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Supplementary material for this article can be found on the H EPATOLOGY website ( http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html ).

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jws-hep.21314.tif173KThe effect of MMP-9 on liver regeneration is shown with the effect being either direct or through the remodeling of the extracellular matrix (ECM). Solid lines indicate data shown in the MMP-9 -/-model. Dashed lines indicate effects reported in the literature but not shownin vivoin our model of partial hepatectomy.

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