• 1
    Higgins GM, Anderson RM. Experimental pathology of the liver I. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931; 12: 186202.
  • 2
    Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997; 276: 6066.
  • 3
    Yamada Y, Kirillova I, Peschon JJ, Fausto N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci U S A 1997; 94: 14411446.
  • 4
    Cressmann DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V, et al. Liver failure and defective hepatocyte regeneration in interleukin-6 deficient mice. Science 1996; 274: 13791383.
  • 5
    Akerman P, Cote P, Yang SQ, McClain C, Nelson S, Bagby GJ, et al. Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am J Physiol 1992; 263: G579G585.
  • 6
    Bucher NL, Swaffield MN, Di Troia JF. The influence of age upon the incorporation of thymidine-2-C14 into the DNA of regenerating rat liver. Cancer Res 1964; 24: 509512.
  • 7
    Stocker E, Heine WD. Regeneration of liver parenchyma under normal and pathological conditions. Mol Cell Biol 1971; 144: 400408.
  • 8
    Fry MF, Silber J, Loeb LA, Martin GM. Delayed and reduced cell replication and diminishing levels of DNA polymerases-alpha in regenerating liver of aging mice. J Cell Physiol 1984; 118: 225232.
  • 9
    Ye H, Holterman AX, Yoo KW, Franks RR, Costa RH. Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase. Mol Cell Biol 1999; 19: 85708580.
  • 10
    Wang X, Kiyokawa H, Dennewitz M, Costa RH. The Forkhead box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc Natl Acad Sci U S A 2002; 99: 1688116886.
  • 11
    Wang X, Quail E, Hung NJ, Tan Y, Ye H, Costa RH. Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver. Proc Natl Acad Sci U S A 2001; 98: 1146811473.
  • 12
    Wang X, Krupczak-Hollis, Tan Y, Dennewitz MB, Adami GR, Costa RH. Increased hepatic Forkhead Box M1B (Fox M1B) levels in old-aged mice stimulated liver regeneration through diminished p27kip1 protein levels and increased Cdc25B expression. J Biol Chem 2002; 277: 4431044316.
  • 13
    Columbano A, Shinozuka H. Liver regeneration versus direct hyperplasia. FASEB J 1996; 10: 11181128.
  • 14
    Ledda-Columbano GM, Columbano A. Mitogenesis by ligands of nuclear receptors: an attractive model for the study of the molecular mechanisms implicated in liver growth. Cell Death Differ 2003; 10 (Suppl 1):S19–S21.
  • 15
    Pibiri M, Ledda-Columbano GM, Cossu C, Simbula G, Menegazzi G, Shinozuka H, et al. Cyclin D1 is an early target in hepatocyte proliferation induced by thyroid hormone (T3). FASEB J 2001; 15: 10061013.
  • 16
    Ledda-Columbano GM, Pibiri M, Loi R, Perra A, Shinozuka H, Columbano A. Early increase in cyclin D1 expression and accelerated entry of mouse hepatocytes into S phase after administration of the mitogen 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. Am J Pathol 2000; 56: 9197.
  • 17
    Ledda-Columbano GM, Curto M, Piga R, Zedda AI, Menegazzi M, Sartori C, et al. In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway. Oncogene 1998; 17: 10391044.
  • 18
    Locker J, Tian J, Carter R, Concas D, Cossu C, Ledda-Columbano GM, et al. A common set of immediate-early response genes in liver regeneration and hyperplasia. Hepatology 2003; 38: 314325.
  • 19
    Timchenko NA, Wilde M, Nakanishi M, Smith JR, Darlington GJ. CCATT/enhancer binding protein alpha (C/EBPalpha) inhibits cell proliferation through the p21 (WAF-1/Cip-1/SD-1) protein. Genes Dev 1996; 10: 804815.
  • 20
    Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 1976; 72: 248254.
  • 21
    Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P, Negishi M. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem 1999; 274: 60436046.
  • 22
    Tzameli I, Pissios P, Schuetz EG, Moore DD. The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridiloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol Cell Biol 2000; 20: 29512958.
  • 23
    Honkakoski P, Moore R, Washburn KA, Negishi M. Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene. Mol Pharmacol 1998; 53: 597601.
  • 24
    De Smaele E, Zazzeroni F, Papa S, Nguyen DU, Jin R, Jones J, et al. Induction of gadd45beta by NF-kappaB downregulates proapoptotic JNK signalling. Nature 2001; 414: 308312.
  • 25
    Columbano A, Ledda-Columbano GM, Pibiri M, Piga R, Shinozuka H, De Luca V, et al. Increased expression of c-fos, c-jun and LRF-1 is not required for in vivo priming of hepatocytes by the mitogen TCPOBOP. Oncogene 1997; 14: 857863.
  • 26
    Herwig S, Strauss M. The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis. Eur J Biochem 1997; 15: 581601.
  • 27
    Sherr CJ. Cancer cell cycles. Science 1996; 274: 16721677.
  • 28
    Calbo J, Parreno M, Sotillo E, Yong T, Mazo A, Garriga J, et al. G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression. J Biol Chem 2002; 52: 5026350274.
  • 29
    Wang X, Hung NJ, Costa RH. Earlier expression of the transcription factor HFH 11B (FOXM1B) diminishes induction of p21CIP/WAF1 levels and accelerates mouse hepatocyte entry into S-phase following carbon tetrachloride liver injury. Hepatology 2001; 33: 14041414.
  • 30
    Krupczak-Hollis K, Wang X, Dennewitz MB, Costa RH. Growth hormone stimulates proliferation of old-aged regenerating liver through fork-head box m1b. Hepatology 2003; 38: 15521562.