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Liver Failure and Liver Disease
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Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study†‡
Article first published online: 29 NOV 2005
DOI: 10.1002/hep.20948
Copyright © 2005 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Larson, A. M., Polson, J., Fontana, R. J., Davern, T. J., Lalani, E., Hynan, L. S., Reisch, J. S., Schiødt, F. V., Ostapowicz, G., Shakil, A. O. and Lee, W. M. (2005), Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study. Hepatology, 42: 1364–1372. doi: 10.1002/hep.20948
- †
See Editorial on Page 1252.
- ‡
Potential conflict of interest: Nothing to report.
Publication History
- Issue published online: 29 NOV 2005
- Article first published online: 29 NOV 2005
- Manuscript Accepted: 12 SEP 2005
- Manuscript Received: 24 JUN 2005
Funded by
- NIDDK. Grant Number: R-01-DK58639
- Stephen B. Tips Fund at Northwestern University
- FDA. Grant Number: FD-R-001661
- NIH. Grant Numbers: R-O3 DK52827, R-01 DK58369
- Stephen B. Tips Fund of Northwestern Medical Foundation
- Jeanne Roberts Fund of the Southwestern Medical Foundation
- AASLD/Schering Research Fellowship
- Abstract
- Article
- References
- Cited By
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- 1, , , , Acetaminophen overdose in the Military Health System, Pharmacoepidemiology and Drug Safety, 2012, 21, 4Direct Link:
- 2, , , , , Activation of autophagy protects against acetaminophen-induced hepatotoxicity, Hepatology, 2012, 55, 1Direct Link:
- 3, , , , , , , Antioxidant Properties ofTaraxacum officinaleLeaf Extract Are Involved in the Protective Effect Against Hepatoxicity Induced by Acetaminophen in Mice, Journal of Medicinal Food, 2012, 120316094852001
- 4, , , , , , , Background incidence of liver chemistry abnormalities in pediatric clinical trials for conditions with and without underlying liver disease, Regulatory Toxicology and Pharmacology, 2012, 62, 2, 329
- 5, , , , , , , , , Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure, Liver Transplantation, 2012, 18, 4Direct Link:
- You have free access to this content6, , , , Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics, Journal of Applied Toxicology, 2012, 32, 7Direct Link:
- 7
- 8, , , , , , , Echinomycin Decreases Induction of Vascular Endothelial Growth Factor and Hepatocyte Regeneration in Acetaminophen Toxicity in Mice, Basic & Clinical Pharmacology & Toxicology, 2012, 110, 4Direct Link:
- 9, , , , , , , , , , , , , , Etiologies and Outcomes of Acute Liver Failure in Germany, Clinical Gastroenterology and Hepatology, 2012,
- 10, , , , , , , Hesperidin alleviates acetaminophen induced toxicity in wistar rats by abrogation of oxidative stress, apoptosis and inflammation, Toxicology Letters, 2012, 208, 2, 149
- 11, , Is the Patient a Candidate for Liver Transplantation?, Clinics in Liver Disease, 2012, 16, 2, 435
- 12, Liver: Determining prognosis in acute liver failure, Nature Reviews Gastroenterology & Hepatology, 2012, 9, 4, 192
- 13
- 14, , , , , , , Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice, Environmental Toxicology and Pharmacology, 2012, 34, 2, 127
- 15, , Novel nanostructure-based electrochemical sensor for simultaneous determination of dopamine and acetaminophen, Materials Science and Engineering: C, 2012, 32, 2, 375
- 16, , , Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity, Drug Metabolism Reviews, 2012, 44, 1, 88
- 17, , , , Polypharmacy and the Role of Physical Medicine and Rehabilitation, PM&R, 2012, 4, 3, 198
- 18, , , Prescription Acetaminophen Ingestions Associated with Hepatic Injury and Death, Journal of Community Health, 2012,
- 19, , Prescription-acquired acetaminophen use and potential overuse patterns: 2001–2008, Pharmacoepidemiology and Drug Safety, 2012, 21, 2Direct Link:
- 20, Recent developments in acute liver failure, Best Practice & Research Clinical Gastroenterology, 2012, 26, 1, 3
- You have free access to this content21, , , , , , Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity, British Journal of Clinical Pharmacology, 2012, 73, 2Direct Link:
