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AASLD Practice Guidelines
Article first published online: 26 JAN 2007
DOI: 10.1002/hep.21513
Copyright © 2007 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Lok, A. S. F. and McMahon, B. J. (2007), Chronic hepatitis B. Hepatology, 45: 507–539. doi: 10.1002/hep.21513
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Potential conflict of interest: Dr. McMahon's spouse owns stock in GlaxoSmithKline. Dr. Lok is a consultant for, received grants, and is on the Scientific Advisory Board of, Bristol-Myers Squibb, GlaxoSmithKline, Idenix, Roche, Gilead, and Innogenetics. She is also on the Scientific Advisory Board of Pharmasset. Dr. Lok received grants from Schering-Plough.
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Please refer to www.aasld.org for disclosures by Practice Guidelines Committee members.All AASLD Practice Guidelines are updated annually. If you are viewing a Practice Guideline that is more than 12 months old, please visit www.aasld.org for an update in the material.
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Publication History
- Issue published online: 26 JAN 2007
- Article first published online: 26 JAN 2007
REFERENCES
- 1. A Manual for Assessing Health Practices and Designing Practice Guidelines. Philadelphia. American College of Physicians, 1996: 1–126.
- 2American Gastroenterological Association policy statement on the use of medical practice guidelines by managed care organizations and insurance carriers. Gastroenterology 1995; 108: 925–926.
- 3, , . Management of hepatitis B: 2000—summary of a workshop. Gastroenterology 2001; 120: 1828–1853.
- 4, , , , . Management of Hepatitis B: Summary of a Clinical Research Workshop. HEPATOLOGY (submitted).
- 5
- 6, , , , , , et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2005 update. Liver Int 2005; 25: 472–489.
- 7. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004; 11: 97–107.
- 8, , , , , . Prevalence of hepatitis B virus infection in the United States: the National Health and Nutrition Examination Surveys, 1976 through 1994. [see comments]. Am J Public Health 1999; 89: 14–18.
- 9, , , , , , et al. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: immunization of infants, children, and adolescents. MMWR Recomm Rep 2005; 54: 1–31.
- 9a, , , , , , et al. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States—Mrecommendations of the Advisory Committee on Immunization Practices (ACIP) Part II: Immunization of adults. MMWR 2006; 55(RR-16): 1–33.
- 10. Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 1988; 61: 1942–1956.
- 11, , , . Epidemiology of hepatocellular carcinoma. Clin Liver Dis 2005; 9: 191–211, v.
- 12, , . Management of the hepatitis B virus in the liver transplantation setting: a European and an American perspective. Liver Transpl 2005; 11: 716–732.
- 13. Epidemiology and natural history of hepatitis B. Semin Liver Dis 2005; 25(Suppl 1): 3–8.
- 14, , . Strategies to prevent and control hepatitis B and C virus infections: a global perspective. Vaccine 1999; 17: 1730–1733.
- 15, , , , , . Survival of hepatitis B virus after drying and storage for one week. Lancet 1981; 1: 550–551.
- 16, , , , , , . Hepatitis B surface antigen in saliva, impetiginous lesions, and the environment in two remote Alaskan villages. Appl Environ Microbiol 1976; 32: 572–574.
- 17, , , , , , et al. Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine. Lancet 1983; 2: 1099–1102.
- 18, , , , , , et al. Incidence of hepatitis B virus infections in preschool children in Taiwan. J Infect Dis 1982; 146: 198–204.
- 19, , , , , , et al. Age- and sex-related study of hepatitis B virus chronic carrier state in infants from an endemic area (Senegal). J Med Virol 1987; 22: 1–5.
- 20, , , , , , et al. Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state. J Infect Diseases 1985; 151: 599–603.
- 21, , , , , . Natural history of acute hepatitis B surface antigen-positive hepatitis in Greek adults. Gastroenterology 1987; 92: 1844–1850.
- 22, . Clinical aspects of the interactions between human immunodeficiency virus and the hepatotropic viruses. Clin Infect Dis 1994; 18: 339–347.
