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Liver Failure and Liver Disease
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Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study†‡
Article first published online: 29 NOV 2005
DOI: 10.1002/hep.20948
Copyright © 2005 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Larson, A. M., Polson, J., Fontana, R. J., Davern, T. J., Lalani, E., Hynan, L. S., Reisch, J. S., Schiødt, F. V., Ostapowicz, G., Shakil, A. O. and Lee, W. M. (2005), Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study. Hepatology, 42: 1364–1372. doi: 10.1002/hep.20948
- †
See Editorial on Page 1252.
- ‡
Potential conflict of interest: Nothing to report.
Publication History
- Issue published online: 29 NOV 2005
- Article first published online: 29 NOV 2005
- Manuscript Accepted: 12 SEP 2005
- Manuscript Received: 24 JUN 2005
Funded by
- NIDDK. Grant Number: R-01-DK58639
- Stephen B. Tips Fund at Northwestern University
- FDA. Grant Number: FD-R-001661
- NIH. Grant Numbers: R-O3 DK52827, R-01 DK58369
- Stephen B. Tips Fund of Northwestern Medical Foundation
- Jeanne Roberts Fund of the Southwestern Medical Foundation
- AASLD/Schering Research Fellowship
References
- 1. Acetaminophen hepatotoxicity. Annu Rev Med 1984; 35: 577–593.
- 2, . Acute liver necrosis following overdose of paracetamol. Br Med J 1966; 5512: 497–499.
- 3, . Liver damage and impaired glucose tolerance after paracetamol overdosage. Br Med J 1966; 5512: 506–507.
- 4, . Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. HEPATOLOGY 1995; 22: 767–773.Direct Link:
- 5. Hepatic effects of acetaminophen. Enhanced toxicity in alcoholics. J Clin Gastroenterol 1987; 9: 180–185.
- 6, . Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA 1994; 272: 1845–1850.
- 7, , , . Acetaminophen toxicity in an urban county hospital N Engl J Med 1997; 337: 1112–1117.
- 8. Acetaminophen misconceptions. HEPATOLOGY 2004; 40: 10–15.Direct Link:
- 9, . Paracetamol (acetaminophen) poisoning. Lancet 1995; 346: 547–552.
- 10, , , . Prediction of hepatic encephalopathy in paracetamol overdose: a prospective and validated study. Scand J Gastroenterol 1999; 34: 723–728.
- 11, , , , , . Acute hepatic necrosis with stupor or coma. An analysis of thirty-one patients. Medicine (Baltimore) 1969; 48: 151–172.
- 12, , , , , , et al. Acute hepatic failure: the emerging role of orthotopic liver transplantation. Mayo Clin Proc 1989; 64: 424–428.
- 13, , , , , , et al. Etiology and outcome for 295 patients with acute liver failure in the United States. Liver Transpl Surg 1999; 5: 29–34.Direct Link:
- 14, , , . Management of Acetaminophen Hepatotoxicity: A Survey of Practicing Physicians. J Clin Outcomes Management 2001: 25–32.
- 15, . The management of fulminant hepatic failure. In: PopperH, SchaffnerF, eds. Progress in Liver Diseases. New York: Grune & Stratton, 1970: 282–292.
- 16, , , , , , et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 2002; 137: 947–954.
- 17, , , . APACHE II: a severity of disease classification system. Crit Care Med 1985; 13: 818–829.
- 18, , , . Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 1989; 97: 439–445.
- 19, , , , , , et al. A model to predict survival in patients with end-stage liver disease. HEPATOLOGY 2001; 33: 464–470.Direct Link:
- 20, . Indications for orthotopic liver transplantation in fulminant liver failure. HEPATOLOGY 1994; 20: S5–10S.
- 21, . Acetaminophen-induced hepatotoxicity: predisposing factors and treatments. Adv Intern Med 1997; 42: 453–483.
- 22, , , , . Acute liver failure: clinical features, outcome analysis, and applicability of prognostic criteria. Liver Transpl 2000; 6: 163–169.
- 23US Department of Health and Human Services (DHHS). Third National Health and Nutrition Examination Survey, 1988–1994, NHANES III Second Laboratory Data File. (CD-ROM, Series 11, No 2A). Hyattsville, MD: Centers for Disease Control and Prevention, 1998.
- 24, . Paracetamol hepatotoxicity and alcohol consumption in deliberate and accidental overdose. Q J Med 2000; 93: 341–349.
- 25, , , . The Danish liver transplantation program and patients with serious acetaminophen intoxication. Transplant Proc 1995; 27: 3519–3520.
- 26, , , . Etiology and outcome of fulminant hepatic failure managed at an Australian liver transplant unit. J Gastroenterol Hepatol 2004; 19: 154–159.Direct Link:
- 27, , , , , , et al. Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury. HEPATOLOGY 1999; 29: 451–463.Direct Link:
- 28, . Vicodin-induced fulminant hepatic failure. Anesthesiology 1993; 79: 857–860.
- 29, , , . Does hypothermia protect against the development of hepatitis in paracetamol overdose? Anaesthesia 1992; 47: 789–791.Direct Link:
- 30, , , , , , et al. Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther 2001; 299: 998–1006.
- 31
- 32, , . Knowledge about acetaminophen toxicity among emergency department visitors. Vet Hum Toxicol 2002; 44: 370–373.
- 33, , , , , , et al. Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and after study. BMJ 2001; 322: 1203–1207.
- 34, , . Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. HEPATOLOGY 2002; 35: 876–882.Direct Link:
- 35, , , , , , et al. Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults. Clin Pharmacol Ther 2000; 67: 591–599.
- 36. Paracetamol, alcohol and the liver. Br J Clin Pharmacol 2000; 49: 291–301.Direct Link:
- 37. Classification, etiology, and considerations of outcome in acute liver failure. Semin Liver Dis 1996; 16: 343–348.
- 38, . Management of acetaminophen toxicity. In: KrawittE, ed. Medical Management of Liver Disease. New York: Marcel Dekker, 1999: 325–337.
- 39, , , . Emergency liver transplantation for acute liver failure: evaluation of London and Clichy criteria. J Hepatol 1993; 17: 124–127.
- 40, , , , . Earlier identification of patients at risk from acetaminophen-induced acute liver failure. Crit Care Med 1998; 26: 279–284.
- 41. Changing patterns of causation and the use of transplantation in the United kingdom. Semin Liver Dis 2003; 23: 227–237.
- 42, , , , , . Admissions to hospital for deliberate self-harm in England 1995–2000: an analysis of hospital episode statistics. J Public Health Med 2002; 24: 179–183.
- 43, , , , , , et al. Use of paracetamol for suicide and non-fatal poisoning in the UK and France: are restrictions on availability justified? J Epidemiol Community Health 1997; 51: 175–179.
- 44, , , , . Paracetamol pack size restriction: the impact on paracetamol poisoning and the over-the-counter supply of paracetamol, aspirin and ibuprofen. Pharmacoepidemiol Drug Saf 2002; 11: 329–331.Direct Link:
- 45, , . Severity of overdose after restriction of paracetamol availability: retrospective study. BMJ 2000; 321: 926–927.
- 46, , , , , , et al. UK legislation on analgesic packs: before and after study of long term effect on poisonings. BMJ 2004; 329: 1076.

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