• 1
    Slehria S, Rajvanshi P, Ito Y, Sokhi R, Bhargava KK, Palestro CJ, et al. Hepatic sinusoidal vasodilators improve transplanted cell engraftment and ameliorate microcirculatory perturbations in the liver. HEPATOLOGY 2002; 35: 13201328.
  • 2
    Malhi H, Annamaneni P, Slehria S, Joseph B, Bhargava KK, Palestro CJ, et al. Cyclophosphamide disrupts hepatic sinusoidal endothelium and improves transplanted cell engraftment in rat liver. HEPATOLOGY 2002; 36: 112121.
  • 3
    Joseph B, Malhi H, Bhargava KK, Palestro CJ, McCuskey RS, Gupta S. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology 2002; 123: 16771685.
  • 4
    Kim KS, Joseph B, Inada M, Gupta S. Regulation of hepatocyte engraftment and proliferation after cytotoxic drug-induced perturbation of the rat liver. Transplantation 2005; 80: 653659.
  • 5
    Benten D, Kumaran V, Joseph B, Gupta S. Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment. HEPATOLOGY 2005; 42: 10721081.
  • 6
    Kumaran V, Joseph B, Benten D, Gupta S. Integrin and extracellular matrix interactions regulate engraftment of transplanted hepatocytes in the rat liver. Gastroenterology 2005; 129: 16431653.
  • 7
    Laconi E, Oren R, Mukhopahyay DK, Hurston E, Laconi S, Pani P, et al. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol 1998; 153: 319329.
  • 8
    Guha C, Sharma A, Gupta S, Alfieri A, Gorla GR, Gagandeep S, et al. Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation. Cancer Res 1999; 59: 58715874.
  • 9
    De Vree JM, Ottenhoff R, Bosma PJ, Smith AJ, Aten J, Oude Elferink RP. Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis. Gastroenterology 2000; 119: 17201730.
  • 10
    Mallet VO, Mitchell C, Guidotti JE, Jaffray P, Fabre M, Spencer D, et al. Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice. Nat Biotechnol 2002; 20: 12341239.
  • 11
    Malhi H, Gorla GR, Irani AN, Annamaneni P, Gupta S. Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulation. Proc Natl Acad Sci U S A 2002; 99: 1311413119.
  • 12
    Shah M, Patel K, Sehgal PB. Monocrotaline pyrrole-induced endothelial cell megalocytosis involves a Golgi blockade mechanism. Am J Physiol Cell Physiol 2005; 288: C850C862.
  • 13
    DeLeve LD, McCuskey RS, Wang X, Hu L, McCuskey MK, Epstein RB, et al. Characterization of a reproducible rat model of hepatic veno-occlusive disease. HEPATOLOGY 1999; 29: 17791791.
  • 14
    Kono H, Fujii H, Asakawa M, Yamamoto M, Maki A, Matsuda M, et al. Functional heterogeneity of the kupffer cell population is involved in the mechanism of gadolinium chloride in rats administered endotoxin. J Surg Res 2002; 106: 179187.
  • 15
    Copple BL, Rondelli CM, Maddox JF, Hoglen NC, Ganey PE, Roth RA. Modes of cell death in rat liver after monocrotaline exposure. Toxicol Sci 2004; 77: 172182.
  • 16
    Wang YP, Yan J, Beger RD, Fu PP, Chou MW. Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo. Cancer Lett 2005; 226: 2735.
  • 17
    Gorla GR, Malhi H, Gupta S. Polyploidy associated with oxidative DNA injury attenuates proliferative potential of cells. J Cell Sci 2001; 114: 29432951.
  • 18
    Witek RP, Fisher SH, Petersen BE. Monocrotaline, an alternative to retrorsine-based hepatocyte transplantation in rodents. Cell Transplant 2005; 14: 4147.
  • 19
    Gupta S, Rajvanshi P, Lee C-D. Integration of transplanted hepatocytes in host liver plates demonstrated with dipeptidyl peptidase IV deficient rats. Proc Natl Acad Sci USA 1995; 92: 58605864.
  • 20
    Gupta S, Rajvanshi P, Malhi H, Sokhi RP, Slehria S, Vasa SRG, et al. Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver. Am J Physiol Gastroint Liver Physiol 2000; 279: G815G826.
  • 21
    Deaciuc IV, Bagby GJ, Lang CH, Spitzer JJ. Hyaluronic acid uptake by the isolated, perfused rat liver: an index of hepatic sinusoidal endothelial cell function. HEPATOLOGY 1992; 17: 262272.
  • 22
    Joseph B, Bhargava KK, Trunco G, Kumaran V, Palestro CJ, Gupta S. Regulation of hepatobiliary transport activity and noninvasive identification of cytokine-dependent liver inflammation. J Nucl Med 2005; 46: 146152.
  • 23
    Gupta S, Rajvanshi P, Aragona E, Yerneni PR, Lee C-D, Burk RD. Transplanted hepatocytes proliferate differently after CCl4 treatment and hepatocyte growth factor infusion. Am J Physiol 1999; 276: G629G638.
  • 24
    Gupta S, Rajvanshi P, Sokhi RP, Slehria S, Yam A, Kerr A, et al. Entry and integration of transplanted hepatocytes in liver plates occur by disruption of hepatic sinusoidal endothelium. HEPATOLOGY 1999; 29: 509519.
  • 25
    Reid MJ, Lame MW, Morin D, Wilson DW, Segall HJ. Involvement of cytochrome P450 3A in the metabolism and covalent binding of 14C-monocrotaline in rat liver microsomes. J Biochem Mol Toxicol 1998; 12: 157166.
  • 26
    Gordon GJ, Coleman WB, Grisham JW. Temporal analysis of hepatocyte differentiation by small hepatocyte-like progenitor cells during liver regeneration in retrorsine-exposed rats. Am J Pathol 2000; 157: 771786.
  • 27
    Wang X, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M. The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci U S A 2003; 100( Suppl 1): 1188111888.
  • 28
    Menthena A, Deb N, Oertel M, Grozdanov PN, Sandhu J, Shah S, et al. Bone marrow progenitors are not the source of expanding oval cells in injured liver. Stem Cells 2004; 22: 10491061.
  • 29
    Gordon GJ, Butts GM, Grisham JW, Coleman WB. Isolation, short-term culture, and transplantation of small hepatocyte-like progenitor cells from retrorsine-exposed rats. Transplantation 2002; 73: 12361243.
  • 30
    Shumaker RC, Robertson KA, Hsu IC, Allen JR. Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine. J Natl Cancer Inst 1976; 56: 787790.
  • 31
    Copple BL, Ganey PE, Roth RA. Liver inflammation during monocrotaline hepatotoxicity. Toxicology 2003; 190: 155169.
  • 32
    Laconi S, Pillai S, Porcu PP, Shafritz DA, Pani P, Laconi E. Massive liver replacement by transplanted hepatocytes in the absence of exogenous growth stimuli in rats treated with retrorsine. Am J Pathol 2001; 158: 771777.
  • 33
    Wu YM, Joseph B, Gupta S. Immunosuppression using the mTOR inhibition mechanism affects replacement of the rat liver with transplanted cells. HEPATOLOGY 2006; 44: 410419.