Liver biopsy interpretation for causes of late liver allograft dysfunction†
Article first published online: 26 JUL 2006
Copyright © 2006 American Association for the Study of Liver Diseases
Volume 44, Issue 2, pages 489–501, August 2006
How to Cite
Demetris, A. J. (2006), Liver biopsy interpretation for causes of late liver allograft dysfunction. Hepatology, 44: 489–501. doi: 10.1002/hep.21280
Potential conflict of interest: Nothing to report.
See end of article text for complete list of authors and affiliations.
- Issue published online: 26 JUL 2006
- Article first published online: 26 JUL 2006
- Manuscript Accepted: 22 MAY 2006
- Manuscript Received: 12 OCT 2005
- National Institutes of Health. Grant Number: DK49615
Evaluation of needle biopsies and extensive clinicopathological correlation play an important role in the determination of liver allograft dysfunction occurring more than 1 year after transplantation. Interpretation of these biopsies can be quite difficult because of the high incidence of recurrent diseases that show histopathological, clinical, and serological features that overlap with each other and with rejection. Also, more than one insult can contribute to allograft injury. In an attempt to enable centers to compare and pool results, improve therapy, and better understand pathophysiological disease mechanisms, the Banff Working Group on Liver Allograft Pathology herein proposes a set of consensus criteria for the most common and problematic causes of late liver allograft dysfunction, including late-onset acute and chronic rejection, recurrent and new-onset viral and autoimmune hepatitis, biliary strictures, and recurrent primary biliary cirrhosis and primary sclerosing cholangitis. A discussion of differential diagnosis is also presented. (HEPATOLOGY 2006;44:489–501.)