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Liver Biology and Pathobiology
Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob mice†
Article first published online: 29 AUG 2006
Copyright © 2006 American Association for the Study of Liver Diseases
Volume 44, Issue 3, pages 581–591, September 2006
How to Cite
García-Ruiz, I., Rodríguez-Juan, C., Díaz-Sanjuan, T., del Hoyo, P., Colina, F., Muñoz-Yagüe, T. and Solís-Herruzo, J. A. (2006), Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob mice. Hepatology, 44: 581–591. doi: 10.1002/hep.21313
Potential conflict of interest: Nothing to report.
- Issue published online: 29 AUG 2006
- Article first published online: 29 AUG 2006
- Manuscript Accepted: 19 JUN 2006
- Manuscript Received: 15 DEC 2005
- “Fundación Mutua Madrileña”, Madrid, Spain. Grant Number: 012/2005
- “Red Temática de Investigación Cooperativa del Instituto de Salud Carlos III”, Spain. Grant Number: 03/015
Supplementary material for this article can be found on the H EPATOLOGY website ( http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html ).
|jws-hep.21313.fig1.TIF||97K||Mitochondrial respiratory chain (MRC).Mitochondrial -oxidation of fatty acids leads to the formation of short-chain acyl-CoA and acetyl-CoA and the conversion of oxidized nicotinamide adenine dinucleotide (NAD + ) and flavin adenine dinucleotide (FAD) into NADH and FADH 2 . MRC reoxidizes NADH and FADH 2into NAD +and FAD, respectively. Electrons from NADH and FADH 2are transferred to this enzymatic chain, where they are finally combined with oxygen and protons to form water. This transfer of electrons along the MRC is coupled with the exit of protons from the mitochondrial matrix into the intermembrane space creating an electrochemical potential across the inner membrane. Protons return to the matrix through adenosine triphosphate synthase, causing the conversion of adenosine diphosphate (ADP) into adenosine triphosphate (ATP). In normal conditions, a small fraction of electrons flowing along the MRC reacts with oxygen to form ROS. Impaired MRC function results in an increased ROS formation. NADH DH, NADH dehydrogenase. Succ.-DH, succinate dehydrogenase. Cyt. b-c 1 , cytochrome b-c 1 . Cyt. c, cytochrome c. Cyt. a-a 3oxidase, cytochrome oxidase complex. ROS, reactive oxygen species. UQ, ubiquinone.|
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