- 22, , , , , , , Systematic review: extracorporeal bio-artificial liver-support system for liver failure, Hepatology International, 2012,
- 23, , , , , , The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation, Journal of Clinical Investigation, 2012, 122, 4, 1574
- 24, , , , , , , , The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients, Clinical Toxicology, 2012, 50, 1, 27
- 25, , , , , , , The sequential organ failure assessment (SOFA) score is an effective triage marker following staggered paracetamol (acetaminophen) overdose, Alimentary Pharmacology & Therapeutics, 2012, 35, 12Direct Link:
- 26, , , , , , , The sequential organ failure assessment (SOFA) score is prognostically superior to the model for end-stage liver disease (MELD) and MELD variants following paracetamol (acetaminophen) overdose, Alimentary Pharmacology & Therapeutics, 2012, 35, 6Direct Link:
- 27, , , , , , Tournefortia sarmentosaextract attenuates acetaminophen-induced hepatotoxicity, Pharmaceutical Biology, 2012, 50, 3, 291
- 28, , , Trends in Hepatic Injury Associated with Unintentional Overdose of Paracetamol (Acetaminophen) in Products with and without Opioid, Drug Safety, 2012, 35, 2, 149
- 29
- 30
- 31
- 32
- 33
- 34
- 35
- 36, , , , , , , , , , 3,5,5-Trimethyl-Hexanoyl-Ferrocene Diet Protects Mice from Moderate Transient Acetaminophen-Induced Hepatotoxicity, Toxicological Sciences, 2011, 124, 2, 348
- 37, , , , , , , Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice, Journal of Clinical Investigation, 2011, 121, 11, 4446
- 38, , , , , , , , , Acute kidney injury in patients admitted to a liver intensive therapy unit with paracetamol-induced hepatotoxicity, Nephrology Dialysis Transplantation, 2011, 26, 11, 3501
- 39, , , , , , , , Acute liver failure in Scotland between 1992 and 2009; incidence, aetiology and outcome, QJM, 2011, 104, 11, 945
- 40, , Adult liver transplantation in the USA, Current Opinion in Gastroenterology, 2011, 27, 3, 240
- 41, An Overview of Drug-induced Liver Injury, The Journal for Nurse Practitioners, 2011, 7, 10, 819
- 42, , , , , , , Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity, Toxicological Sciences, 2011, 122, 2, 598
- 43, , , , , Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States, Pharmacoepidemiology and Drug Safety, 2011, 20, 8Direct Link:
- 44, , , , , , , , , , , , , , Circulating microRNAs as potential markers of human drug-induced liver injury, Hepatology, 2011, 54, 5Direct Link:
- 45, , , , Clinical course of repeated supratherapeutic ingestion of acetaminophen, Clinical Toxicology, 2011, 49, 2, 108
- 46, , Conservative Treatment for Neck Pain: Medications, Physical Therapy, and Exercise, Physical Medicine and Rehabilitation Clinics of North America, 2011, 22, 3, 503
- 47, , , , , Determination of quinacrine dihydrochloride dihydrate stability and characterization of its degradants, Journal of Pharmaceutical Sciences, 2011, 100, 8Direct Link:
- 48, , , , , , , , Developing Consumer-Centered, Nonprescription Drug Labeling, American Journal of Preventive Medicine, 2011, 40, 6, 593
- 49, , , Development of an in vitro liver toxicity prediction model based on longer term primary rat hepatocyte culture, Toxicology Letters, 2011, 206, 2, 189
- 50, , , Emergency Department Visits for Overdoses of Acetaminophen-Containing Products, American Journal of Preventive Medicine, 2011, 40, 6, 585
- 51, , Epidemiology of liver failure, Clinics and Research in Hepatology and Gastroenterology, 2011, 35, 10, 610
- 52, Geriatric Pharmacotherapy Updates, The American Journal of Geriatric Pharmacotherapy, 2011, 9, 3, 204
- 53, , , , , , , , , Hepatoprotective activity of a vinylic telluride against acute exposure to acetaminophen, European Journal of Pharmacology, 2011, 661, 1-3, 92
- 54, , , Hepatoprotective activity of the total flavonoids from Rosa laevigata Michx fruit in mice treated by paracetamol, Food Chemistry, 2011, 125, 2, 719
- 55, , , Highly specific, sensitive and rapid enzyme immunoassays for the measurement of acetaminophen in serum, Analytical and Bioanalytical Chemistry, 2011, 401, 7, 2195
