• 1
    Vlahcevic ZR, Pandak WM, Stravitz RT. Regulation of bile acid biosynthesis. Gastroenterol Clin North Am 1999; 28: 125.
  • 2
    Russell DW, Setchell KD. Bile acid biosynthesis. Biochemistry 1992; 31: 47374749.
  • 3
    Hylemon P, Pandak WM, Vlahcevic ZR. Regulation of hepatic cholesterol homeostasis. In: AriasIM, BoyerJL, ChisariFV, FaustoN, SchachterD, ShafritzDA. eds. The liver: biology and pathobiology. Philadelphia: Lippincott Williams & Wilkins, 2001: 231247.
  • 4
    Duane WC, Javitt NB. 27-hydroxycholesterol: production rates in normal human subjects. J Lipid Res 1999; 40: 11941199.
  • 5
    Axelson M, Mork B, Aly A, Wisen O, Sjovall J. Concentrations of cholestenoic acids in plasma from patients with liver disease. J Lipid Res 1989; 30: 18771882.
  • 6
    Javitt NB. 25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles. J Lipid Res 2002; 43: 665670.
  • 7
    Pandak WM, Li YC, Chiang JY, Studer EJ, Gurley EC, Heuman DM, et al. Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat. J Biol Chem 1991; 266: 34163421.
  • 8
    Pandak WM, Schwarz C, Hylemon PB, Mallonee D, Valerie K, Heuman DM, et al. Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis. Am J Physiol Gastrointest Liver 2001; 281: G878G889.
  • 9
    Arakane F, Kallen CB, Watari H, Stayrook SE, Lewis M, Strauss JF. Steroidogenic acute regulatory protein (StAR) acts on the outside of mitochondria to stimulate steroidogenesis. Endocr Res 1998; 24: 463468.
  • 10
    Bose HS, Whittal RM, Huang MC, Baldwin MA, Miller WL. N-218 MLN64, a protein with StAR-like steroidogenic activity, is folded and cleaved similarly to StAR. Biochemistry 2000; 39: 1172211731.
  • 11
    Gallegos AM, Atshaves BP, Storey SM, Starodub O, Petrescu AD, Huang H, et al. Gene structure, intracellular localization, and functional roles of sterol carrier protein-2. Prog Lipid Res 2001; 40: 498563.
  • 12
    Strauss JF, Kallen CB, Christenson LK, Watari H, Devote L, Arakane F, et al. The steroidogenic acute regulatory protein (StAR): a window into the complexities of intracellular cholesterol trafficking. Recent Prog Horm Res 1999; 54: 369394.
  • 13
    Christenson LK, Strauss JF. Steroidogenic acute regulatory protein (StAR) and the intramitochondrial translocation of cholesterol. Biochim Biophys Acta 2000; 1529: 175187.
  • 14
    Stocco DM. The role of the StAR protein in steroidogenesis: challenges for the future. J Endocrinol 2000; 164: 247253.
  • 15
    Pandak WM, Ren S, Marques D, Hall E, Redford K, Mallonee D, et al. Transport of cholesterol into mitochondria is rate limiting for bile acid synthesis via the acidic pathway in primary rat hepatocytes. J Biol Chem 2002; 277: 4815848164.
  • 16
    Pandak WM, Heuman DM, Redford K, Stravitz RT, Chiang JY, Hylemon PB, et al. Hormonal regulation of cholesterol 7alpha-hydroxylase specific activity, mRNA levels, and transcriptional activity in vivo in the rat. J Lipid Res 1997; 38: 24832491.
  • 17
    Ren S, Marques D, Redford K, Hylemon PB, Gil G, Vlahcevic ZR, et al. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat. Metabolism 2003; 52: 636642.
  • 18
    Stravitz RT, Rao YP, Vlahcevic ZR, Gurley EC, Jarvis WD, Hylemon PB. Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase. Am J Physiol 1996; 271: G293G303.
  • 19
    Miller WL, Strauss JF. Molecular pathology and mechanism of action of the steroidogenic acute regulatory protein, StAR. J Steroid Biochem Mol Biol 1999; 69: 131141.
  • 20
    Stocco DM. StARTing to understand cholesterol transfer. Nat Struct Biol 2000; 7: 445447.
  • 21
    Nishikawa T, Omura M, Suematsu S. Possible involvement of calcium/calmodulin-dependent protein kinase in ACTH-induced expression of the steroidogenic acute regulatory (StAR) protein in bovine adrenal fasciculata cells. Endocr J 1997; 44: 895898.