- 23, , . The effect of concurrent human immunodeficiency virus infection on chronic hepatitis B: a study of 150 homosexual men. J Infect Dis 1989; 160: 577–582.
- 24, , , , , , et al. Isolated antibody to hepatitis B core antigen in human immunodeficiency virus type-1-infected individuals. Clin Infect Dis 2003; 36: 1602–1605.
- 25, , . Prevalence of isolated antibody to hepatitis B core antigen in an area endemic for hepatitis B virus infection: implications in hepatitis B vaccination programs. HEPATOLOGY 1988; 8: 766–770.
- 26, . Clinical significance and management when antibody to hepatitis B core antigen is the sole marker for HBV infection. Viral Hep Rev 2000; 6: 229–236.
- 27, , , , , , et al. Susceptiblility of chronic symptomless HBsAg carriers to ethanol-induced hepatic damage. Lancet 1982: 1243–1245.
- 28, , , , , . Interaction between hepatitis B virus and alcohol consumption in liver cirrhosis: An epidemiologic study. Gastroenterology 1983: 141–145.
- 29, , , , , , et al. Prevention of the HBsAg carrier state in newborn infants of mothers who are chronic carriers of HBsAg and HBeAg by administration of hepatitis-B vaccine and hepatitis-B immunoglobulin. Double-blind randomised placebo-controlled study. Lancet 1984; 1: 921–926.
- 30, , , , , , et al. Transmission of hepatitis B virus to multiple patients from a surgeon without evidence of inadequate infection control. [see comments]. N Engl J Med 1996; 334: 549–554.
- 31. The infected health care provider. [letter; comment]. [see comments]. N Engl J Med 1996; 334: 594–595.
- 32CDC. Recommendations for preventing transmission of human immunodeficiency virus and hepatitis B virus to patients during exposure-prone invasive procedures. MMWR 1991; 40: 1–7.
- 33, , , , , , et al. Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in health care workers (HCWs): guidelines for prevention of transmission of HBV and HCV from HCW to patients. J Clin Virol 2003; 27: 213–230.
- 34, , . Doctor to patient transmission of hepatitis B virus: implications of HBV DNA levels and potential new solutions. Antiviral Res 2003; 60: 79–85.
- 35, , , , , , et al. The risk of transmission of hepatitis B from HBsAg(−), HBcAb(+), HBIgM(−) organ donors. Transplantation 1995; 59: 230–234.
- 36, , , , , , et al. Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. The National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database. Gastroenterology 1997; 113: 1668–1674.
- 37, , , , , , et al. De novo hepatitis B after liver transplantation from hepatitis B core antibody-positive donors in an area with high prevalence of anti-HBc positivity in the donor population. Liver Transpl 2001; 7: 51–58.
- 38. Review article: hepatitis B and liver transplantation. Aliment Pharmacol Ther 2006; 23: 1031–1041.
- 39, . Hepatitis B virus genotypes: do they play a role in the outcome of HBV infection? HEPATOLOGY 2004; 40: 790–792.
- 40, , , , , , et al. Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes, and HBsAg subtypes. Intervirology 2004; 47: 289–309.
- 41, , , , , , et al. Hepatitis B virus genotypes in the United States: results of a nationwide study. Gastroenterology 2003; 125: 444–451.
- 42, , , , , , et al. Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma. Gut 2004; 53: 1494–1498.
- 43, , . Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C. Gastroenterology 2002; 122: 1756–1762.
- 44, , , . Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000; 118: 554–559.
- 45, . Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline. J Hepatol 2005; 43: 411–417.
- 46, , , , , , et al. Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease. HEPATOLOGY 2003; 37: 19–26.
- 47, , , , , , et al. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. J Natl Cancer Inst 2005; 97: 265–272.
- 48, , , , . Hepatitis B genotypes and the response to interferon therapy. J Hepatol 2000; 33: 998–1002.
- 49, , , . HBV genotype B is associated with better response to interferon therapy in HBeAg(+) chronic hepatitis than genotype C. HEPATOLOGY 2002; 36: 1425–1430.