- 56, , , Hypothermia and Protection from Acetaminophen-Induced Liver Injury, Therapeutic Hypothermia and Temperature Management, 2011, 1, 1, 57
- 57, , , , , , , Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity, Chemico-Biological Interactions, 2011, 189, 3, 222
- 58, , Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells, Phytomedicine, 2011, 18, 7, 592
- 59, , , , , , , , , Measurement of adherence to clinical practice guidelines for opioid therapy for chronic pain, Translational Behavioral Medicine, 2011, 2, 1, 57
- 60, , Mechanisms of drug-induced liver injury: from bedside to bench, Nature Reviews Gastroenterology & Hepatology, 2011, 8, 4, 202
- 61, , , , , Misunderstanding and Potential Unintended Misuse of Acetaminophen Among Adolescents and Young Adults, Journal of Health Communication, 2011, 16, sup3, 256
- 62, , , , , , , , Misuse of acetaminophen in the management of dental pain, Pharmacoepidemiology and Drug Safety, 2011, 20, 9Direct Link:
- 63, , , , , Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation, Toxicology and Applied Pharmacology, 2011, 257, 3, 449
- 64, , , , N-acetylcysteine-induced headache in hospitalized patients with acute acetaminophen overdose, Fundamental & Clinical Pharmacology, 2011, 25, 3Direct Link:
- 65, , , , , Opioid-Paracetamol Prescription Patterns and Liver Dysfunction, Drug Safety, 2011, 34, 11, 1079
- 66, , , , , , Overdose pattern and outcome in paracetamol-induced acute severe hepatotoxicity, British Journal of Clinical Pharmacology, 2011, 71, 2Direct Link:
- 67, , , , , Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase, Trends in Molecular Medicine, 2011, 17, 7, 395
- 68, , , , , , , , , , , , , Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a prospective case series, BMC Gastroenterology, 2011, 11, 1, 80
- 69, , , , Paracetamol overdose: the liver unit perspective, Irish Journal of Medical Science, 2011,
- 70, Perioperative Intravenous Acetaminophen and NSAIDs, Pain Medicine, 2011, 12, 6Direct Link:
- 71, , , Prescription Drug Monitoring Programs and Death Rates from Drug Overdose, Pain Medicine, 2011, 12, 5Direct Link:
- 72, , , , , , , , , , , Réactualisation de la méthode française d’imputabilité des effets indésirables des médicaments, Thérapie, 2011, 66, 6, 517
- 73, , , , , , , Rhein protects against acetaminophen-induced hepatic and renal toxicity, Food and Chemical Toxicology, 2011, 49, 8, 1705
- 74, , , , , , , , , Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury, Toxicology and Applied Pharmacology, 2011, 252, 3, 289
- 75, , Running in Place: The Challenge of Prescribing Medications Today, Journal of Midwifery & Women’s Health, 2011, 56, 6Direct Link:
- 76, , , , , Secretory phospholipase A2-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2, Toxicology and Applied Pharmacology, 2011, 251, 3, 173
- 77, , , , , Simultaneous determination of N-acetyl-p-aminophenol and p-aminophenol with poly(3,4-ethylenedioxythiophene) modified glassy carbon electrode, Talanta, 2011, 85, 3, 1376
- 78, , , , , , , Steroid and Ursodesoxycholic Acid Combination Therapy in Severe Drug-Induced Liver Injury, Digestion, 2011, 84, 1, 54
- 79, , , , The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity, Toxicology and Applied Pharmacology, 2011, 251, 3, 226
- 80, , The neurological manifestations of acute liver failure, Neurochemistry International, 2011,
- 81, , , , The Outcomes of Critically Ill Patients with Combined Severe Acute Liver and Kidney Injury Secondary to Paracetamol Toxicity Requiring Renal Replacement Therapy, Renal Failure, 2011, 33, 8, 785
- 82, , , , , , The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose, Alimentary Pharmacology & Therapeutics, 2011, 34, 2Direct Link:
- 83, , Trends in emergency department visits attributable to acetaminophen overdoses in the United States: 1993–2007, Pharmacoepidemiology and Drug Safety, 2011, 20, 8Direct Link:
- 84, , , , , , Tumor necrosis factor-α affects blood–brain barrier permeability in acetaminophen-induced acute liver failure, European Journal of Gastroenterology & Hepatology, 2011, 23, 7, 552
- 85, , , , , Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure , Hepatology, 2011, 53, 2Direct Link:
