fax: 216-844-8011
Viral Hepatitis
You have full text access to this OnlineOpen article
Cost-effectiveness of hematologic growth factors for anemia occurring during hepatitis C combination therapy†‡
Article first published online: 28 NOV 2006
DOI: 10.1002/hep.21409
Copyright © 2006 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Del Rio, R. A., Post, A. B. and Singer, M. E. (2006), Cost-effectiveness of hematologic growth factors for anemia occurring during hepatitis C combination therapy. Hepatology, 44: 1598–1606. doi: 10.1002/hep.21409
- †
See Editorial on Page 1400
- ‡
Potential conflict of interest: Dr. Post owns stock in Amgen. He is on the speakers' bureau for Schering-Plough, Roche, and Valeant.
Publication History
- Issue published online: 28 NOV 2006
- Article first published online: 28 NOV 2006
- Manuscript Accepted: 29 AUG 2006
- Manuscript Received: 21 OCT 2005
References
- 1, . American Gastroenterological Association technical review on the management of hepatitis C. Gastroenterology 2006; 130: 231–264.
- 2, , , , . Survival after liver transplantation in the United States: a disease-specific analysis of the UNOS database. Liver Transpl 2004; 10: 886–897.Direct Link:
- 3, , , , , , et al. Peginterferon alfa-2b plus ribavirin compared to interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958–965.
- 4, , , , , , et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975–982.
- 5. Safety of combination interferon alfa-2b/ribavirin therapy in chronic hepatitis C-relapsed and treatment-naive patients. Semin Liver Dis 1999; 19( Suppl 1): 67–75.
- 6Rebetol (ribavirin, USP) product information. Kenilworth, NJ: Schering Corporation, 2003. [Package insert.]
- 7, , , , , , et al. Rapid suppression of hematopoiesis by standard or pegylated interferon-alpha. Gastroenterology 2002; 123: 141–151.
- 8, , , , . Erythropoietin response to anemia is decreased in patients infected with hepatitis C virus (HCV) receiving combination therapy and pegylated interferon (RBV/PEG-IFN) therapy [Abstract]. Gastroenterology 2003; 124: M1417.
- 9, , , , , , et al. Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C. Gastroenterology 2002; 123: 1061–1069.
- 10, , , , , , et al. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med 2004; 140: 346–355.
- 11, , , , . A preliminary study of erythropoietin for anemia associated with ribavirin and interferon-alpha. Am J Gastroenterol 2001; 96: 2802–2804.
- 12, , , . Treatment of ribavirin/interferon-induced anemia with erythropoietin in patients with hepatitis C. HEPATOLOGY 2002; 35: 1281–1282.Direct Link:
- 13, , , , , , et al. Once-weekly epoetin alfa improves anemia and facilitates maintenance of ribavirin dosing in hepatitis C virus-infected patients receiving ribavirin plus interferon alfa. Am J Gastroenterol 2003; 98: 2491–2499.
- 14, , , , , , et al. Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study. Gastroenterology 2004; 126: 1302–1311.
- 15, , , , , , et al. Darbepoetin alpha (DA) for ribavirin-induced anemia in patients with chronic hepatitis C (CH-C) treated with pegylated interferon and ribavirin (PEG-IFN/RBV): a preliminary analysis [Abstract]. Gastroenterology 2004; 126( Suppl 1): 83A.
- 16. Role of epoetin alpha in maintaining ribavirin dose. Gastroenterol Clin N Am 2004; 33: S25–S35.
- 17. Epoetin alfa treatment for acute anaemia during interferon plus ribavirin combination therapy for chronic hepatitis C. J Viral Hepat 2004; 11: 191–197.Direct Link:
- 18, , . Current status of the use of growth factors and other adjuvant medications in patients receiving peginterferon and ribavirin. Rev Gastroenterol Disord 2004; 4( Suppl 1): S39–S47.
- 19CohenHE, editor. Drug Topics. Red Book. Montvale, NJ: Thomson PDR, 2005.
- 20, , , . Cost-effectiveness in Health and Medicine. New York: Oxford University Press, 1996.
- 21. Meta-analysis, Decision Analysis and Cost-effectiveness Analysis. New York: Oxford University Press, 1994.
