Supplementary material for this article can be found on the H EPATOLOGY website ( )

jws-hep.21241.TIF176K Supplementary Figure 1. Pyrazole-enhanced LPS liver injury in wild type 129Sv mice.Pyrazole (150mg/kg) or saline was injected ip daily for 2 days followed by LPS (4mg/kg) or saline injection ip. Blood and liver samples were collected at 24 h after treatment with LPS or saline, and transaminase levels were assayed as described in MATERIALS AND METHODS. Serum ALT (A) and AST (B): Data are presented as mean?SD (n=6). H&E stained liver sections (C): no changes were observed in saline (a), pyrazole (b), or the LPS groups (c); large necrotic areas were observed in the LPS/pyrazole group (d); almost normal morphology was observed in the LPS/pyrazole plus CMZ group (e). Sal: saline; Py: pyrazole; LPS: lipopolysaccharide; CMZ: chlormethiazole.

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.