• 1
    Chiang JY. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr Rev 2002; 23: 443463.
  • 2
    Russell DW, Setchell KD. Bile acid biosynthesis. Biochemistry 1992; 31: 47374749.
  • 3
    Chiang JY. Regulation of bile acid synthesis. Front Biosci 1998; 3: d176d193.
  • 4
    Li T, Chiang JY. Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 α-hydroxylase gene transcription. Am J Physiol Gastrointest Liver Physiol 2005; 288: G74G84.
  • 5
    Stroup D, Chiang JY. HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7α-hydroxylase gene (CYP7A1). J Lipid Res 2000; 41: 111.
  • 6
    Hayhurst GP, Lee YH, Lambert G, Ward JM, Gonzalez FJ. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 2001; 21: 13931403.
  • 7
    Chiang JY. Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms. J Hepatol 2004; 40: 539551.
  • 8
    Xu G, Salen G, Shefer S, Tint GS, Nguyen LB, Parker TT, et al. Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion. J Lipid Res 1998; 39: 16081615.
  • 9
    Horton JD, Cuthbert JA, Spady DK. Regulation of hepatic 7α-hydroxylase expression and response to dietary cholesterol in the rat and hamster. J Biol Chem 1995; 270: 53815387.
  • 10
    Rudel L, Deckelman C, Wilson M, Scobey M, Anderson R. Dietary cholesterol and downregulation of cholesterol 7α-hydroxylase and cholesterol absorption in African green monkeys. J Clin Invest 1994; 93: 24632472.
  • 11
    Agellon LB, Drover VA, Cheema SK, Gbaguidi GF, Walsh A. Dietary cholesterol fails to stimulate the human cholesterol 7α-hydroxylase gene (CYP7A1) in transgenic mice. J Biol Chem 2002; 277: 2013120134.
  • 12
    Chiang JY, Kimmel R, Stroup D. Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα). Gene 2001; 262: 257265.
  • 13
    Goodwin B, Watson MA, Kim H, Miao J, Kemper JK, Kliewer SA. Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. Mol Endocrinol 2003; 17: 386394.
  • 14
    De Fabiani E, Mitro N, Gilardi F, Caruso D, Galli G, Crestani M. Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle. J Biol Chem 2003; 278: 3912439132.
  • 15
    Shin DJ, Campos JA, Gil G, Osborne TF. PGC-1α activates CYP7A1 and bile acid biosynthesis. J Biol Chem 2003; 278: 5004750052.
  • 16
    Lewis DS, Oren S, Wang X, Moyer ML, Beitz DC, Knight TJ, et al. Developmental changes in cholesterol 7α- and 27-hydroxylases in the piglet. J Anim Sci 2000; 78: 943951.
  • 17
    Bjorkhem I, Akerlund JE. Studies on the link between HMG-CoA reductase and cholesterol 7α-hydroxylase in rat liver. J Lipid Res 1988; 29: 136143.
  • 18
    Noshiro M, Nishimoto M, Okuda K. Rat liver cholesterol 7α-hydroxylase: pretranslational regulation for circadian rhythm. J Biol Chem 1990; 265: 1003610041.
  • 19
    Nguyen LB, Shefer S, Salen G, Ness G, Tanaka RD, Packin V, et al. Purification of cholesterol 7α-hydroxylase from human and rat liver and production of inhibiting polyclonal antibodies. J Biol Chem 1990; 265: 45414546.
  • 20
    Maurer RA. Both isoforms of the cAMP-dependent protein kinase catalytic subunit can activate transcription of the prolactin gene. J Biol Chem 1989; 264: 68706873.
  • 21
    Park YY, Kim HJ, Kim JY, Kim MY, Song KH, Cheol Park K, et al. Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1. Mol Endocrinol 2004; 18: 10821095.
  • 22
    Wang DP, Stroup D, Marrapodi M, Crestani M, Galli G, Chiang JY. Transcriptional regulation of the human cholesterol 7α-hydroxylase gene (CYP7A) in HepG2 cells. J Lipid Res 1996; 37: 18311841.
  • 23
    Chakravarty K, Wu SY, Chiang CM, Samols D, Hanson RW. SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver. J Biol Chem 2004; 279: 1538515395.
  • 24
    Crestani M, Sadeghpour A, Stroup D, Galli G, Chiang JY. Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors. J Lipid Res 1998; 39: 21922200.
  • 25
    Viollet B, Kahn A, Raymondjean M. Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4. Mol Cell Biol 1997; 17: 42084219.
  • 26
    Hong YH, Varanasi US, Yang W, Leff T. AMP-activated protein kinase regulates HNF4α transcriptional activity by inhibiting dimer formation and decreasing protein stability. J Biol Chem 2003; 278: 2749527501.
  • 27
    Ktistaki E, Ktistakis NT, Papadogeorgaki E, Talianidis I. Recruitment of hepatocyte nuclear factor 4 into specific intranuclear compartments depends on tyrosine phosphorylation that affects its DNA-binding and transactivation potential. Proc Natl Acad Sci U S A 1995; 92: 98769880.
  • 28
    Chiang JY. Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors. Am J Physiol Gastrointest Liver Physiol 2003; 284: G349G356.
  • 29
    Hylemon PB, Gurley EC, Stravitz RT, Litz JS, Pandak WM, Chiang JY, et al. Hormonal regulation of cholesterol 7α-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures. J Biol Chem 1992; 267: 1686616871.
  • 30
    Savendahl L, Underwood LE. Fasting increases serum total cholesterol, LDL cholesterol and apolipoprotein B in healthy, nonobese humans. J Nutr 1999; 129: 20052008.
  • 31
    Stayrook KR, Bramlett KS, Savkur RS, Ficorilli J, Cook T, Christe ME, et al. Regulation of carbohydrate metabolism by the farnesoid X receptor. Endocrinology 2005; 146: 984991.
  • 32
    Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 2001; 413: 131138.