Liver Biology and Pathobiology
Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury†
Article first published online: 25 OCT 2005
Copyright © 2005 American Association for the Study of Liver Diseases
Volume 42, Issue 5, pages 1137–1147, November 2005
How to Cite
Powell, C. L., Kosyk, O., Bradford, B. U., Parker, J. S., Lobenhofer, E. K., Denda, A., Uematsu, F., Nakae, D. and Rusyn, I. (2005), Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury. Hepatology, 42: 1137–1147. doi: 10.1002/hep.20910
Potential conflict of interest: Nothing to report.
- Issue published online: 25 OCT 2005
- Article first published online: 25 OCT 2005
- Manuscript Accepted: 23 AUG 2005
- Manuscript Received: 9 FEB 2005
- National Institutes of Health (NIH). Grant Numbers: ES11391, ES11660, ES10126, CA52806, CA82506
- Ministry of Health, Labor, and Welfare of Japan. Grant Numbers: 14-9, 14-11
- Transition to Independent Position award from the National Institute of Environmental Health Sciences (NIEHS). Grant Number: ES11660
- NIEHS Training Grant from NIH. Grant Number: T32-ES07126
Supplementary material for this article can be found on the H EPATOLOGY website ( http://www.interscience.wiley.com/jpages/0270-9139/suppmat ).
|jws-hep.20910.fig1.tif||5232K||Unsupervised hierarchical clustering of 15,866 genes in liver distinguishes between choline sufficient (CS) and choline deficient (CD) treated rats. Hierarchical clustering analysis was conducted on control choline sufficient (CS) or choline deficient (CD) liver samples collected between 4 and 80 weeks. Tumor (T) samples were collected at 80 weeks from CD-treated rats. The dendrogram shows that the samples clustered into two groups according to treatment. The color of each gene is proportional to the mean expression level (in log 2units, see color bar) of the gene across the entire set of samples (red - median, black - no change, and green - below median value).|
|jws-hep.20910.fig2.tif||2733K||KEGG-annotated pathways that are significantly enriched in CD rats. Two significant gene lists were generated using intrinsic gene identifier (white bar) or SAM (grey bar) and the number of genes (as identified by each procedure) for a given KEGG pathway is shown in comparison to a total number of genes in that representative pathway (black bar).|
|jws-hep.20910.tbl1.doc||707K||Supporting Information file jws-hep.20910.tbl1.doc|
|jws-hep.20910.tbl2.doc||536K||Supporting Information file jws-hep.20910.tbl2.doc|
|jws-hep.20910.tbl3.doc||456K||Supporting Information file jws-hep.20910.tbl3.doc|
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