SEARCH

SEARCH BY CITATION

References

  • 1
    Yu MC, Yuan JM. Environmental factors and risk for hepatocellular carcinoma. Gastroenterology 2004; 127: S72S78.
  • 2
    Taper HS. The effect of estradiol-17-phenylproprionate and estradiol benzoate on N-nitrosomorpholine-induced liver carcinogenesis in ovariectomized female rats. Cancer 1978; 42: 462467.
  • 3
    Ghia M, Mereto E. Induction and promotion of gammaglutamyltranspeptidase-positive foci in the liver of female rats treated with ethinyl estradiol, clomiphene, tamoxifen and their associations. Cancer Lett 1989; 46: 195202.
  • 4
    Yager JD, Yager R. Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague-Dawley rats. Cancer Res 1980; 40: 36803685.
  • 5
    World Health Organization. Oral contraceptives and neoplasia. World Health Organ Tech Rep Ser 1992; 817: 2225.
  • 6
    International Agency for Research on Cancer. Monographs on the evaluation of carcinogenic risks to humans: hormonal contraception and postmenopausal therapy. Volume 72. Lyon: IARC Press, 1999.
  • 7
    Yager JD, Roebuck BD, Paluszcyk TL, Memoli VA. Effects of ethinyl estradiol and tamoxifen on liver DNA turnover and new synthesis and appearance of gamma glutamyl transpeptidase-positive foci in female rats. Carcinogenesis 1986; 7: 20072014.
  • 8
    Liehr JG. Is estradiol a genotoxic mutagenic carcinogen? Endocr Rev 2000; 21: 4054.
  • 9
    Yager JD. Endogenous estrogens as carcinogens through metabolic activation. J Natl Cancer Inst Monogr 2000; 27: 6773.
  • 10
    Chen JQ, Yager JD. Estrogen's effects on mitochondrial gene expression: mechanisms and potential contributions to estrogen carcinogenesis. Ann N Y Acad Sci 2004; 1028: 258272.
  • 11
    Hall JM, Couse JF, Korach KS. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 2001; 276: 3686936872.
  • 12
    Shi YE, Yager JD. Effects of the liver tumor promoter ethinyl estradiol on epidermal growth factor-induced DNA synthesis and epidermal growth factor receptor levels in cultured rat hepatocytes. Cancer Res 1989; 49: 35743580.
  • 13
    Ni N, Yager JD. The co-mitogenic effects of various estrogens for TGF-alpha-induced DNA synthesis in cultured female rat hepatocytes. Cancer Lett 1994; 84: 133140.
  • 14
    Shinozuka H. Stimulation of liver cell growth by direct mitogens. In: BannaschP, KanducD, PapaS, TagerJM, eds. Cell Growth and Oncogenesis. Basel: Birkhäuser, 1998: 213225.
  • 15
    Siiteri PK, Nisker JA, Hammond GL. Hormonal basis of risk factors for breast and endometrial cancer. In: IacobelliS, KingRJB, LindnerHR, LippmanME, eds. Hormones and Cancer. New York: Raven Press, 1980: 499505.
  • 16
    Feigelson HS, Henderson BE. Estrogens and breast cancer. Carcinogenesis 1996; 17: 22792284.
  • 17
    Klotz L, Hacker HJ, Klingmuller D, Bannasch P, Pfeifer U, Dombrowski F. Hepatocellular alterations after intraportal transplantation of ovarian tissue in ovariectomized rats. Am J Pathol 2000; 156: 16131626.
  • 18
    Metzger C, Mayer D, Hoffmann H, Bocker T, Hobe B, Benner A, et al. Sequential appearance and ultrastructure of amphophilic cell foci, adenomas, and carcinomas in the liver of male and female rats treated with dehydroepiandrosterone. Toxicol Pathol 1995; 23: 591605.
  • 19
    Bannasch P. Pathogenesis of hepatocellular carcinoma: sequential cellular, molecular, and metabolic changes. Prog Liver Dis 1996; 14: 161197.
  • 20
    Weber E, Moore MA, Bannasch P. Enzyme histochemical and morphological phenotype of amphophilic foci and amphophilic/tigroid cell adenomas in rat liver after combined treatment with dehydroepiandrosterone and N-nitrosomorpholine. Carcinogenesis 1988; 9: 10491054.
  • 21
    Yager JD, Campbell H, Longnecker D, Roebuck B, Benoit MC. Enhancement of hepatocarcinogenesis in female rats by ethinyl estradiol and mestranol but not estradiol. Cancer Res 1984; 44: 38623869.
  • 22
    Shimizu I, Yasuda M, Mizobuchi Y, Ma YR, Liu F, Shiba M, et al. Suppressive effect of oestradiol on chemical hepatocarcinogenesis in rats. Gut 1998; 42: 112119.
  • 23
