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Supplementary material for this article can be found on the H EPATOLOGY website ( http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html ).

FilenameFormatSizeDescription
jws-hep.20949.fig1.tif80KExpression of the proteins encoded by NF-κB target genes (c-IAP2, Bcl-X L , and iNOS) in obese mice. Mice received ethanol or water for four days, and were killed 2 hours after the last administration. Pentoxifylline (PTX) was administered 1 hour before each ethanol administration. Mitochondrial and cytosolic fractions were isolated. Blots are representative of experiments performed with 5 to 8 mice per group.
jws-hep.20949.fig2.tif38KMitochondrial DNA in naive or intoxicated, lean or obese mice. Mice received ethanol or water for four days, and were killed 2 hours after the last administration. Total hepatic DNA was isolated and mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) were assessed by slot blot hybridization. (A) Representative slot blots. (B) mtDNA/nDNA hybridization ratios. Results are means &&num;177; SEM for 7 to 8 mice. &&num;8224;Significantly different from na&&num;239;ve or intoxicated lean mice ( P< 0.05).
jws-hep.20949.fig3.tif3KHepatic thiobarbituric acid-reactants in na&&num;239;ve or intoxicated, lean or obese mice. Mice received ethanol or water for four days, and were killed 2 hours after the last administration. Pentoxifylline (PTX) was administered to obese mice one hour before each ethanol administration. Hepatic thiobarbituric acid-reactants were assessed in liver homogenates, and expressed as malondialdehyde (MDA) equivalents (mean &&num;177; SEM) for 4 to 9 mice. &&num;8224;Significantly different from intoxicated lean mice ( P< 0.05).

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