Liver Failure and Liver Disease

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Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling†

  1. Suk Woo Nam1,2,
  2. Jik Young Park1,2,
  3. Adaikalavan Ramasamy3,
  4. Shirish Shevade3,
  5. Amirul Islam3,
  6. Philip M. Long3,
  7. Cheol Keun Park4,
  8. Soo Eun Park1,2,
  9. Su Young Kim1,2,
  10. Sug Hyung Lee1,2,
  11. Won Sang Park1,2,
  12. Nam Jin Yoo1,2,
  13. Edison T. Liu3,
  14. Lance D. Miller Ph.D.3,‡,*,
  15. Jung Young Lee M.D., Ph.D.1,2,§,*

Article first published online: 20 SEP 2005

DOI: 10.1002/hep.20878

Issue

Hepatology

Hepatology

Volume 42, Issue 4, pages 809–818, October 2005

Additional Information

How to Cite

Nam, S. W., Park, J. Y., Ramasamy, A., Shevade, S., Islam, A., Long, P. M., Park, C. K., Park, S. E., Kim, S. Y., Lee, S. H., Park, W. S., Yoo, N. J., Liu, E. T., Miller, L. D. and Lee, J. Y. (2005), Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling. Hepatology, 42: 809–818. doi: 10.1002/hep.20878

Author Information

  1. 1

    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea

  2. 2

    Microdissection Genomics Research Center, College of Medicine, The Catholic University of Korea, Seoul, South Korea

  3. 3

    Genome Institute of Singapore, Singapore

  4. 4

    Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

  1. ‡

    fax: (65) 6478–9060

  2. §

    fax: (82) 2–537–6586

*Department of Pathology, College of Medicine, The Catholic University of Korea, #505 Banpodong, Seocho-gu, Seoul, South Korea, 137–701

  1. †

    Potential conflict of interest: Nothing to report.

Publication History

  1. Issue published online: 20 SEP 2005
  2. Article first published online: 20 SEP 2005
  3. Manuscript Accepted: 15 JUL 2005
  4. Manuscript Received: 3 MAY 2005

Funded by

  • Korea Science & Engineering Foundation (KOSEF) through the Cell Death Disease Research Center at The Catholic University of Korea. Grant Number: R13-2002-005-01004-0
  • 21C Frontier Foundation Human Genome Project from Ministry of Science and Technology of Korea. Grant Number: F-1-1-02

