• 1
    Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Warkentin PI, et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med 1998; 338: 14221426.
  • 2
    Muraca M, Gerunda G, Neri D, Vilei MT, Granato A, Feltracco P, et al. Hepatocyte transplantation as a treatment for glycogen storage disease type 1a. Lancet 2002; 359: 317318.
  • 3
    Ohashi K, Park F, Kay MA. Hepatocyte transplantation: clinical and experimental application. J Mol Med 2001; 79: 617630.
  • 4
    Ponder KP, Gupta S, Leland F, Darlington G, Finegold M, DeMayo J, et al. Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci U S A 1991; 88: 12171221.
  • 5
    Gupta S, Chowdhury JR. Hepatocyte transplantation. In: AriasIM, BoyerJL, FaustoN, JakobyWB, SchachterD, ShafritzDA, eds. The Liver: Biology and Pathobiology. 3rd ed. New York, NY: Raven Press, 1994: 15191536.
  • 6
    Schneider A, Attaran M, Gratz KF, Bleck JS, Winkler M, Manns MP, et al. Intraportal infusion of 99mtechnetium-macro-aggregrated albumin particles and hepatocytes in rabbits: assessment of shunting and portal hemodynamic changes. Transplantation 2003; 75: 296302.
  • 7
    Griffith LG, Naughton G. Tissue engineering-current challenges and expanding opportunities. Science 2002; 295: 10091014.
  • 8
    Ohashi K, Marion PL, Nakai H, Meusu L, Cullen JM, Bordier BB, et al. Sustained survival of human hepatocytes in mice: a model for in vivo infection with human hepatitis B and hepatitis delta viruses. Nat Med 2000; 6: 327331.
  • 9
    Allen JW, Bhatia SN. Engineering liver therapies for the future. Tissue Eng 2002; 8: 725737.
  • 10
    Jirtle RL, Michalopoulos G. Effects of partial hepatectomy on transplanted hepatocytes. Cancer Res 1982; 42: 30003004.
  • 11
    Ricordi C, Lacy PE, Callery MP, Park PW, Flye MW. Trophic factors from pancreatic islets in combined hepatocyte-islet allografts enhance hepatocellular survival. Surgery 1989; 105(2 Pt 1): 218223.
  • 12
    Ohashi K, Meuse L, Schwall R, Kay MA. cMet activation allows persistent engraftment of ectopically transplanted xenogenic human hepatocytes in mice. Transplant Proc 2001; 33: 587588.
  • 13
    Bi L, Lawler AM, Antonarakis SE, High KA, Gearhart JD, Kazazian HH Jr. Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A. Nat Genet 1995; 10: 119121.
  • 14
    Shima M, Matsumoto T, Fukuda K, Kubota Y, Tanaka I, Nishiya K, et al. The utility of activated partial thromboplastin time (apt) clot waveform in the investigation of hemophilia A patients with very low levels of factor VIII activity (FVIII:C). Thromb Haemost 2002; 87: 436441.
  • 15
    Wang L, Zoppe M, Hackeng TM, Griffin JH, Lee KF, Verma IM. A factor IX-deficient mouse model for hemophilia B gene therapy. Proc Natl Acad Sci U S A 1997; 94: 1156311566.
  • 16
    Yuksel E, Weinfeld AB, Cleek R, Waugh JM, Jensen J, Boutros S, et al. De novo adipose tissue generation through long-term, local delivery of insulin and insulin-like growth factor-1 by PLGA/PEG microspheres in an in vivo rat model: a novel concept and capability. Plast Reconstr Surg 2000; 105: 17211729.
  • 17
    Elkins C, Waugh JM, Amabile PG, Minamiguchi H, Uy M, Sugimoto K, et al. Development of a platform to evaluate and limit in-stent restenosis. Tissue Engineering 2002; 8: 395407.
  • 18
    Ponder KP, Gupta S, Leland F, Darlington G, Finegold M, Demayo J, et al. Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci U S A 1991; 88: 12171221.
  • 19
    Ohashi K, Park F, Kay MA. Role of hepatocyte direct hyperplasia in lentivirus-mediated liver transduction in vivo. Hum Gene Ther 2002; 13: 653663.
  • 20
    Columbano A, Ledda-Columbano GM, Pibiri M, Piga R, Shinozuka H, DeLuca V, et al. Increased expression of c-fos, c-jun and LRF-1 is not required for in vivo priming of hepatocytes by the mitogen TCPOBOP. Oncogene 1997; 14: 857863.
