Potential conflict of interest: Nothing to report.
Treating hepatitis C: Can you teach old dogs new tricks?†
Article first published online: 29 NOV 2005
Copyright © 2005 American Association for the Study of Liver Diseases
Volume 42, Issue 6, pages 1455–1458, December 2005
How to Cite
Rice, C. M. and You, S. (2005), Treating hepatitis C: Can you teach old dogs new tricks?. Hepatology, 42: 1455–1458. doi: 10.1002/hep.20975
- Issue published online: 29 NOV 2005
- Article first published online: 29 NOV 2005
- Public Health Service. Grant Numbers: CA57973, AI40034
- Greenberg Medical Research Institute
Viruses depend on host-derived factors for their efficient genome replication. Here, we demonstrate that a cellular peptidyl-prolyl cis-trans isomerase (PPIase), cyclophilin B (CyPB), is critical for the efficient replication of the hepatitis C virus genome. CyPB interacted with the HCV RNA polymerase NS5B to directly stimulate its RNA binding activity. Both the RNA interference (RNAi)-mediated reduction of endogenous CyPB expression and the induced loss of NS5B binding to CyPB decreased the levels of HCV replication. Thus, CyPB functions as a stimulatory regulator of NS5B in HCV replication machinery. This regulation mechanism for viral replication identifies CyPB as a target for antiviral therapeutic strategies.