SEARCH

SEARCH BY CITATION

References

  • 1
    Jungermann K, Katz N. Functional specialization of different hepatocyte populations. Physiol Rev 1989; 69: 708764.
  • 2
    Gebhardt R. Metabolic zonation of the liver: regulation and implications for liver function. Pharmacol Ther 1992; 53: 275354.
  • 3
    Jungermann K. Zonation of metabolism and gene expression in liver. Histochem Cell Biol 1995; 103: 8191.
  • 4
    Christoffels VM, Sassi H, Ruijter JM, Moorman AF, Grange T, Lamers WH. A mechanistic model for the development and maintenance of portocentral gradients in gene expression in the liver. HEPATOLOGY 1999; 29: 11801192.
  • 5
    Gebhardt R, Mecke D. Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture. EMBO J 1983; 2: 567570.
  • 6
    Wolf CR, Moll E, Friedberg T, Oesch F, Buchmann A, Kuhlmann WD, et al. Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P450, compared with three further P450-isoenzymes, NADPH P450-reductase, glutathione transferases and microsomal epoxide hydrolase. Carcinogenesis 1984; 5: 9931001.
  • 7
    Buchmann A, Kunz W, Wolf CR, Oesch F, Robertson LW. Polychlorinated biphenyls, classified as either phenobarbital- or 3-methylcholanthrene-type inducers of cytochrome P-450, are both hepatic tumor promoters in diethylnitrosamine-initiated rats. Cancer Lett 1986; 32: 243253.
  • 8
    Tritscher AM, Goldstein JA, Portier CJ, McCoy Z, Clark GC, Lucier GW. Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver. Cancer Res 1992; 52: 34363442.
  • 9
    Kuo FC, Darnell JE Jr. Evidence that interaction of hepatocytes with the collecting (hepatic) veins triggers position-specific transcription of the glutamine synthetase and ornithine aminotransferase genes in the mouse liver. Mol Cell Biol 1991; 11: 60506058.
  • 10
    Aydinlik H, Nguyen TD, Moennikes O, Buchmann A, Schwarz M. Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. Oncogene 2001; 20: 78127816.
  • 11
    Loeppen S, Schneider D, Gaunitz F, Gebhardt R, Kurek R, Buchmann A, et al. Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. Cancer Res 2002; 62: 56855688.
  • 12
    Loeppen S, Koehle C, Buchmann A, Schwarz M. A β-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors. Carcinogenesis 2005; 26: 239248.
  • 13
    Stahl S, Ittrich C, Marx-Stoelting P, Köhle C, Altug-Teber Ö, Riess O, et al. Genotype-phenotype relationships in hepatocellular tumors from mice and man. HEPATOLOGY 2005; 42: 353361.
  • 14
    Jaworski M, Hailfinger S, Buchmann A, Hergenhahn M, Hollstein M, Ittrich C, et al. Human p53 knock-in (HUPKI) mice do not differ in liver tumor response from their counterparts with murine p53. Carcinogenesis 2005; 26: 18291834.
  • 15
    Moennikes O, Buchmann A, Romualdi A, Ott T, Werringloer J, Willecke K, et al. Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice. Cancer Res 2000; 60: 50875091.
  • 16
    Buchmann A, Bauer-Hofmann R, Mahr J, Drinkwater NR, Luz A, Schwarz M. Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis. Proc Natl Acad Sci U S A 1991; 88: 911911.
  • 17
    Gebhardt R: Isolation of periportal and pericentral hepatocytes. In: PhillipsIR, ShephardEA, eds. Methods in Molecular Biology: Cytochrome P450 protocols. Volume 108. Totowa, NJ: Humana Press Inc, 1998: 319328.
  • 18
    Cadoret A, Ovejero C, Terris B, Souil E, Levy L, Lamers WH, et al. New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism. Oncogene 2002; 21: 82938301. 19
  • 19
    Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K, Negishi M. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 1999; 19: 63186322.
  • 20
