These authors contributed equally to this work.
Role of caspase-8 in hepatocyte response to infection and injury in mice†
Article first published online: 23 MAR 2007
Copyright © 2006 American Association for the Study of Liver Diseases
Volume 45, Issue 4, pages 1014–1024, April 2007
How to Cite
Ben Moshe, T., Barash, H., Kang, T.-B., Kim, J.-C., Kovalenko, A., Gross, E., Schuchmann, M., Abramovitch, R., Galun, E. and Wallach, D. (2007), Role of caspase-8 in hepatocyte response to infection and injury in mice. Hepatology, 45: 1014–1024. doi: 10.1002/hep.21495
Potential conflict of interest: Nothing to report.
- Issue published online: 28 MAR 2007
- Article first published online: 23 MAR 2007
- Manuscript Accepted: 1 NOV 2006
- Manuscript Received: 30 MAY 2006
- Ares Trading SA, Switzerland
- Center of Excellence Grant from the Flight Attendant Medical Research Institute (FAMRI)
- Joseph and Bessie Feinberg Foundation
- Yeshaya Horowitz Association through The Center for Complexity Science
- Israel Science Foundation. Grant Number: 728/05
- Israel Ministry of Science, through a grant given to the National Gene Therapy Knowledge Center and through EC grants. Grant Numbers: LSHB-CT-2004-512034, LSHB-CT-2005-018961
- Harold Grinspoon
- Wolfson Foundations
Supplementary material for this article can be found on the H EPATOLOGY website ( http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html ).
|jws-hep.21495.fig1.pdf||306K||Supplementary Fig. 1: Histological analysis of the ischemic area of a mouse liver 2 days after PHx (A)H&E-stained section of the ischemic area of the liver of aCasp8 F+: :Alb-Cremouse 2 days after PHx. A large focus of ghost cells and necrosis (N) of the hepatic parenchyma can be seen in the operated area. Suture material (S) is seen within the necrotic area. The necrotic parenchyma is surrounded by a rim of infiltrating leukocytes (I).(B)TUNEL staining of the area shown in the inset from (A), demonstrating massive apoptosis in this area (red staining indicates TUNEL-positive nuclei in the wounded liver parenchyma). Above this region are dead and ghost cells (no staining), while below there are living cells with DAPI-stained nuclei.(C)Anti active caspase-3 immunostaining of hepatocytes located at the rim of the wounded hepatic parenchyma. Both the cytoplasm and the nuclei are stained. Magnification: A, ×20; B, ×100; C: ×400.|
|jws-hep.21495.doc||1096K||Supporting Information file jws-hep.21495.doc|
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