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References

  • 1
    Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002; 31: 339–346.
  • 2
    Pang A, Ng IO, Fan ST, Kwong YL. Clinicopathologic significance of genetic alterations in hepatocellular carcinoma. Cancer Genet Cytogenet 2003; 146: 8–15.
  • 3
    de La CA, Romagnolo B, Billuart P, Renard CA, Buendia MA, Soubrane O, et al. Somatic mutations of the betacatenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci U S A 1998; 95: 8847–8851.
  • 4
    Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000; 24: 245–250.
  • 5
    Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Okazaki N, Takayasu K, et al. Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 1990; 336: 1150–1153.
  • 6
    Theise ND, Park YN, Kojiro M. Dysplastic nodules and hepatocarcinogenesis. Clin Liver Dis 2002; 6: 497–512.
  • 7
    Terminology of nodular hepatocellular lesions. International Working Party. HEPATOLOGY 1995; 22: 983–993.
  • 8
    Tornillo L, Carafa V, Sauter G, Moch H, Minola E, Gambacorta M, et al. Chromosomal alterations in hepatocellular nodules by comparative genomic hybridization: high-grade dysplastic nodules represent early stages of hepatocellular carcinoma. Lab Invest 2002; 82: 547–553.
  • 9
    Sakamoto M, Hirohashi S, Shimosato Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 1991; 22: 172–178.
  • 10
    Kanai T, Hirohashi S, Upton MP, Noguchi M, Kishi K, Makuuchi M, et al. Pathology of small hepatocellular carcinoma. A proposal for a new gross classification. Cancer 1987; 60: 810–819.
    Direct Link:
  • 11
    Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Yamamoto J, Shimada K, et al. Early hepatocellular carcinoma as an entity with a high rate of surgical cure. HEPATOLOGY 1998; 28: 1241–1246.
  • 12
    Kojiro M. Premalignant lesions of hepatocellular carcinoma: pathologic viewpoint. J Hepatobiliary Pancreat Surg 2000; 7: 535–541.
  • 13
    Theise ND, Park YN, Kojiro M. Dysplastic nodules and hepatocarcinogenesis. Clin Liver Dis 2002; 6: 497–512.
  • 14
    Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7: 462–503.
    Direct Link:
  • 15
    Ferrell LD, Crawford JM, Dhillon AP, Scheuer PJ, Nakanuma Y. Proposal for standardized criteria for the diagnosis of benign, borderline, and malignant hepatocellular lesions arising in chronic advanced liver disease. Am J Surg Pathol 1993; 17: 1113–1123.
  • 16
    Kenmochi K, Sugihara S, Kojiro M. Relationship of histologic grade of hepatocellular carcinoma (HCC) to tumor size, and demonstration of tumor cells of multiple different grades in single small HCC. Liver 1987; 7: 18–26.
  • 17
    Chen X, Cheung ST, So S, Fan ST, Barry C, Higgins J, et al. Gene expression patterns in human liver cancers. Mol Biol Cell 2002; 13: 1929–1939.
  • 18
    Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, et al. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Proc Natl Acad Sci U S A 2001; 98: 15089–15094.
  • 19
    Okabe H, Satoh S, Kato T, Kitahara O, Yanagawa R, Yamaoka Y, et al. Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res 2001; 61: 2129–2137.
  • 20
    Lee JS, Chu IS, Heo J, Calvisi DF, Sun Z, Roskams T, et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. HEPATOLOGY 2004; 40: 667–676.
  • 21
    Eisen MB, Brown PO. DNA arrays for analysis of gene expression. Methods Enzymol 1999; 303: 179–205.
  • 22
    DeRisi JL, Iyer VR, Brown PO. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 1997; 278: 680–686.
  • 23
    Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 1998; 95: 14863–14868.
  • 24
    Brown MP, Grundy WN, Lin D, Cristianini N, Sugnet CW, Furey TS, et al. Knowledge-based analysis of microarray gene expression data by using support vector machines. Proc Natl Acad Sci U S A 2000; 97: 262–267.
  • 25
    Furey TS, Cristianini N, Duffy N, Bednarski DW, Schummer M, Haussler D. Support vector machine classification and validation of cancer tissue samples using microarray expression data. Bioinformatics 2000; 16: 906–914.
  • 26
    Ramaswamy S, Tamayo P, Rifkin R, Mukherjee S, Yeang CH, Angelo M, et al. Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A 2001; 98: 15149–15154.
  • 27
    Whitfield ML, Sherlock G, Saldanha AJ, Murray JI, Ball CA, Alexander KE, et al. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell 2002; 13: 1977–2000.
  • 28
    Troyanskaya O, Cantor M, Sherlock G, Brown P, Hastie T, Tibshirani R, et al. Missing value estimation methods for DNA microarrays. Bioinformatics 2001; 17: 520–525.
  • 29
    Kim I, Kang HC, Park J. Microarray application in cancer research. Cancer Research and Treatment 2004; 36: 207–213.
  • 30
    Kojiro M. Pathology of early hepatocellular carcinoma: progression from early to advanced. Hepatogastroenterology 1998; 45(Suppl 3): 1203–1205.
  • 31
    Kojiro M, Yano H, Nakashima O. Pathology of early hepatocellular carcinoma: progression from early to advanced. Semin Surg Oncol 1996; 12: 197–203.
    Direct Link:
  • 32
    Huang SL, Shyu RY, Yeh MY, Jiang SY. The retinoid-inducible gene I: effect on apoptosis and mitogen-activated kinase signal pathways. Anticancer Res 2002; 22: 799–804.
  • 33
    Casanova B, de la Fuente MT, Garcia-Gila M, Sanz L, Silva A, Garcia-Marco JA, Garcia-Pardo A. The class II tumor-suppressor gene RARRES3 is expressed in B cell lymphocytic leukemias and down-regulated with disease progression. Leukemia 2001; 15: 1521–1526.
  • 34
    Shyu RY, Jiang SY, Chou JM, Shih YL, Lee MS, Yu JC, et al. RARRES3 expression positively correlated to tumour differentiation in tissues of colorectal adenocarcinoma. Br J Cancer 2003; 89: 146–151.
  • 35
    Chen X, Cheung ST, So S, Fan ST, Barry C, Higgins J, et al. Gene expression patterns in human liver cancers. Mol Biol Cell 2002; 13: 1929–1939.
  • 36
    Chuma M, Sakamoto M, Yamazaki K, Ohta T, Ohki M, Asaka M, et al. Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma. HEPATOLOGY 2003; 37: 198–207.
    Direct Link:
  • 37
    Lee JS, Chu IS, Heo J, Calvisi DF, Sun Z, Roskams T, et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. HEPATOLOGY 2004; 40: 667–676.
    Direct Link:
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