fax: 507-266-4531
Original Article
You have full text access to this OnlineOpen article
The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD†
Article first published online: 28 MAR 2007
DOI: 10.1002/hep.21496
Copyright © 2007 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Angulo, P., Hui, J. M., Marchesini, G., Bugianesi, E., George, J., Farrell, G. C., Enders, F., Saksena, S., Burt, A. D., Bida, J. P., Lindor, K., Sanderson, S. O., Lenzi, M., Adams, L. A., Kench, J., Therneau, T. M. and Day, C. P. (2007), The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology, 45: 846–854. doi: 10.1002/hep.21496
- †
Potential conflict of interest: Nothing to report.
Publication History
- Issue published online: 28 MAR 2007
- Article first published online: 28 MAR 2007
- Manuscript Accepted: 2 NOV 2006
- Manuscript Received: 19 MAY 2006
References
- 1, , , , , , et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. HEPATOLOGY 2004; 40: 1387–1395.Direct Link:
- 2, , , , , . Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study. HEPATOLOGY 2005; 42: 44–52.Direct Link:
- 3, , , , , , et al. Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J Hepatol 2005; 43: 508–514.
- 4, , , , , . Prevalence of fatty liver in a general population of Okinawa, Japan. Jpn J Med 1988; 27: 142–149.
- 5, , , , , . Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. HEPATOLOGY 1999; 29: 664–669.Direct Link:
- 6, , , , , , et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002; 123: 134–140.
- 7, , , , , , et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005; 129: 113–121.
- 8, , , , , , et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. HEPATOLOGY 2006; 43: 682–689.Direct Link:
- 9, , , , . The natural history of nonalcoholic fatty liver: a follow-up study. HEPATOLOGY 1995; 22: 1714–1719.Direct Link:
- 10, , , , , , et al. Long term prognosis of fatty liver: risk of chronic liver disease and death. Gut 2004; 53: 750–755.
- 11, , . Prevalence and indicators of portal hypertension in nonalcoholic fatty liver disease. Gastroenterology 2004; 126: A759.
- 12, , , , , . Non alcoholic fatty liver disease: A spectrum of clinical and pathological severity. Gastroenterology 1999; 116: 1413–1419.
- 13, , , , , , et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. HEPATOLOGY 2006; 44: 865–873.Direct Link:
- 14, , , , , , et al. Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C. HEPATOLOGY 2003; 38: 420–427.Direct Link:
- 15, , , . Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. HEPATOLOGY 1999; 30: 1356–1362.Direct Link:
- 16, , , , , , et al. Liver fibrosis in overweight patients. Gastroenterology. 2000; 118: 1117–1123.
- 17, , . Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001; 121: 91–100.
- 18, , , , . Nonalcoholic steatohepatitis: risk factors for liver fibrosis. J Hepatol 2002; 24: 429–438.
- 19, , , , , , et al. Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology 2004; 127: 1704–1713.
- 20, , , , , , et al. Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease. World J Gastroenterol 2005; 11: 255–259.
- 21, , , , , , et al. Serum YKL-40 is increased in patients with hepatic fibrosis. J Hepatol 2000; 32: 911–920.
- 22, , , , , , et al. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. BMC Gastroenterology 2006; 6: 6.
- 23, , , , , . Homeostatic model assessment: insulin resistance and beta-cell function from fasting glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–419.
- 24, , , , , , et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. HEPATOLOGY 2003; 38: 518–526.Direct Link:
- 25, , , , , , et al. Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. HEPATOLOGY 2005; 41: 1313–1321.Direct Link:
- 26, , , , , , et al. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C. HEPATOLOGY 2005; 41: 48–54.Direct Link:
- 27, , , , , , et al. Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology 2005; 128: 343–350.
- 28, , , , , , et al. Prevalence and factors associated with failure of liver stiffness measurement using FibroScan in a prospective study of 2114 examinations. Eur J Gastroenterol Hepatol 2006; 18: 411–412.
- 29, , , , , , et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 2005; 128: 1898–1906.
- 30, , , , , , et al. Source of variability in histological scoring of chronic viral hepatitis. HEPATOLOGY 2005; 41: 257–264.Direct Link:

1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