- 86, , , , What can be done to reduce mortality from paracetamol overdoses? A patient interview study, QJM, 2011, 105, 1, 41
- 87
- 88
- 89
- 90, , , , , , , , , Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice, Phytomedicine, 2010, 17, 6, 475
- 91, , , , Acetaminophen induced renal injury via oxidative stress and TNF-α production: Therapeutic potential of arjunolic acid, Toxicology, 2010, 268, 1-2, 8
- 92, , , , , , , , , , Acetaminophen-NAPQI Hepatotoxicity: A Cell Line Model System Genome-Wide Association Study, Toxicological Sciences, 2010, 120, 1, 33
- 93, , , , , , , , Acute Exposure to Ozone Exacerbates Acetaminophen-Induced Liver Injury in Mice, Toxicological Sciences, 2010, 115, 1, 267
- 94
- 95
- 96, , , , , , , , Antituberculosis therapy–induced acute liver failure: Magnitude, profile, prognosis, and predictors of outcome, Hepatology, 2010, 51, 5Direct Link:
- 97, Bundle Up: It’s Painful Out There—The Case for Opioid–Acetaminophen Combinations, Clinical Pharmacology & Therapeutics, 2010, 88, 3, 292
- 98, , , Detective Work in Drug-Induced Liver Injury: Sometimes It Is All About Interviewing the Right Witness, Clinical Gastroenterology and Hepatology, 2010, 8, 7, 635
- 99, Diagnosis and management of acute liver failure, Current Opinion in Gastroenterology, 2010, 26, 3, 214
- 100, , , Drug-induced acute liver failure and gastrointestinal complications, Critical Care Medicine, 2010, 38, S175
- 101, , , Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study, Hepatology, 2010, 52, 6Direct Link:
- 102, , , , FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?, Inflammopharmacology, 2010, 18, 2, 47
- 103, , Idiosyncratic Drug-Induced Liver Injury: A Clinical Update, Current Gastroenterology Reports, 2010, 13, 1, 65
- 104, , , Iron Potentiates Acetaminophen-Induced Oxidative Stress and Mitochondrial Dysfunction in Cultured Mouse Hepatocytes, Toxicological Sciences, 2010, 118, 1, 119
- 105, , , , , , Lactoferrin protects against acetaminophen-induced liver injury in mice, Hepatology, 2010, 51, 3Direct Link:
- 106, , , Long-term outcome following liver transplantation for paracetamol overdose, Transplant International, 2010, 23, 5Direct Link:
- 107, , , , Long-term prognosis for transplant-free survivors of paracetamol-induced acute liver failure, Alimentary Pharmacology & Therapeutics, 2010, 32, 7Direct Link:
- 108, , , Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine, Hepatology, 2010, 51, 1Direct Link:
- 109, , , , , Novel nanostructure electrochemical sensor for electrocatalytic determination of norepinephrine in the presence of high concentrations of acetaminophene and folic acid, Applied Catalysis A: General, 2010, 378, 2, 195
- 110, , Out of the Medicine Closet: Time to Talk Straight About Prescription Drug Abuse, Clinical Pharmacology & Therapeutics, 2010, 88, 3, 279
- 111
- 112
- 113
- 114, , , , , , , , , Polypharmazie und Schmerztherapie, Wiener Medizinische Wochenschrift, 2010, 160, 11-12, 286
- 115, , , , , Probing oxidative stress in single erythrocytes with Raman Tweezers, Journal of Photochemistry and Photobiology B: Biology, 2010, 100, 3, 113
- 116, , , , , , Protective effect of ghrelin on acetaminophen-induced liver injury in rat, Peptides, 2010, 31, 11, 2114
- 117, , , , , , , Relationship between Serum Acetaminophen Concentration and N-Acetylcysteine-Induced Adverse Drug Reactions, Basic & Clinical Pharmacology & Toxicology, 2010, 107, 3Direct Link:
- 118, , , , Removal of Opioid/Acetaminophen Combination Prescription Pain Medications: Assessing the Evidence for Hepatotoxicity and Consequences of Removal of These Medications, Pain Medicine, 2010, 11, 3Direct Link:
- You have free access to this content119, , , , Review article: the current management of acute liver failure, Alimentary Pharmacology & Therapeutics, 2010, 31, 3Direct Link:
- 120, , , , , , , , , , , Risk of Hepatotoxicity-Related Hospitalizations among Patients Treated with Opioid/Acetaminophen Combination Prescription Pain Medications, Pain Medicine, 2010, 11, 11Direct Link:
- 121, , , , , Survey of patient knowledge related to acetaminophen recognition, dosing, and toxicity, Journal of the American Pharmacists Association, 2010, 50, 4, 485
