S.U. and C.B. contributed equally to this work.
Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection†
Article first published online: 22 FEB 2005
Copyright © 2005 American Association for the Study of Liver Diseases
Volume 41, Issue 4, pages 826–831, April 2005
How to Cite
Urbani, S., Boni, C., Amadei, B., Fisicaro, P., Cerioni, S., Valli, M. A., Missale, G. and Ferrari, C. (2005), Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection. Hepatology, 41: 826–831. doi: 10.1002/hep.20614
Conflicts of interest: Nothing to report.
- Issue published online: 23 MAR 2005
- Article first published online: 22 FEB 2005
- Manuscript Accepted: 4 JAN 2005
- Manuscript Received: 22 OCT 2004
- FIRB (Fondo per gli investimenti della ricerca di base; Ministry of Education, University and Research, Italy). Grant Number: RBNE013PMJ_006
To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infection spontaneously. Acute-phase CD4 responses were efficient in self-limited infections but undetectable in the coinfected patient with HBV persistence. CD8 responses were multispecific irrespective of the outcome of infection, but the CD8 repertoire associated with HBV persistence lacked the most dominant specificities detectable in self-limited infections. In conclusion, insufficient CD4 help and defective CD8 repertoire may play a role at the early stages of infection in influencing HBV persistence. (HEPATOLOGY 2005.)