79: 5254–5257.
- 5The developmental formation of enzymes in rat liver. In: LitwackG, ed. Biochemical Actions of Hormones. New York: Academic Press, 1970: 53–87.
- 6, , , , , High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes. J Clin Invest 1995; 95: 832–841.
- 7, , Developmental and growth-related regulation of expression of serine dehydratase mRNA in rat liver. Biochem Biophys Res Commun 1990; 168: 335–342.
- 8, Liver regeneration. Science 1997; 276: 60–66.
- 9, , Transcriptional regulatory signals define cytokine-dependent and -independent pathways in liver regeneration. Semin Liver Dis 1999; 19: 117–127.
- 10Mouse liver tumorigenesis: models, mechanisms, and relevance to human disease. Semin Liver Dis 1999; 19: 243–252.
- 11
- 12, , , , , , Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 1995; 373: 702–705.
- 13, , , , , , , et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 1995; 373: 699–702.
- 14, , , . Is essential for normal mouse development and hepatogenesis. Nature 1993; 365: 179–181.
- 15, , , , Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kB. Nature 1995; 376: 167–170.
- 16, , , , , , , et al. Partial purification and characterization of human hepatoma-derived growth factor. Clin Chim Acta 1989; 183: 273–284.
- 17, , , , , , , et al. Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein. J Biol Chem 1994; 269: 25143–25149.
- 18, An endothelial growth factor involved in rat renal development. J Clin Inves 1998; 102: 1208–1219.
- 19, , , , Hepatoma-derived growth factor stimulates smooth muscle cell growth and is expressed in vascular development. J Clin Invest 2000; 105: 567–575.
- 20, , , , Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus. Biochem Biophys Res Commun 1997; 238: 26–32.
- 21, , , , , , , et al. A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus. Biochem Biophys Res Commun 2000; 266: 81–87.
- 22, , Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. EMBO J 1998; 17: 6723–6729.
- 23, , , Lens epithelium-derived growth factor: increased resistance to thermal and oxidative stresses. Invest Ophthalmol Vis Sci 1999; 40: 1444–1451.
- 24, , , , , , , et al. Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J 1999; 18: 2127–2136.
- 25, , , , , , , et al. Cbfa 1 is a positive regulatory factor in chondrocyte maturation. J Biol Chem 2000; 275: 8695–8702.
- 26, Adenovirus-mediated transfer of low-density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci U S A 1993; 90: 2812–2816.
- 27, , A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology 1988; 163: 614–617.
- 28, , , , , , , et al. Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. Proc Natl Acad Sci U S A 1999; 96: 7265–7270.
- 29, , , , Expression of transforming growth factor-α in regenerating liver and during hepatic differentiation. Mol Carcinog 1992; 5: 25–31.Direct Link:
- 30, , , , Expression of hepatocyte growth factor and c-met genes during hepatic differentiation and liver development in the rat. Am J Pathol 1993; 142: 1823–1830.
- 31, , , Developmental changes in hepatocyte growth factor mRNA and its receptor in rat liver, kidney and lung. Eur J Biochem 1992; 210: 375–380.Direct Link:
- 32, , Epidermal growth factor receptor mRNA in livers from newborn, adult and partially hepatectomized rats. Endocrinol Jpn 1990; 37: 431–435.
- 33, , , Mitogen-independent DNA synthesis by fetal rat hepatocytes in primary culture. Exp Cell Res 1993; 209: 53–57.
- 34, , Autocrine mechanism of growth of neonatal rat hepatocytes in primary culture. J Biochem 1988; 103: 700–706.
- 35, , , Growth stimulation of rat fetal hepatocytes in response to hepatocyte growth factor:modulation of c-myc and c-fos expression. Biochem Biophys Res Commun 1992; 189: 684–690.
- 36, , , , , , , et al. Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver. Hepatology 2000; 32: 1230–1239.Direct Link:
- 37, , , , , , , et al. Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals. J Biol Chem 2002; 277: 10315–10322.

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