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Acetaminophen misconceptions
Article first published online: 30 JUN 2004
DOI: 10.1002/hep.20300
Copyright © 2004 American Association for the Study of Liver Diseases
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How to Cite
Rumack, B. H. (2004), Acetaminophen misconceptions. Hepatology, 40: 10–15. doi: 10.1002/hep.20300
Publication History
- Issue published online: 30 JUN 2004
- Article first published online: 30 JUN 2004
- Manuscript Accepted: 10 APR 2004
- Manuscript Received: 8 MAR 2004
- Abstract
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Abstract
Examination of the pharmacokinetics of acetaminophen can decrease misconceptions involved in clinical evaluation. Enzyme patterns and acetaminophen levels must be related to time and known metabolic phenomena. A careful look at ethanol and nutrition, especially fasting demonstrates that therapeutic doses of acetaminophen do not place patients at a greater risk in either of these instances. An overdose of acetaminophen in a chronic alcohol abuser may result in more severe hepatotoxicity than in the nonalcoholic. CYP2E1 and glutathione must be evaluated simultaneously rather than in isolation. Glucuronidation capacity in humans is not a factor except in massively overdosed patients. (HEPATOLOGY 2004;40:10–15.)