    Dingemanse MA, De Jonge WJ, De Boer PA, Mori M, Lamers WH, Moorman AF. Development of the ornithine cycle in rat liver: zonation of a metabolic pathway. HEPATOLOGY 1996; 24: 407411.
  • 21
    Kuo FC, Hwu WL, Valle D, Darnell JE Jr. Colocalization in pericentral hepatocytes in adult mice and similarity in developmental expression pattern of ornithine aminotransferase and glutamine synthetase mRNA. Proc Natl Acad Sci U S A 1991; 88: 94689472.
  • 22
    Tosh D, Alberti GM, Agius L. Glucagon regulation of gluconeogenesis and ketogenesis in periportal and perivenous rat hepatocytes: heterogeneity of hormone action and of the mitochondrial redox state. Biochem J 1988; 256: 197204.
  • 23
    Butz S, Larue L. Expression of catenins during mouse embryonic development and in adult tissues. Cell Adhes Commun 1995; 3: 337352.
  • 24
    Willert K, Nusse R. Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev 1998; 8: 95102.
  • 25
    Lustig B, Behrens J. The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol 2003; 129: 199221.
  • 26
    Jamora C, DasGupta R, Kocieniewski P, Fuchs E. Links between signal transduction, transcription and adhesion in epithelial bud development. Nature 2003; 422: 317322.
  • 27
    Gebhardt R, Schuler M, Schorner D. The spontaneous induction of glutamine synthetase in pig hepatocytes cocultured with RL-ET-14 cells is completely inhibited by trijodothyronine and okadaic acid. Biochem Biophys Res Commun 1998; 246: 895898.
  • 28
    Kruithof-de Julio M, Labruyere WT, Ruijter JM, Vermeulen JL, Stanulovic V, Stallen JM, et al. The RL-ET-14 cell line mediates expression of glutamine synthetase through the upstream enhancer/promoter region. J Hepatol 2005; 43: 126131.
  • 29
    Lindros KO, Oinonen T, Johansson I, Ingelman-Sundberg M. Selective centrilobular expression of the aryl hydrocarbon receptor in rat liver. J Pharmacol Exp Ther 1997; 280: 506511.
  • 30
    Jaworski M, Buchmann A, Bauer P, Riess O, Schwarz M. B-raf and Ha-ras mutations in chemically induced mouse liver tumors. Oncogene 2005; 24: 12901295.
  • 31
    Reiners JJ Jr, Jones CL, Hong N, Clift RE, Elferink C. Downregulation of aryl hydrocarbon receptor function and cytochrome P450 1A1 induction by expression of Ha-ras oncogenes. Mol Carcinog 1997; 19: 91100.
  • 32
    Hohne M, Becker-Rabbenstein V, Kahl GF, Taniguchi H. Regulation of cytochrome P-450 CYPIA1 gene expression and proto-oncogene expression by growth factors in primary hepatocytes. FEBS Lett 1990; 273: 219222.
  • 33
    Heder AF, Hirsch-Ernst KI, Bauer D, Kahl GF, Desel H. Induction of cytochrome P450 2B1 by pyrethroids in primary rat hepatocyte cultures. Biochem Pharmacol 2001; 62: 7179.
  • 34
    Gaunitz F, Deichsel D, Heise K, Werth M, Anderegg U, Gebhardt R. An intronic silencer element is responsible for specific zonal expression of glutamine synthetase in the rat liver. HEPATOLOGY 2005; 41: 12251232.
  • 35
    Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999; 398: 422426.
  • 36
    Desbois-Mouthon C, Cadoret A, Blivet-Van Eggelpoel MJ, Bertrand F, Cherqui G, Perret C, et al. Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation. Oncogene 2001; 20: 252259.
  • 37
    Wagenaar GT, Chamuleau RA, de Haan JG, Maas MA, de Boer PA, Marx F, et al. Experimental evidence that the physiological position of the liver within the circulation is not a major determinant of zonation of gene expression. HEPATOLOGY 1993; 18: 11441153.
  • 38
    Sekine S, Lan BY, Bedolli M, Feng SL, Hebrock M. Liver-specific loss of β-catenin blocks the activity of glutamine synthetase pathway and cytochrome P450 expression. HEPATOLOGY 2006. In press.