Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection

Authors

  • Simona Urbani,

    1. Laboratory of Viral Immunopathology, Division of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Italy
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    • S.U. and C.B. contributed equally to this work.

  • Carolina Boni,

    1. Laboratory of Viral Immunopathology, Division of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Italy
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    • S.U. and C.B. contributed equally to this work.

  • Barbara Amadei,

    1. Laboratory of Viral Immunopathology, Division of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Italy
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  • Paola Fisicaro,

    1. Laboratory of Viral Immunopathology, Division of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Italy
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  • Simona Cerioni,

    1. Laboratory of Viral Immunopathology, Division of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Italy
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  • Maria Antonietta Valli,

    1. Laboratory of Viral Immunopathology, Division of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Italy
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  • Gabriele Missale,

    1. Laboratory of Viral Immunopathology, Division of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Italy
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  • Carlo Ferrari

    Corresponding author
    1. Laboratory of Viral Immunopathology, Division of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Italy
    • Laboratorio Immunopatologia Virale, Division of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Via Gramsci 14, 43100 Parma, Italy
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    • fax: (39) 0521 988706


  • Conflicts of interest: Nothing to report.

Abstract

To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infection spontaneously. Acute-phase CD4 responses were efficient in self-limited infections but undetectable in the coinfected patient with HBV persistence. CD8 responses were multispecific irrespective of the outcome of infection, but the CD8 repertoire associated with HBV persistence lacked the most dominant specificities detectable in self-limited infections. In conclusion, insufficient CD4 help and defective CD8 repertoire may play a role at the early stages of infection in influencing HBV persistence. (HEPATOLOGY 2005.)

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