• 1
    Hoofnagle JH, Bisceglie S. Serologic diagnosis of acute and chronic hepatitis. Semin Liver Dis 1991; 11: 7383.
  • 2
    Mushahwar IK, Dienstag JL, Polesky HF, McGrath LC, Decker RH, Overby LR. Interpretation of various serological profiles of hepatitis B virus infection. Am J Clin Pathol 1981; 76: 773777.
  • 3
    Lemon SM, Gales NL, Simms TE, Bancruft WH. IgM antibody to hepatitis B core antigen as a diagnostic parameter of acute infection with hepatitis B virus. J Infect Dis 1981; 143: 803809.
  • 4
    Lok ASF, Lai CL, Wu PC. Prevalence of isolated antibody to hepatitis B core antigen in an area endemic for hepatitis B virus infection: implications in hepatitis B vaccination programs. HEPATOLOGY 1988; 8: 766770.
  • 5
    Grob P, Jilg W, Bornhak H, Gerken G, Gerlich W, Günther S, et al. Serological pattern ‘anti-HBc alone’: report on a workshop. J Med Virol 2000; 62: 450455.
  • 6
    Caspari G, Beyer HJ, Elbert G, Koerner K, Muss P, Schunter FW, et al. Unsatisfactory specificities and sensitivities of six enzyme immunoassays for antibodies to hepatitis B core antigen. J Clin Microbiol 1989; 27: 20672072.
  • 7
    McMahon BJ, Parkinson AJ, Helminiak C, Wainwright RB, Bulkow L, Kellerman-Douglas A, et al. Response of hepatitis B vaccine of persons positive for antibody to hepatitis B core antigen. Gastroenterology 1992; 103: 590594.
  • 8
    Marusawa H, Uemoto S, Hijikata M, Ueda Y, Tanaka K, Shimotohno K, et al. Latent hepatitis virus infection in healthy individuals with antibodies to hepatitis B core antigen. HEPATOLOGY 2000; 31: 488495.
  • 9
    Bréchot C, Thiers V, Kremsdorf D, Nalpas B, Paterlini-Brechot P. Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely occult? HEPATOLOGY 2001; 34: 194203.
  • 10
    Conjeevaram H, Lok AS. Occult hepatitis B virus infection: a hidden menace? HEPATOLOGY 2001; 34: 204206.
  • 11
    Tseng K-C, Lei H-Y, Cheng P-N, Young K-C, Jen C-M, Wu C-H, et al. Immune response to hepatitis B vaccine of subjects with isolated antibody to hepatitis B core antigen. Hepatogastroenterology 2003; 50: 14741477.
  • 12
    Michalak T I, Pasquinelli C, Guilhot S, Chisari FV. Hepatitis B virus persistence after recovery from acute viral hepatitis. J Clin Invest 1994; 93: 230239.
  • 13
    Penna A, Artini M, Caballi A, Levrero M, Bertoletti A, Pilli M, et al. Long-lasting memory T cell responses following self-limited acute hepatitis B. J Clin Invest 1996; 98: 11851194.
  • 14
    Rehermann B, Ferrari C, Pasquinelli C, Chisari FV. The hepatitis B virus persists for decades after patient's recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med 1996; 2: 11041108.
  • 15
    Hoofnagle J H, Seeff LB, Buskell-Bales ZB, Zimmerman HJ, the Veteran Administration Hepatitis Cooperative Study Group. Type B hepatitis after transfusion with blood containing antibody to hepatitis B core antigen. N Engl J Med 1978; 298: 13791383.
  • 16
    Wachs ME, Amend WJ, Ascher NL, Bretan PN, Emond J, Lake JR, et al. The risk of transmission of hepatitis B from HBsAg(−), HBcAb (+), HBIgM(−) organ donors. Transplantation 1995; 59: 230234.
  • 17
    Lowell JA, Howard TK, White HM, Shenoy S, Huettner PC, Brennan DC, et al. Serological evidence of past hepatitis B infection in liver donor and hepatitis B infection in liver allograft. Lancet 1995; 345: 10841085.
  • 18
    Uemoto S, Sugiyama K, Marusawa H, Inomata, Y, Asonuma K, Egawa H, et al. Transmission of hepatitis B virus from hepatitis B core antibody-positive donors in living related liver transplants. Transplantation 1998; 65: 494499.
  • 19
    Prieto M, Gomez MD, Berenguer M, Cordoba J, Rayon JM, Pastor M, et al. De novo hepatitis B after liver transplantation from hepatitis B core antibody-positive donors in an area with high prevalence of anti-HBc positivity in donor population. Liver Transplant 2001; 7: 5158.
  • 20
    Muñoz SJ. Use of hepatitis B core antibody-positive donors for liver transplantation. Liver Transplant 2002; 8( Suppl): S82S87.
  • 21
    Ghisetti V, Marzano A, Zamboni F, Barbui A, Franchello A, Gaia S, et al. Occult hepatitis B virus infection in HBsAg negative patients undergoing liver transplantation: clinical significance. Liver Transplant 2004; 10: 356362.
  • 22
    Lok AS, Liang RH, Chiu EK, Wong KL, Chan TK, Todd D. Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy: report of a prospective study. Gastroenterology 1991; 100: 14321434.
  • 23
    Larghi A, Leffler D, Frucht H, Rubin M, Semrad CE, Lefkowitch JH, et al. Hepatitis B virus reactivation after kidney transplantation and new onset lymphoma. J Clin Gastroenterol 2003; 36: 276280.
  • 24
    Paterlini P, Gerken G, Nakajima E, Terre S, D'Errico A, Grigioni W, et al. Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen. N Engl J Med 1990; 323: 8085.
  • 25
    Blum HE, Liang TJ, Galun E, Wands JR. Persistence of hepatitis B viral DNA after serological recovery from hepatitis B virus infection. HEPATOLOGY 1991; 14: 5663.
  • 26
    Yotsuyanagi H, Shintani Y, Moriya K, Fujie H, Tsutsumi T, Kato T, et al. Virologic analysis of non-B, non-C hepatocellular carcinoma in Japan: frequent involvement of hepatitis B virus. J Infect Dis 2000; 181: 19201928.
  • 27
    Pollicino T, Squadrito G, Cerenzia G, Cacciola I, Raffa G, Crax A, et al. Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection. Gastroenterology 2004; 126: 102110.
  • 28
    Tennant BC, Gerin JL. The woodchuck model of hepatitis B virus infection. In: AriasIM, BoyerJL, FaustoN, JakobyWB, SchachterDA, ShafritzDA, eds. The liver: biology and pathobiology. New York: Raven Press, 1994: 14551466.
  • 29
    Michalak TI. The woodchuck animal model of hepatitis B. Viral Hepatitis Rev 1998; 4: 139165.
  • 30
    Michalak TI, Pardoe I U, Coffin CS, Churchill ND, Freake DS, Smith P, et al. Occult life-long persistence of infectious hepadnavirus and residual liver inflammation in woodchucks convalescent from acute viral hepatitis. HEPATOLOGY 1999; 29: 928938.
  • 31
    Coffin CS, Michalak TI. Persistence of infectious virus in the offspring of woodchuck mothers recovered from viral hepatitis. J Clin Invest 1999; 104: 203212.
  • 32
    Lew Y-Y, Michalak TI. In vitro and in vivo infectivity and pathogenicity of the lymphoid cell-derived woodchuck hepatitis virus. J Virol 2001; 75: 17701782.
  • 33
    Michalak TI, Mulrooney PM, Coffin CS. Low doses of hepadnavirus induce infection of the lymphatic system that does not engage the liver. J Virol 2004; 78: 17301738.
  • 34
    Jin Y-M, Churchill ND, Michalak TI. Protease-activated lymphoid cell and hepatocyte recognition site in the preS1 domain of the large woodchuck hepatitis virus envelope protein. J Gen Virol 1996; 77: 18371846.
  • 35
    Pardoe IU, Michalak TI. Detection of hepatitis B and woodchuck hepatitis viral DNA in plasma and mononuclear cells from heparinized blood by the polymerase chain reaction. J Virol Meth 1995; 51: 277288.
  • 36
    Michalak TI, Lin B, Churchill ND, Dzwonkowski P, Desousa JRB. Hepadna virus nucleocapsid and surface antigens and the antigen-specific antibodies associated with hepatocyte plasma membranes in experimental woodchuck acute hepatitis. Lab Invest 1990; 62: 680689.
  • 37
    Hodgson PD, Michalak TI. Augmented hepatic interferon gamma expression and T-cell influx characterize acute hepatitis progressing to recovery and residual lifelong virus persistence in experimental adult woodchuck hepatitis virus infection. HEPATOLOGY 2001; 34: 10491059.
  • 38
    Diao J, Slaney DM, Michalak TI. Modulation of the outcome and severity of hepadnaviral hepatitis in woodchucks by antibodies to hepatic asialoglycoprotein receptor. HEPATOLOGY 2003; 38; 629638.
  • 39
    Michalak TI. Occult persistence and lymphotropism of hepadnaviral infection: insights from the woodchuck viral hepatitis model. Immunol Rev 2000; 174: 98111.
  • 40
    Mulrooney PM, Michalak TI. Quantitative detection of hepadnavirus-infected lymphoid cells by in situ PCR combined with flow cytometry: implications for the study of occult virus persistence. J Virol 2003; 77: 970979.
  • 41
    Yuki N, Nagaoka T, Yamashiro M, Mochizuki K, Kaneko A, Yamamoto K, et al. Long-term histologic and virologic outcomes of acute self-limited hepatitis B. HEPATOLOGY 2003; 37: 11721179.
  • 42
    Thiers V, Nakajima E, Kremsdorf D, Mack D, Schellekens H, Driss F, et al. Transmission of hepatitis B from hepatitis B-seronegative subjects. Lancet 1988; ii: 12731276.
  • 43
    Larsen J, Hetland G, Skaug K. Posttransfusion hepatitis B transmitted by blood from a hepatitis B surface-negative hepatitis B virus carrier. Transfusion 1990; 30: 431432.
  • 44
    Schifman RB, Rivers SL, Sampliner RE, Krammes JE. Significance of isolated hepatitis B core antibody in blood donors. Arch Intern Med 1993; 153: 22612266.