- 122, , , , Survey of Physician Knowledge and Counseling Practices Regarding Acetaminophen, Journal of Patient Safety, 2010, 6, 4, 216
- 123, , , , , Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice, Biochemical Pharmacology, 2010, 79, 9, 1363
- 124, The Case for Limiting Acetaminophen-Related Deaths: Smaller Doses and Unbundling the Opioid–Acetaminophen Compounds, Clinical Pharmacology & Therapeutics, 2010, 88, 3, 289
- 125, , , , , , The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol – a randomized study, Alimentary Pharmacology & Therapeutics, 2010, 32, 3Direct Link:
- 126, The Emergency Department Evaluation, Management, and Treatment of Back Pain, Emergency Medicine Clinics of North America, 2010, 28, 4, 811
- 127, , , , , The Oxygen Tension Modulates Acetaminophen-Induced Mitochondrial Oxidant Stress and Cell Injury in Cultured Hepatocytes, Toxicological Sciences, 2010, 117, 2, 515
- 128, , , , , , Use of Pharmaco-Metabonomics for Early Prediction of Acetaminophen-Induced Hepatotoxicity in Humans, Clinical Pharmacology & Therapeutics, 2010, 88, 1, 45
- 129
- 130
- 131
- 132
- 133, , , , Acetaminophen Hepatotoxicity and Acute Liver Failure, Journal of Clinical Gastroenterology, 2009, 43, 4, 342
- 134, , , Acetaminophen Hepatotoxicity: Current Management, Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, 2009, 76, 1Direct Link:
- 135, , , Akutes Leberversagen aus der Sicht des Internisten und des Chirurgen, Der Gastroenterologe, 2009, 4, 4, 285
- 136, , , , , , , , , , Bacterial- and Viral-Induced Inflammation Increases Sensitivity to Acetaminophen Hepatotoxicity, Journal of Toxicology and Environmental Health, Part A, 2009, 73, 1, 58
- 137, , , , , , , Beta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury, The American Journal of Pathology, 2009, 175, 3, 1056
- 138, , , , , , Co-medications That Modulate Liver Injury and Repair Influence Clinical Outcome of Acetaminophen-Associated Liver Injury, Clinical Gastroenterology and Hepatology, 2009, 7, 8, 882
- 139, Comment on: Severe hemolytic anemia and fatal hepatic failure associated with nimesulide, Digestive and Liver Disease, 2009, 41, 6, 450
- 140, , , , , , , , , , , , , , , , , , , Comparison of the 20-Hour Intravenous and 72-Hour Oral Acetylcysteine Protocols for the Treatment of Acute Acetaminophen Poisoning, Annals of Emergency Medicine, 2009, 54, 4, 606
- 141, Editorial - Acetaminophen: Is It Time for a Change in Utilization to Decrease the Risk of Hepatotoxicity?, Hospital Pharmacy, 2009, 44, 10, 843
- 142, , , , , , , , Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose, Biochemical Pharmacology, 2009, 77, 10, 1621
- 143, , , , , , Emergency department visits attributed to selected analgesics, United States, 2004–2005, Pharmacoepidemiology and Drug Safety, 2009, 18, 3Direct Link:
- 144, , Hépatite fulminante et sub-fulminante : étiologie et traitement, La Presse Médicale, 2009, 38, 9, 1290
- 145, , Hepatitis C, alcohol abuse, and unintentional overdoses are risk factors for acetaminophen-related hepatotoxicity, Hepatology, 2009, 49, 4Direct Link:
- 146
- 147, , Management and Treatment of Patients With Cirrhosis and Portal Hypertension: Recommendations From the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program, The American Journal of Gastroenterology, 2009, 104, 7, 1802
- 148, , Management of acute liver failure, Nature Reviews Gastroenterology & Hepatology, 2009, 6, 9, 542
- 149, , , Opioid Prescribing Practices in Chronic Pain Management: Guidelines Do Not Sufficiently Influence Clinical Practice, The Journal of Pain, 2009, 10, 10, 1051
- 150, , , , , , Outcome of acute liver failure in the elderly, Liver Transplantation, 2009, 15, 11Direct Link:
- 151, Practical management of acute liver failure in the intensive care unit, Current Opinion in Critical Care, 2009, 15, 2, 163
- 152, , , , , , , , , Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis, Organic & Biomolecular Chemistry, 2009, 7, 24, 5103
- 153, , , , , Racial and Ethnic Differences in Presentation, Etiology, and Outcomes of Acute Liver Failure in the United States, Clinical Gastroenterology and Hepatology, 2009, 7, 10, 1121