- 50, , , , , , et al. Response to interferon alfa is hepatitis B virus genotype dependent: genotype A is more sensitive to interferon than gentoype D. Gut 2005; 54: 1009–1013.
- 51, , , , , , et al. Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial. Lancet 2005; 365: 123–129.
- 52, , , , , , et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B. N Engl J Med 2005; 352: 2682–2695.
- 53, , , , , . Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis. Ann Intern Med 1981; 94: 744–748.
- 54, , , , , . Clinical and histological events preceding hepatitis B e antigen seroconversion in chronic type B hepatitis. Gastroenterology 1983; 84: 216–219.
- 55, , , , , , et al. Clinical, virologic and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B. HEPATOLOGY 1986; 6: 167–172.
- 56, , , , . Spontaneous hepatitis B e antigen to antibody seroconversion and reversion in Chinese patients with chronic hepatitis B virus infection. Gastroenterology 1987; 92: 1839–1843.
- 57, . A longitudinal follow-up of asymptomatic hepatitis B surface antigen-positive Chinese children. HEPATOLOGY 1988; 8: 1130–1133.
- 58, , , , , . The significance of spontaneous hepatitis B e antigen seroconversion in childhood: with special emphasis on the clearance of hepatitis B e antigen before 3 years of age. HEPATOLOGY 1995; 22: 1387–1392.
- 59, , , , , , et al. Changes of serum hepatitis B virus DNA and aminotransferase levels during the course of chronic hepatitis B virus infection in children. HEPATOLOGY 1990; 12: 657–660.
- 60, . Acute exacerbations in Chinese patients with chronic hepatitis B virus (HBV) infection. Incidence, predisposing factors and etiology. J Hepatol 1990; 10: 29–34.
- 61, , , , . Regional prevalence of hepatitis B, delta, and human immunodeficiency virus infection in southern Africa: a large population survey. Am J Epidemiol 1989; 129: 138–145.
- 62, , , , , , et al. Chronic hepatitis B in children after e antigen seroclearance: final report of a 29-year longitudinal study. HEPATOLOGY 2006; 43: 556–562.
- 63, , , , , , et al. Clinical and histological outcome after hepatitis B e antigen to antibody seroconversion in children with chronic hepatitis B. HEPATOLOGY 1999: 572–575.
- 64, , , , , , et al. The impact of the hepatitis B mass immunisation campaign on the incidence and risk factors of acute hepatitis B in Italy. J Hepatol 2000; 33: 980–985.
- 65, , , . Serologic and clinical outcomes 1536 Alaska Natives chronically infected with hepatitis B virus. Ann Intern Med 2001: 759–768.
- 66, , , , , , et al. Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men. Hepatology 1999: 1306–1310.
- 67, , , , , , et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. HEPATOLOGY 2002; 35: 1522–1527.
- 68, , . Spontaneous reactivation of chronic hepatitis B virus infection. Gastroenterology 1984; 86: 230–235.
- 69, , , , , , et al. Occurrence of hepatocellular carcinoma and decompensation in western European patients with cirrhosis type B. The EUROHEP Study Group on Hepatitis B Virus and Cirrhosis. HEPATOLOGY 1995; 21: 77–82.
- 70, , , , , , et al. Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B. [see comments]. New Engl J Med 1996; 334: 1422–1427.
- 71, , , , , . Survival and prognostic indicators in hepatitis B surface antigen-positive cirrhosis of the liver. [see comments]. Gastroenterology 1992; 103: 1630–1635.
- 72, , , , , , et al. Prospective study of hepatocellular carcinoma and liver cirrhosis in asymptomatic chronic hepatitis B virus carriers. Am J Epidemiol 1997; 145: 1039–1047.
- 73, , , , , , et al. Natural history and prognostic factors for chronic hepatitis type B. Gut 1991; 32: 294–298.
- 74, , , , . Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa. European Concerted Action on Viral Hepatitis (EUROHEP). HEPATOLOGY 1997; 26: 1338–1342.
- 75, , , , . Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection. HEPATOLOGY 1999; 29: 971–975.
