Alcohol and oxidative liver injury

Authors

  • Aparajita Dey,

    1. Department of Pharmacology & Biological Chemistry, Mount Sinai School of Medicine, New York, NY
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  • Arthur I. Cederbaum

    Corresponding author
    1. Department of Pharmacology & Biological Chemistry, Mount Sinai School of Medicine, New York, NY
    • Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029
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    • fax: 212-996-7214


  • Potential conflict of interest: Nothing to report.

Abstract

Acute and chronic ethanol treatment has been shown to increase the production of reactive oxygen species, lower cellular antioxidant levels, and enhance oxidative stress in many tissues, especially the liver. Ethanol-induced oxidative stress plays a major role in the mechanisms by which ethanol produces liver injury. Many pathways play a key role in how ethanol induces oxidative stress. This review summarizes some of the leading pathways and discusses the evidence for their contribution to alcohol-induced liver injury. Many of the seminal reports in this topic have been published in Hepatology , and it is fitting to review this research area for the 25th Anniversary Issue of the Journal. (Hepatology 2006;43:S63–S74.)

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