- 154, Recent status of drug-induced liver injury, Hepatology Research, 2009, 39, 1Direct Link:
- 155, , , Risk-adjusted monitoring of survival times, Statistics in Medicine, 2009, 28, 9Direct Link:
- 156
- 157, , , , , , , Serum α-NH2-butyric acid may predict spontaneous survival in pediatric acute liver failure, Pediatric Transplantation, 2009, 13, 2Direct Link:
- 158, , , Special Issues in the Management of Chronic Pain in Older Adults, Pain Medicine, 2009, 10, S2Direct Link:
- 159, , , , The Role of Etiology in the Hyperamylasemia of Acute Liver Failure, The American Journal of Gastroenterology, 2009, 104, 3, 592
- 160, , , , , , , , , The utilization of liver transplantation in the management of acute liver failure: Comparison between acetaminophen and non-acetaminophen etiologies, Liver Transplantation, 2009, 15, 6Direct Link:
- 161, , , Thinking through acetaminophen hepatotoxicity and liver transplantation: Choosing worthy recipients, Liver Transplantation, 2009, 15, 6Direct Link:
- 162, , Transplantation hépatique pour hépatite fulminante, Gastroentérologie Clinique et Biologique, 2009, 33, 1, 51
- 163
- 164, , , , Use of Over-the-Counter Analgesics Is Not Associated With Acute Decompensation in Patients With Cirrhosis, Clinical Gastroenterology and Hepatology, 2009, 7, 9, 994
- 165, , , , , , , A metabonomic characterization of CCl4-induced acute liver failure using partial least square regression based on the GC/MS metabolic profiles of plasma in mice, Journal of Chromatography B, 2008, 870, 2, 178
- 166, , , , , , , , , Acetaminophen-Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents With Acetaminophen Overdose, Clinical Pharmacology & Therapeutics, 2008, 84, 6, 684
- 167, , Acetaminophen-induced nephrotoxicity: Pathophysiology, clinical manifestations, and management, Journal of Medical Toxicology, 2008, 4, 1, 2
- 168, Acetaminophen-related acute liver failure in the United States, Hepatology Research, 2008, 38,Direct Link:
- 169
- 170, Acute Liver Failure Including Acetaminophen Overdose, Medical Clinics of North America, 2008, 92, 4, 761
- 171, , , , , Acute liver failure: Summary of a workshop, Hepatology, 2008, 47, 4Direct Link:
- 172, , An evidence-based update of the use of analgesics in dentistry, Periodontology 2000, 2008, 46, 1Direct Link:
- 173, , , , , , Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute-on-chronic liver failure, Liver International, 2008, 28, 5Direct Link:
- 174, , Balancing Drug Risk and Benefit: Toward Refining the Process of FDA Decisions Affecting Patient Care, The American Journal of Gastroenterology, 2008, 103, 4, 815
- 175, , Biomarkers of drug-induced adverse events, Expert Review of Clinical Pharmacology, 2008, 1, 1, 81
- 176
- 177, , , , Comparison of S-adenosyl-l-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose, Toxicology, 2008, 244, 1, 25
- 178, , , , , , , , , , Dynamic metabonomic analysis of BALB/C mice with different outcomes after D-galactosamine/lipopolysaccharide–induced fulminant hepatic failure, Liver Transplantation, 2008, 14, 11Direct Link:
- 179
- 180, , Etiology and prognosis of fulminant hepatitis in adults, Liver Transplantation, 2008, 14, S2Direct Link:
- 181, , , , Evaluation of a urine screen for acetaminophen, Journal of Medical Toxicology, 2008, 4, 2, 96
- 182, , Evidence and consequences of spectrum bias in studies of criteria for liver transplant in paracetamol hepatotoxicity, QJM, 2008, 101, 9, 723
- 183, , , , , , , , , , False positive acetaminophen concentrations in patients with liver injury, Clinica Chimica Acta, 2008, 391, 1-2, 24
- 184, , Fulminant Hepatic Failure: When the Hepatologist Meets the Neurointensivist, Neurocritical Care, 2008, 9, 1, 1
- 185, , , Hepatitis C is a predictor of acute liver injury among hospitalizations for acetaminophen overdose in the United States: A nationwide analysis, Hepatology, 2008, 48, 4Direct Link:
- 186, How safe is acetaminophen for the treatment of pain and fever in newly-abstinent patients with alcoholism?, Nature Clinical Practice Gastroenterology & Hepatology, 2008, 5, 3, 134
