Liver Failure and Liver Disease

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Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling†

  1. Suk Woo Nam1,2,
  2. Jik Young Park1,2,
  3. Adaikalavan Ramasamy3,
  4. Shirish Shevade3,
  5. Amirul Islam3,
  6. Philip M. Long3,
  7. Cheol Keun Park4,
  8. Soo Eun Park1,2,
  9. Su Young Kim1,2,
  10. Sug Hyung Lee1,2,
  11. Won Sang Park1,2,
  12. Nam Jin Yoo1,2,
  13. Edison T. Liu3,
  14. Lance D. Miller Ph.D.3,‡,*,
  15. Jung Young Lee M.D., Ph.D.1,2,§,*

Article first published online: 20 SEP 2005

DOI: 10.1002/hep.20878

Issue

Hepatology

Hepatology

Volume 42, Issue 4, pages 809–818, October 2005

Additional Information

How to Cite

Nam, S. W., Park, J. Y., Ramasamy, A., Shevade, S., Islam, A., Long, P. M., Park, C. K., Park, S. E., Kim, S. Y., Lee, S. H., Park, W. S., Yoo, N. J., Liu, E. T., Miller, L. D. and Lee, J. Y. (2005), Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling. Hepatology, 42: 809–818. doi: 10.1002/hep.20878

Author Information

  1. 1

    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea

  2. 2

    Microdissection Genomics Research Center, College of Medicine, The Catholic University of Korea, Seoul, South Korea

  3. 3

    Genome Institute of Singapore, Singapore

  4. 4

    Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

  1. ‡

    fax: (65) 6478–9060

  2. §

    fax: (82) 2–537–6586

*Department of Pathology, College of Medicine, The Catholic University of Korea, #505 Banpodong, Seocho-gu, Seoul, South Korea, 137–701

  1. †

    Potential conflict of interest: Nothing to report.

Publication History

  1. Issue published online: 20 SEP 2005
  2. Article first published online: 20 SEP 2005
  3. Manuscript Accepted: 15 JUL 2005
  4. Manuscript Received: 3 MAY 2005

Funded by

  • Korea Science & Engineering Foundation (KOSEF) through the Cell Death Disease Research Center at The Catholic University of Korea. Grant Number: R13-2002-005-01004-0
  • 21C Frontier Foundation Human Genome Project from Ministry of Science and Technology of Korea. Grant Number: F-1-1-02

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This article includes Supplementary material available at http://www.interscience.wiley.com/jpages/0270-9139/suppmat

FilenameFormatSizeDescription
jws-hep.20878.fig1.tif298K. Comparison of expression profiling of nontumorigenic tissues, dysplastic nodules, and HCCs. Hundred outlier genes for each grade (LGDN, HGDN, G1-3 HCCs) were selected by combination of OVA T-test and ANOVA (see Materials and Methods), and the corresponding outliers were also selected from nontumorigenic tissues with cirrhosis (designated as "NL"), then combined and analyze the expression pattern of all outlier genes. The heat-map of hierarchical clustering analysis (a) and its dendrogram (b) show that NL arrays located very close together with dysplastic nodule cluster, and formed subscluter within dysplastic nodule cluster, suggesting molecular nature of dysplastic nodule is more like NL, but may have distinct signature with dysplastic nodule.
jws-hep.20878.tbl1-.doc236K Supplementary Table 1.Clinical data and diagnostic details on experimental samples. Supplementary Table 2.The list of 120 early stage genes for discriminating among early-stage samples * Any probes selected twice in a classification problem are marked with an asterisk. Supplementary Table 3.The list of 120 late stage genes for discriminating among late-stage samples * Any probes selected twice in a classification problem are marked with an asterisk.

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