• 1
    Nathanson MH, Boyer JL. Mechanisms and regulation of bile secretion. HEPATOLOGY 1991; 14: 551566.
  • 2
    Alpini G, Phillips JO, LaRusso NF. The biology of the biliary epithelia. In: AriasI, BoyerJ, FaustoN, JakobyW, SchachterD & ShafritzDA, eds. The Liver; Biology & Pathobiology, 3E. New York, NY: Raven Press, 1994: 623653.
  • 3
    Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 2003; 83: 633671.
  • 4
    Hofmann AF. Current concepts of biliary secretion. Dig Dis Sci 1989; 34 (Suppl 12): 16S20S.
  • 5
    Gurantz D, Hofmann AF. Influence of bile acid structure on bile flow and biliary lipid secretion in the hamster. Am J Physiol 1984; 247: G736G748.
  • 6
    Alpini G, Glaser SS, Rodgers R, Phinizy JL, Robertson WE, Lasater J, et al. Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes. Gastroenterology 1997; 113: 17341740.
  • 7
    Masyuk AI, Gong AY, Kip S, Burke MJ, LaRusso NF. Perfused rat intrahepatic bile ducts secrete and absorb water, solute, and ions. Gastroenterology 2000; 119: 16721680.
  • 8
    Bradbury NA, Bridges RJ. Role of membrane trafficking in plasma membrane solute transport. Am J Physiol 1994; 267: C1C24.
  • 9
    Nielsen S, Smith BL, Christensen EI, Agre P. Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc Natl Acad Sci 1993; 90: 72757259.
  • 10
    Marinelli RA, Tietz PS, Pham LD, Rueckert L, Agre P, LaRusso NF. Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes. Am J Physiol 1999; 276: G280G286.
  • 11
    Tietz PS, Marinelli RA, Chen XM, Huang B, Cohn J, Kole J, et al. Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes. J Biol Chem 2003; 278: 2041320419.
  • 12
    Alpini G, Lenzi R, Sarkozi L, Tavoloni N. Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules. J Clin Invest 1988; 81: 569578.
  • 13
    Alpini G, Ulrich CD 2nd, Phillips JO, Pham LD, Miller LJ, LaRusso NF. Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation. Am J Physiol 1994; 266: G922G928.
  • 14
    Ishii M, Vroman B, LaRusso NF. Isolation and morphological characterization of bile duct epithelial cells from normal rat liver. Gastroenterology 1989; 97: 12361247.
  • 15
    Vaughn WK, Neal RA, Anderson AJ. Computer estimation of the parameters of the sigmoidal kinetic model. Comput Biol Med 1976; 6: 17.
  • 16
    Marinelli RA, Pham L, Agre P, LaRusso NF. Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membrane. Evidence for a secretin-induced vesicular translocation of aquaporin-1. J Biol Chem 1997; 272: 1298412988.
  • 17
    Alpini G, Glaser S, Alvaro D, Ueno Y, Marzioni M, Francis H, et al. Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats. Gastroenterology 2002; 123: 12261237.
  • 18
    Crawford JM. Role of vesicle-mediated transport pathways in hepatocellular bile secretion. Semin Liver Dis 1996; 16: 169189.
  • 19
    Crawford JM, Berken CA, Gollan JL. Role of the hepatocyte microtubular system in the excretion of bile salts and biliary lipid: implications for intracellular vesicular transport. J Lipid Res 1988; 29: 144156.
  • 20
    Yamamoto T, Sasaki S, Fushimi K, Ishibashi K, Yaoita E, Kawasaki K, et al. Vasopressin increases AQP-CD water channel in apical membrane of collecting duct cells in Brattleboro rats. Am J Physiol 1995; 268: C1546C1551.
  • 21
    Nielsen S, Smith BL, Christensen EI, Knepper MA, Agre P. CHIP28 water channels are localized in constitutively water-permeable segments of the nephron. J Cell Biol 1993; 120: 371383.
  • 22
    Reymann A, Braun W, Drobik C, Woermann C. Stimulation of bile acid active transport related to increased mucosal cyclic AMP content in rat ileum in vitro. Biochim Biophys Acta 1989; 1011: 158164.
  • 23
    Hofmann AFY, AZ, Schteingart CD, Bolder U, Ton-Nu Ht, Hagey LR: The cholehepatic circulation of organic anions: a decade of progress. In: AlavaoD, Strazzabosco, M and Benedetti, A, eds. Vanishing Bile Duct Syndrome—Pathophysiology and Treatment. Dordrecht: Kluwer Academic Press, 1997: 90103.
  • 24
    Alpini G, Lenzi R, Zhai WR, Slott PA, Liu MH, Sarkozi L, Tavoloni N. Bile secretory function of intrahepatic biliary epithelium in the rat. Am J Physiol 1989; 257: G124G133.
  • 25
    Dawson PA, Haywood J, Craddock AL, Wilson M, Tietjen M, Kluckman K, et al. Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J Biol Chem 2003; 278: 3392033927.
  • 26
    Gurantz D, Schteingart CD, Hagey LR, Steinbach JH, Grotmol T, Hofmann AF. Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids. HEPATOLOGY 1991; 13: 540550.
  • 27
    Alpini G, Glaser S, Robertson W, Phinizy JL, Rodgers R, Caligiuri A, LeSage G. Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes. Am J Physiol 1997; 273: G518G529.
  • 28
    Baiocchi L, Alpini G, Glaser S, Angelico M, Alvaro D, Francis H, et al. Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats. J Hepatol 2003; 38: 136147.
  • 29
    Alpini G, Glaser SS, Ueno Y, Pham L, Podila PV, Caligiuri A, et al. Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. Am J Physiol 1998; 274: G767G775.