- 187, , , , How to Protect Against Acetaminophen: Don't Ask for JUNK, Gastroenterology, 2008, 135, 4, 1047
- 188
- 189, Innate immunity and acetaminophen-induced liver injury: Why so many controversies?, Hepatology, 2008, 48, 3Direct Link:
- 190, , , Metabolomics: a tool for personalizing medicine?, Personalized Medicine, 2008, 5, 5, 495
- 191, , , , , , , Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS, Journal of Chromatography B, 2008, 871, 2, 328
- 192, , , , , , , , , Outcomes of living donor liver transplantation for acute liver failure: The adult-to-adult living donor liver transplantation cohort study, Liver Transplantation, 2008, 14, 9Direct Link:
- 193, , , , , , , , , , , Parallelogram Approach Using Rat-Human In Vitro and Rat In Vivo Toxicogenomics Predicts Acetaminophen-induced Hepatotoxicity in Humans, Toxicological Sciences, 2008, 107, 2, 544
- 194, Post-operative oral surgery pain: a review, Oral Surgery, 2008, 1, 4Direct Link:
- 195, , Rapid diagnosis of Wilson disease in acute liver failure: No more waiting for the ceruloplasmin level?, Hepatology, 2008, 48, 4Direct Link:
- 196Recommendations for use of selective and nonselective nonsteroidal antiinflammatory drugs: An American College of Rheumatology white paper, Arthritis Care & Research, 2008, 59, 8Direct Link:
- 197
- 198, , Review article: the use of potentially hepatotoxic drugs in patients with liver disease, Alimentary Pharmacology & Therapeutics, 2008, 28, 9Direct Link:
- 199, , , , The effect of molecular adsorbent recirculating system treatment on survival, native liver recovery, and need for liver transplantation in acute liver failure patients, Transplant International, 2008, 21, 9Direct Link:
- 200, , , , , , , , The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system, Hepatology, 2008, 48, 4Direct Link:
- 201, , , , , , Therapeutic Hypothermia for Acute Liver Failure: Toward a Randomized, Controlled Trial in Patients with Advanced Hepatic Encephalopathy, Neurocritical Care, 2008, 9, 1, 90
- 202
- 203, , , , , , , , , , Use of Over-the-Counter Analgesics in Patients with Chronic Liver Disease, Drug Safety, 2008, 31, 3, 261
- 204, , Uso de analgésicos en pacientes con hepatopatÃa, Medicina ClÃnica, 2008, 131, 15, 591
- 205
- 206, , A Retrospective Study of the Etiologies and Outcomes of Patients Admitted to a University Hospital with Presumed Acetaminophen Toxicity, Hospital Pharmacy, 2007, 42, 2, 126
- 207
- 208, , Acetaminophen safety and hepatotoxicity – where do we go from here?, Expert Opinion on Drug Safety, 2007, 6, 4, 341
- 209
- 210, Acetaminophen toxicity: Changing perceptions on a social/medical issue, Hepatology, 2007, 46, 4Direct Link:
- 211, , Acetaminophen Usage Patterns and Concentrations of Glutathione and γ-Glutamyl Transferase in Alcoholic Subjects, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2007, 27, 11Direct Link:
- 212
- 213
- 214, , Causality Assessment of Drug-Induced Hepatotoxicity: Promises and Pitfalls, Clinics in Liver Disease, 2007, 11, 3, 477
- You have free access to this content215, , , Clinical pharmacology in the geriatric patient, Fundamental & Clinical Pharmacology, 2007, 21, 3Direct Link:
- 216, , Does Therapeutic Use of Acetaminophen Cause Acute Liver Failure?, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2007, 27, 9Direct Link:
- 217, Drug metabolite profiling and elucidation of drug-induced hepatotoxicity, Expert Opinion on Drug Metabolism & Toxicology, 2007, 3, 3, 407
- 218
- 219, , , , Elevated troponin I levels in acute liver failure: Is myocardial injury an integral part of acute liver failure?, Hepatology, 2007, 45, 6Direct Link:
- 220, , Etiologies of acute liver failure: Location, location, location!, Liver Transplantation, 2007, 13, 10Direct Link:
- 221, Evidence for Practice: Education About the Dangers of Acetaminophen, Journal of Emergency Nursing, 2007, 33, 4, 327
- 222
- 223, How to decide when to list a patient with acute liver failure for liver transplantation? Clichy or King’s College criteria, or something else?, Journal of Hepatology, 2007, 46, 4, 554
