H.H.H. is an investigator for the Howard Hughes Medical Institute.
Liver Failure and Liver Disease
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Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
Article first published online: 24 NOV 2004
DOI: 10.1002/hep.20466
Copyright © 2004 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M. and Hobbs, H. H. (2004), Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology, 40: 1387–1395. doi: 10.1002/hep.20466
- †
H.H.H. is an investigator for the Howard Hughes Medical Institute.
- ‡
fax: 214-648-7539
Publication History
- Issue published online: 24 NOV 2004
- Article first published online: 24 NOV 2004
- Manuscript Accepted: 31 AUG 2004
- Manuscript Received: 29 JUN 2004
Funded by
- Donald W. Reynolds Cardiovascular Clinical Research Center at Dallas
- National Institutes of Health. Grant Number: HL-20948
- postdoctoral fellowship award from the American Liver Foundation and the National Institutes of Health training grant. Grant Number: T32-DK-07745
References
- 1, , . The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 2003; 98: 960–967.Direct Link:
- 2. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221–1231.
- 3, , . Hepatic morphology in obesity. Dig Dis Sci 1981; 26: 325–327.
- 4, , , , . Liver in obesity. Gut 1985; 26: 133–139.
- 5, , , , , , et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999; 107: 450–455.
- 6, . Fatty liver hepatitis (steatohepatitis) and obesity:an autopsy study with analysis of risk factors. HEPATOLOGY 1990; 12: 1106–1110.
- 7, , , . Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994; 107: 1103–1109.
- 8, , , , , , et al. Nonalcoholic fatty liver disease a feature of the metabolic syndrome. Diabetes 2001; 50: 1844–1850.
- 9, . Steatohepatitis: a tale of two “hits”? Gastroenterology 1998; 114: 842–845.
- 10, , , , . Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999; 94: 2467–2474.Direct Link:
- 11, , . Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones. J Hepatol 2001; 35: 17–23.
- 12, , , , . Noninvasive assessment of hepatic triglyceride content in humans with 13C nuclear magnetic resonance spectroscopy. HEPATOLOGY 1996; 24: 114–117.
- 13, , , , , , et al. The utility of radiological imaging in nonalcohlic fatty liver disease. Gastroenterology 2002; 123: 745–750.
- 14, , , , , , et al. Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis. J Magn Reson Imaging 1995; 5: 281–285.
- 15, , , . Liver histology in a “normal” population—examination of 503 consecutive fatal traffic casualties. Scand J Gastroenterol 1977; 12: 593–597.
- 16, , , , . The natural history of nonalcoholic fatty liver: a follow-up study. HEPATOLOGY 1995; 22: 1714–1719.
- 17, , , , , , et al. Prevalence of and risk factors for hepatic steatosis in northern Italy. Ann Intern Med 2000; 132: 112–117.
- 18, , , . Is NASH underdiagnosed among African Americans? Am J Gastroenterol 2002; 97: 1496–1500.Direct Link:
- 19, , , . Ethnic differences in the prevalence of cryptogenic cirrhosis. Am J Gastroenterol 2004; 99: 292–298.Direct Link:
- 20, , , , , , et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab. Published online August 31, 2004, doi 10:1152/ajpendo.00064. 2004.
- 21, , , , , , et al. The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health. Am J Cardiol 2004; 93: 1473–1480.
- 22Institute for Survey Research. Technical Report for the 1995 National Alcohol Survey. Philadelphia, PA: Temple University, 1996.
- 23Anonymous. Plan and Operation of the Third National Health and Nutrition Examination Survey. Washington, DC: National Center for Health Statistics, 1994.
- 24, , . Use and abuse of HOMA modeling. Diabetes Care 2004; 27: 1487–1495.
- 25, . Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539–553.
- 26, , , , , , et al. Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol Endocrinol Metab 1999; 276: E977–E989.
- 27, , , , , , et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002; 137: 1–10.
- 28, . Nonalcoholic fatty liver disease. In: FeldmanM, FriedmanLS, Sleisenger, MH, eds. Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. Volume 2. 7th ed. Philadelphia: Saunders, 2002: 1393–1400.
- 29, , , , , . Quantification of liver fat using magnetic resonance spectroscopy. Magn Reson Imaging 1994; 12: 487–495.
- 30, , , , , , et al. Fatty infiltration of the liver. Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography. Invest Radiol 1993; 28: 297–302.
- 31, , , , , , et al. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes 2002; 51: 797–802.
- 32, , , , . Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy. Diabetes Care 2003; 26: 30–35.
- 33
- 34, , , , , . Prevalence of fatty liver in a general population in Okinawa, Japan. Jpn J Med 1988; 27: 142–149.
- 35, , . Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001; 121: 91–100.
- 36, , . Light-to-moderate alcohol intake is associated with enhanced insulin sensitivity. Diabetes Care 1994; 17: 115–119.
- 37, , , , , , et al. Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study). BMJ 1996; 313: 1040–1044.
- 38, , , , , , et al. Sex difference in alcohol-related organ injury. Alcohol Clin Exp Res 2001; 25: 40S–45S.
- 39, . The biochemistry of alcohol-induced fatty liver. Biochem Biophys Acta 1994; 1215: 33–48.
- 40, , . Liver pathology in morbidly obese patients undergoing Roux-en-Y gastric bypass surgery. Obes Surg 2002; 12: 49–51.
- 41. Alcohol-related health disparities and treatment-related epidemiological findings among whites, blacks, and Hispanics in the United States. Alcohol Clin Exp Res 2003; 27: 1337–1339.
- 42. Cirrhosis in the alcoholic and its relation to the volume of alcohol abuse. Ann N Y Acad Sci 1975; 252: 85–105.
- 43, , , . Hepatitis C virus genotype 3 is cytopathic to hepatocytes:reversal of hepatic steatosis after sustained therapeutic response. HEPATOLOGY 2002; 36: 1266–1272.
- 44, , , , , . Prevalence of hepatitis B virus infection in the United States: the National Health and Nutrition Examination Surveys, 1976 through 1994. Am J Public Health 1999; 89: 14–18.
- 45, , , , , , et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med 1999; 341: 556–562.
- 46, , , , , , et al. Assessment of hepatitis C virus RNA and genotype from 6807 patients with chronic hepatitis C in the United States. J Viral Hepatol 2000; 7: 196–202.Direct Link:
- 47, , , , , , et al. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. FASEB J 2002; 16: 185–194.
- 48, , , , , . Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C. J Hepatol 2001; 34: 428–434.
- 49. Obesity, insulin resistance and diabetes—a worldwide epidemic. Br J Nutr 2000; 83: S5–S8.

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