fax: 858-554-8065
Viral Hepatitis
You have full text access to this OnlineOpen article
Epoetin alfa improves quality of life in anemic HCV-infected patients receiving combination therapy
Article first published online: 24 NOV 2004
DOI: 10.1002/hep.20482
Copyright © 2004 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Pockros, P. J., Shiffman, M. L., Schiff, E. R., Sulkowski, M. S., Younossi, Z., Dieterich, D. T., Wright, T. L., Mody, S. H., Tang, K. L., Goon, B. L., Bowers, P. J., Leitz, G. and Afdhal, N. H. (2004), Epoetin alfa improves quality of life in anemic HCV-infected patients receiving combination therapy. Hepatology, 40: 1450–1458. doi: 10.1002/hep.20482
Publication History
- Issue published online: 24 NOV 2004
- Article first published online: 24 NOV 2004
- Manuscript Accepted: 17 SEP 2004
- Manuscript Received: 30 JUN 2004
Funded by
- Ortho Biotech Clinical Affairs, LLC Bridgewater, NJ
References
- 1, , . The evaluation of two measures of quality of life in patients with type I and type II diabetes. Diabetes Care 1994; 17: 267–274.
- 2, , , , , . Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: improvements in hemoglobin and quality of life are similar to three-times-weekly dosing. J Clin Oncol 2001; 19: 2875–2882.
- 3, , , , . Relationship of health-related quality of life to treatment adherence and sustained response in chronic hepatitis C patients. HEPATOLOGY 2002; 35: 704–708.Direct Link:
- 4, , , . Health-related quality of life in chronic hepatitis C: impact of disease and treatment response. The Interventional Therapy Group. HEPATOLOGY 1999; 30: 550–555.Direct Link:
- 5, , , , . Effect of interferon alpha treatment of chronic hepatitis C on health-related quality of life. Dig Dis Sci 1997; 42: 2482–2486.
- 6, , , , , , et al. The effects of interferon alfa-2b in combination with ribavirin on health related quality of life and work productivity. J Hepatol 2001; 34: 140–147.
- 7, , , , , , et al. Relationship between changes in hemoglobin level and quality of life during chemotherapy in anemic patients receiving epoetin alfa therapy. Cancer 2002; 95: 888–895.Direct Link:
- 8Rebetron (Rebetol/Intron A) [package insert]. Kenilworth, NJ: Schering Corporation, 2003.
- 9, , , , . Changes in hemoglobin during interferon alfa-2b plus ribavirin therapy for chronic hepatitis C viral infection. J Viral Hepat 2004; 11: 243–250.Direct Link:
- 10, , , , , , et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975–982.
- 11, , , , , , et al. Premature discontinuation of interferon plus ribavirin for adverse effects: a multicentre study in “real world” patients with chronic hepatitis C. Aliment Pharmacol Ther 2002; 16: 1633–1639.Direct Link:
- 12, , , , , , et al. Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C. Gastroenterology 2002; 123: 1061–1069.
- 13, , , , , . Early virologic response to treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C. HEPATOLOGY 2003; 38: 645–652.Direct Link:
- 14, , , , , , et al. Peginterferon Alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment. Gastroenterology 2004; 126: 1015–1023.
- 15, , , , , , et al. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med 2004; 140: 346–355.
- 16, , , , , , et al. PROACTIVE Study Group. Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study. Gastroenterology 2004; 126: 1302–1311.
- 17, , , . SF-36 Health Survey Manual and Interpretation Guide. Boston, MA: The Health Institute, New England Medical Center, 1993.
- 18. The impact of anemia on quality of life in HIV-infected patients. J Infect Dis 2002; 185(Suppl 2): S110–S114.
- 19, , , , , , et al. Once-weekly epoetin alfa improves anemia and facilitates maintenance of ribavirin dosing in hepatitis C virus-infected patients receiving ribavirin plus interferon alfa. Am J Gastroenterol 2003; 98: 2491–2499.
- 20, . The Consensus Interferon Study Group. Reduction in health-related quality of life and improvement with interferon therapy. HEPATOLOGY 1999; 29: 264–270.Direct Link:
- 21, , . Assessment of fatigue and psychologic disturbances in patients with hepatitis C infection. J Clin Gastroenterol 2001; 32: 413–417.
- 22, , , , , , et al. Peg-interferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for intial treatment of chronic hepatitis C: a randomized trial. Lancet 2001; 358: 958–965.
- 23, , , , , . Determining clinically important differences in health status measures. Pharmacoeconomics 1999; 15: 141–155.
- 24, , , , . Epoetin Alfa Study Group. Assessing the clinical significance of health-related quality of life (HrQOL) improvements in anaemic cancer patients receiving epoetin alfa. Eur J Cancer 2003; 39: 335–345.
- 25, , , . Sustained virologic response is associated with improved health-related quality of life in relapsed chronic hepatitis C patients. Semin Liver Dis 1999; 19(Suppl 1): 77–85.

1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
1527-3350/asset/cover.gif?v=1&s=3cd983af6575c8dbfd6b47a63ffa95415ace15f8)