- 224, , , , , , Interés clÃnico de la semivida de eliminación del paracetamol como complemento al nomograma de Rumack en la valoración de la intoxicación por paracetamol, Medicina ClÃnica, 2007, 129, 13, 501
- 225
- 226, , , , Plasminogen Activator Inhibitor-1 Limits Liver Injury and Facilitates Regeneration after Acetaminophen Overdose, Toxicological Sciences, 2007, 104, 2, 419
- 227, , , , , Population-Based Surveillance for Acute Liver Failure, The American Journal of Gastroenterology, 2007, 102, 11, 2459
- 228, Predicting outcome in acute liver failure: Are we there yet?, Liver Transplantation, 2007, 13, 9Direct Link:
- 229, , , , , , , Predictive value of actin-free Gc-globulin in acute liver failure, Liver Transplantation, 2007, 13, 9Direct Link:
- 230, Prognostication in acute liver failure: A tool or an anchor?, Liver Transplantation, 2007, 13, 6Direct Link:
- 231, , , Safety and efficacy of intravenous Nâ€acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database, Current Medical Research and Opinion, 2007, 23, 10, 2359
- 232, , Sorbent-based artificial liver devices: principles of operation, chemical effects and clinical results, Expert Review of Medical Devices, 2007, 4, 6, 839
- 233, , , , , , , , , , Terbinafine-induced hepatic failure requiring liver transplantation, Liver Transplantation, 2007, 13, 1Direct Link:
- 234, , , Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study, Hepatology, 2006, 43, 4Direct Link:
- 235, , Acute liver failure in the newborn, Drug Discovery Today: Disease Mechanisms, 2006, 3, 4, 415
- 236
- 237, , , , , , , Alpha-fetoprotein and prognosis in acute liver failure, Liver Transplantation, 2006, 12, 12Direct Link:
- 238, , , , , Case Report: Fulminant Hepatic Failure Involving Duloxetine Hydrochloride, Clinical Gastroenterology and Hepatology, 2006, 4, 7, 912
- 239
- 240
- 241, , Drug-induced liver injury: Summary of a single topic clinical research conference, Hepatology, 2006, 43, 3Direct Link:
- 242, How relevant are neutrophils for acetaminophen hepatotoxicity?, Hepatology, 2006, 43, 6Direct Link:
- 243, Increasing US incidence of acute liver failure caused by paracetamol overdose, Nature Clinical Practice Gastroenterology & Hepatology, 2006, 3, 3, 122
- 244, Indeterminate acute liver failure: A riddle wrapped in a mystery inside an enigma, Hepatology, 2006, 44, 3Direct Link:
- 245, ISMP Medication Error Report Analysis - IV Potassium Given Epidurally: Getting to the “Route†of the Problem; Acetaminophen Toxicity: More Risk Exposure than We Thought?; Color Consistency, Hospital Pharmacy, 2006, 41, 7, 621
- 246, , , , , , King's criteria, APACHE II, and SOFA scores in acute liver failure, Hepatology, 2006, 43, 4Direct Link:
- 247, Mitochondrial involvement in drug-induced hepatic injury, Chemico-Biological Interactions, 2006, 163, 1-2, 145
- 248
- 249
- 250, , Role of innate immunity in acetaminophen-induced hepatotoxicity, Expert Opinion on Drug Metabolism & Toxicology, 2006, 2, 4, 493
- 251, , , State of the art of paracetamol in acute pain therapy, Current Opinion in Anaesthesiology, 2006, 19, 5, 562
- 252, , , , , , , , Synthesis of new chemical entities from paracetamol and NSAIDs with improved pharmacodynamic profile, Bioorganic & Medicinal Chemistry, 2006, 14, 24, 8701
- 253, Broadening the view of acetaminophen hepatotoxicity, Hepatology, 2005, 42, 6Direct Link:
- 254, , Abnormal Liver Function Tests: Diagnostic Approach,Direct Link:
- 255, , , , , , , , , Acupuncture for peripheral joint osteoarthritis, The Cochrane Library,Direct Link:
- 256, Acute Liver Failure,Direct Link:
- 257, Acute Liver Failure,Direct Link:
- 258, , Acute Liver Failure,Direct Link:
- 259, , , Animal Models of Idiosyncratic, Drug-Induced Liver Injury: Emphasis on the Inflammatory Stress Hypothesis, Encyclopedia of Drug Metabolism and Interactions,Direct Link:
- 260, , Drug-Induced Liver Injury,Direct Link:
- 261, , Drug-Induced Liver Injury,Direct Link:
- 262, , Fulminant Hepatic Failure,Direct Link:
- 263, , , Fulminant Hepatic Failure: Treatment,Direct Link:
- 264, , , Interventions for paracetamol (acetaminophen) overdose, The Cochrane Library,Direct Link:
- 265, Jaundice,Direct Link: