Liver Biology and Pathobiology
Article first published online: 25 MAY 2006
Copyright © 2006 American Association for the Study of Liver Diseases
Volume 43, Issue 6, pages 1220–1230, June 2006
How to Cite
Liu, Z.-X., Han, D., Gunawan, B. and Kaplowitz, N. (2006), Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology, 43: 1220–1230. doi: 10.1002/hep.21175
See Editorial on Page 1191
Potential conflict of interest: Nothing to report.
- Issue published online: 25 MAY 2006
- Article first published online: 25 MAY 2006
- Manuscript Accepted: 3 MAR 2006
- Manuscript Received: 27 JUL 2005
- Robert E. and May R.Wright Foundation
- NIH. Grant Numbers: DK30312, DK67149
- Garrie-Budnick Foundation
- Los Angeles Chapter of The American Liver Foundation
Supplementary material for this article can be found on the H EPATOLOGY website ( http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html ).
|jws-hep.21175.psd||681K||Supplemental Figure 1.The effect of anti-Gr-1 pretreatment on LPS-induced liver injury and mRNA expreesion for TNFa and CD14. Normal B6 mice with or without pretreatment by anti-Gr-1 antibody (250&#x03bc;g at ?24hr and 150&#x03bc;g at-4hr per mouse,i.p.) were challenged with LPS (1mg/kg, i.p.). A) Serum ALT levels at 2hr and 6hr after LPS challenge; B) mRNA expression for TNFa and CD14 in the liver. Liver tissues were harvested from control mouse and LPS-challenged mice (at 3hr after LPS)with or without pretreatmentby anti-Gr-1 antibody. Total RNA was extracted and analyzed by reverse-transcription PCR|
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