    Tanaka K, Sakai H, Hashizume M, Hirohata T. Serum testosterone:estradiol ratio and the development of hepatocellular carcinoma among male cirrhotic patients. Cancer Res 2000; 60: 51065110.
  • 24
    Johnson FL, Lerner KG, Siegel M, Feagler JR, Majerus PW, Hartmann JR, et al. Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma. Lancet 1972; 2: 12731276.
  • 25
    Ishak KG. Hepatic lesions caused by anabolic and contraceptive steroids. Semin Liver Dis 1981; 1: 116128.
  • 26
    Creagh TM, Rubin A, Evans DJ. Hepatic tumours induced by anabolic steroids in an athlete. J Clin Pathol 1988; 41: 441443.
  • 27
    Yu MW, Chen CJ. Elevated serum testosterone levels and risk of hepatocellular carcinoma. Cancer Res 1993; 53: 790794.
  • 28
    Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz B, Umesono K, et al. The nuclear receptor superfamily: the second decade. Cell 1995; 83: 835839.
  • 29
    Reddy JK, Azarnoff DL, Hignite DD. Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature 1980; 283: 397398.
  • 30
    Hirsimaki P, Hirsimaki Y, Nieminen L, Payne BJ. Tamoxifen induces hepatocellular carcinoma in rat liver: a 1-year study with two antiestrogens. Arch Toxicol 1993; 67: 4954.
  • 31
    Montandon F, Williams GM. Comparison of DNA reactivity of the polyphenylethylene hormonal agents diethylstilbestrol, tamoxifen and toremifene in rat and hamster liver. Arch Toxicol 1994; 68: 272275.
  • 32
    Sargent LM, Dragan YP, Bahnub N, Wiley JE, Sattler CA, Schroeder P, et al. Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats. Cancer Res 1994; 54: 33573360.
  • 33
    Dragan YP, Vaughan J, Jordan VC, Pitot HC. Comparison of the effects of tamoxifen and toremifene on liver and kidney tumor promotion in female rats. Carcinogenesis 1995; 16: 27332741.
  • 34
    Kangas L. Review of the pharmacological properties of toremifene. J Steroid Biochem 1990; 36: 191195.
  • 35
    Dombrowski F, Lehringer-Polzin M, Pfeifer U. Hyperproliferative liver acini after intraportal islet transplantation in streptozotocin-induced diabetic rats. Lab Invest 1994; 71: 688699.
  • 36
    Dombrowski F, Bannasch P, Pfeifer U. Hepatocellular neoplasms induced by low-number pancreatic islet transplants in streptozotocin diabetic rats. Am J Pathol 1997; 150: 10711087.
  • 37
    Dombrowski F, Klotz L, Hacker HJ, Li Y, Klingmüller D, Brix K, et al. Hyperproliferative hepatocellular alterations after intraportal transplantation of thyroid follicles. Am J Pathol 2000; 156: 99113.
  • 38
    Dombrowski F, Filsinger E, Bannasch P, Pfeifer U. Altered liver acini induced in diabetic rats by portal vein islet isografts resemble preneoplastic hepatic foci in their enzymic pattern. Am J Pathol 1996; 148: 12491256.
  • 39
    Scharf JG, Ramadori G, Dombrowski F. Analysis of the IGF axis in preneoplastic hepatic foci and hepatocellular neoplasms developing after low-number pancreatic islet transplantation into the livers of streptozotocin diabetic rats. Lab Invest 2000; 80: 13991411.
  • 40
    Evert M, Schneider-Stock R, Dombrowski F. Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat. Lab Invest 2005; 85: 99108.
  • 41
    Evert M, Sun JP, Pichler S, Slavova N, Schneider-Stock R, Dombrowski F. Insulin receptor, insulin receptor substrate-1, Raf-1, and Mek-1 during hormonal hepatocarcinogenesis by intrahepatic pancreatic islet transplantation in diabetic rats. Cancer Res 2004; 64: 80938100.
  • 42
    Dombrowski F, Jost CM, Manekeller S, Evert M. Co-carcinogenic effects of islet hormones and N-nitrosomorpholine in hepatocarcinogenesis after intra-hepatic transplantation of pancreatic islets in streptozotocin-diabetic rats. Cancer Res 2005; 65: 70137022.
  • 43
    Dombrowski F, Mathieu C, Evert M. Hepatocellular neoplasms induced by low-number pancreatic islet transplants in autoimmune diabetic BB/Pfd rats. Cancer Res 2006; 66: 18331843.
  • 44
    Bannasch P, Klimek F, Mayer D. Early bioenergetic changes in hepatocarcinogenesis: preneoplastic phenotypes mimic responses to insulin and thyroid hormone. J Bioenerg Biomembr 1997; 29: 303313.