  • 21
    Ohashi K, Tsutsumi M, Tsujiuchi T, Kobitsu K, Okajima E, Nakajima Y, et al. Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis caused by a colchicines-induced cell cycle disturbance in partially hepatectomized rats. Cancer Res 1996; 56: 34743479.
  • 22
    Bumgardner GL, Heininger M, Li J, Xia D, Parker-Thornburg J, Ferguson RM, et al. A functional model of hepatocyte transplantation for in vivo immunologic studies. Transplantation 1998; 65: 5361.
  • 23
    Passaniti A, Taylor RM, Pili R, Guo Y, Long PV, Haney JA, et al. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest 1992; 67: 519528.
  • 24
    Ajioka T, Akaike T, Watanabe Y. Expression of vascular endothelial growth factor promotes colonization, vascularization, and growth of transplanted hepatic tissues in the mouse. HEPATOLOGY 1999; 29: 396402.
  • 25
    Lee H, Cusick RA, Browne F, Ho Kim T, Ma PX, Utsunomiya H, et al. Local delivery of basic fibroblast growth factor increases both angiogenesis and engraftment of hepatocytes in tissue-engineered polymer devices. Transplantation 2002; 73: 15891593.
  • 26
    Bissell DM, Arenson DM, Maher JJ, Roll FJ. Support of cultured hepatocytes by a laminin-rich gel: evidence for a functionally significant subendothelial matrix in normal rat liver. J Clin Invest 1987; 79: 801812.
  • 27
    Mitaka T, Sato F, Mizuguchi T, Yokono T, Mochizuki Y. Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells. HEPATOLOGY 1999; 29: 111125.
  • 28
    Kumagai N, O'Neil JJ, Barth RN, LaMattina JC, Utsugi R, Moran SG, et al. Vascularized islet-cell transplantation in miniature swine. I. Preparation of vascularized islet kidneys. Transplantation 2002; 74: 12231230.
  • 29
    Runge D, Runge DM, Drenning SD, Bowen WC Jr, Grandis JR, Michalopoulos GK. Growth and differentiation of rat hepatocytes: changes in transcription factors HNF-3, HNF-4, STAT-3, and STAT-5. Biochem Biophys Res Commun 1998; 250: 762768.
  • 30
    Fridman R, Sweeney TM, Zain M, Martin GR, Kleinman HK. Malignant transformation of NIH-3T3 cells after subcutaneous co-injection with a reconstituted basement membrane (Matrigel). Int J Cancer 1992; 51: 740744.
  • 31
    Wion KL, Kelly D, Summerfield JA, Tuddenham EG, Lawn RM. Distribution of factor VIII mRNA and antigen in human liver and other tissues. Nature 1985; 317: 726729.
  • 32
    Wilde J, Teixeira P, Bramhall SR, Gunson B, Mutimer D, Mirza DF. Liver transplantation in haemophilia. Br J Haematol 2002; 117: 952956.
  • 33
    Horita K, Matsunami H, Shimizu Y, Shimizu A, Kurimoto M, Suzuki K, et al. Treatment of a patient with hemophilia A and hepatitis C virus-related cirrhosis by living-related liver transplantation from an obligate carrier donor. Transplantation 2002; 73: 19091912.
  • 34
    High KA. Gene therapy: a 2001 perspective. Hemophilia 2001; 7(Suppl 1): 2327.
  • 35
    Demetriou AA, Whiting JF, Feldman D, Levenson SM, Chowdhury NR, Moscioni AD, et al. Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes. Science 986; 233: 11901192.
  • 36
    Michalopoulos GK, DeFrancis ME. Liver regeneration. Science 1997; 276: 6066.
  • 37
    Ohashi K, Tsutsumi M, Nakajima Y, Kobitsu K, Nakano H, Konishi Y. Telomere changes in human hepatocellular carcinomas and hepatitis virus infected noncancerous livers. Cancer 1996; 77: S1747S1751.
  • 38
    Higgins GM, Anderson RM. Experimental pathology of the liver: restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931; 12: 186202.
  • 39
    Columbano A, Shinozuka H. Liver regeneration versus direct hyperplasia. FASEB J 1996; 10: 11181128.
  • 40
    Kaufmann PM, Sano K, Uyama S, Takeda T, Vacanti JP. Heterotopic hepatocyte transplantation: assessing the impact of hepatotrophic stimulation. Transplant Proc 1994; 26: 22402241.
  • 41
    Jones EA, Tosh D, Wilson DI, Lindsay S, Forrester LM. Hepatic differentiation of murine embryonic stem cells. Exp Cell Res 2002; 272: 1522.