- 22, , , , , . Early virologic response to treatment with peginterferon alpha-2b plus ribavirin in patients with chronic hepatitis C. HEPATOLOGY 2003; 38: 645–652.Direct Link:
- 23, , , . Cost effectiveness of interferon alpha2b combined with ribavirin for the treatment of chronic hepatitis C. HEPATOLOGY 1999; 30: 1318–1324.Direct Link:
- 24, , , , , , et al. The long-term pathological evolution of chronic hepatitis C. HEPATOLOGY 1996; 23: 1334–1340.Direct Link:
- 25, , , , , , et al. Long-term mortality after transfusion-associated non-A, non-B hepatitis. The National Heart, Lung, and Blood Institute Study Group. N Engl J Med 1992; 327: 1906–1911.
- 26, , , , , . Changes in liver histopathology in women infected with hepatitis C through contaminated anti-D immunoglobulin injections in Ireland. Eur J Gastroenterol Hepatol 1998; 10: 69–73.
- 27, , , , , . Assessment of long-term outcomes of community-acquired hepatitis C infection in a cohort with sera stored from 1971 to 1975. HEPATOLOGY 2000; 32: 582–587.Direct Link:
- 28, , , , , , et al. 45-Year follow-up of hepatitis C virus infection in healthy young adults. Ann Intern Med 2000; 132: 105–111.
- 29, , , , , , et al. Cost-effectiveness of 6 and 12 months of interferon-alpha therapy for chronic hepatitis C. Ann Intern Med 1997; 127: 866–874.
- 30, , , , , , et al. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology 1997; 112: 463–472.
- 31, , , , , , et al. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 1993; 328: 1797–1801.
- 32, , , , , , et al. Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med 1991; 325: 675–680.
- 33, , , , , . Estimates of the cost-effectiveness of a single course of interferon-alpha 2b in patients with histologically mild chronic hepatitis C. Ann Intern Med 1997; 127: 855–865.
- 34, , , , . Estimating the prognosis of hepatitis C patients infected by transfusion in Canada between 1986 and 1990. Med Decis Making 2004; 24: 20–29.
- 35, , , . Liver transplantation for hepatitis C virus-related cirrhosis. HEPATOLOGY 1994; 20: 24S–27S.
- 36, , . Liver transplantation for chronic viral hepatitis. Viral Hepatitis Rev 1996; 2: 219–228.
- 37, , . An analysis of liver transplant experience from 37 transplant centers as reported to Medicare. Transplantation 1993; 56: 554–561.
- 38National Institutes of Health Consensus Development Conference Statement: management of hepatitis C: 2002—June 10–12, 2002. HEPATOLOGY 2002; 36: S3–S20.Direct Link:
- 39, , , , , , et al. Health-state utilities and quality of life in hepatitis C patients. Am J Gastroenterol 2003; 98: 630–638.Direct Link:
- 40, , , , . The cost-effectiveness of maintaining higher hemoglobin targets with erythropoietin in hemodialysis patients. Kidney International 2003; 64: 295–304.
- 41, , . Cost-effectiveness of recombinant human erythropoietin in the prevention of chemotherapy-induced anaemia. Br J Cancer 1998; 78: 781–787.
- 42, . Cost effectiveness of screening for hepatitis C virus in asymptomatic, average-risk adults. Am J Med 2001; 111: 614–621.
- 43, , , , . Assessment of utilities and health-related quality of life in patients with chronic liver disease. Am J Gastroenterol 2001; 96: 579–583.Direct Link:
- 44, , , . Health values of patients with chronic hepatitis C infection. Arch Intern Med 2004; 164: 2377–2382.
- 45, , . Comparison of health-related quality of life preferences between physicians and cirrhotic patients: implications for cost-utility analyses in chronic liver disease. Dig Dis Sci 2004; 49: 453–458.
- 46. Handling uncertainty in cost-effectiveness models. Pharmacoeconomics 2000; 17: 479–500.
- 47, , , . Cost-effectiveness of treatment for chronic hepatitis C infection in an evolving patient population. JAMA 2003; 290: 228–237.
- 48, , , , , , et al. Cost effectiveness of peginterferon alpha-2a plus ribavirin versus interferon alpha-2b plus ribavirin as initial therapy for treatment-naive chronic hepatitis C. Pharmacoeconomics 2004; 22: 257–265.
- 49, , , . Pretreatment evaluation of chronic hepatitis C: risks, benefits, and costs. JAMA 1998; 280: 2088–2093.
- 50, , , , , , et al. Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment. Gastroenterology 2004; 126: 1015–1023 [discussion: 1947].

1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
1527-3350/asset/cover.gif?v=1&s=3cd983af6575c8dbfd6b47a63ffa95415ace15f8)