- 76, , , , , , et al. Long-term follow-up of patients with chronic hepatitis B treated with interferon alfa. Gastroenterology 1997; 113: 1660–1667.
- 77, , , , , , et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med 2004; 351: 1521–1531.
- 78, . Hepatitis B e antigen-negative chronic hepatitis B. HEPATOLOGY 2001; 34: 617–624.
- 79, , , , . Hepatitis B e antigen-negative chronic hepatitis B in Hong Kong. HEPATOLOGY 2000; 31: 763–768.
- 80, , . Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus—large-scale analysis using a new genotyping method. J Infect Dis 1997; 175: 1285–1293.
- 81, , , , , . Precore mutant hepatitis B virus infection and liver disease. Gastroenterology 1992: 538–543.
- 82, , , , , , et al. Rapid detection of genotypes and mutations in the pre-core promoter and the pre-core region of hepatitis B virus genome: correlation with viral persistence and disease severity. J Hepatol 2000; 33: 430–439.
- 83, , , , , , et al. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci U S A 1991; 88: 4186–4190.
- 84, , . Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Acad Sci U S A 1994; 91: 4077–4081.
- 85, , , , , , et al. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol 1994; 68: 8102–8110.
- 86, , , , , , et al. Outcome of anti-HBe positive chronic hepatitis B in alpha-interferon treated and untreated patients: a long term cohort study. J Hepatol 2002; 36: 263–270.
- 87, , , , . Incidence, determinants and significance of delayed clearance of serum HBsAg in chronic hepatitis B virus infection: a prospective study. HEPATOLOGY 1991; 13: 627–631.
- 88, , , , , , et al. Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance. J Hepatol 2005; 42: 188–194.
- 89, , , . Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection. Gastroenterology 2002; 123: 1084–1089.
- 90, , , , , , et al. HBsAg seroclearance in chronic hepatitis B in the Chinese: virological, histological, and clinical aspects. HEPATOLOGY 2004; 39: 1694–1701.
- 91, , , , , , et al. Sero-clearance of hepatitis B surface antigen in chronic carriers does not necessarily imply a good prognosis. [see comments]. HEPATOLOGY 1998; 28: 231–236.
- 92, . Natural history of chronic hepatitis B virus infection: what we knew in 1981 and what we know in 2005. HEPATOLOGY 2006; 43: S173–181.
- 93. Natural history and prognosis of hepatitis B. Semin Liver Dis 2003; 23: 47–58.
- 94, , , , , , et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. New Engl Jo Med 2002; 347: 168–174.
- 95, , , , , . Spontaneous clearance of high-titer serum HBV DNA and risk of hepatocellular carcinoma in a Chinese population. Cancer Causes Control 2003; 14: 995–1000.
- 96, , , , , . Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006; 130: 678–686.
- 97, , , , , , et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006; 295: 65–73.
- 98. Understudied populations with hepatitis C. HEPATOLOGY 2002; 36(Suppl): S226–S236.
- 99, , , , , , et al. Effect of concurrent acute infection with hepatitis C virus on acute hepatitis B virus infection. [see comments]. BMJ 1993; 307: 1095–1097.
- 100, , , , , , et al. Displacement of hepatitis B virus by hepatitis C virus as the cause of continuing chronic hepatitis. Gastroenterology 1994; 106: 1048–1053.
- 101, , . Fulminant hepatic failure in acute hepatitis C: increased risk in chronic carriers of hepatitis B virus. Gut 1999; 45: 613–617.
- 102, , , , , . Impact of acute hepatitis C virus superinfection in patients with chronic hepatitis B virus infection. Gastroenterology 2004; 126: 1024–1029.
- 103, , . A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma. Int J Cancer 1998; 75: 347–354.
- 104
- 105, , , , , , et al. Chronic hepatitis D: a vanishing Disease? An Italian multicenter study. HEPATOLOGY 2000; 32: 824–827.
- 106, , , , , , et al. Hepatitis B virus-associated coinfection and superinfection with delta agent: Indistinguishable disease with different outcome. J Infect Dis 1985: 925–928.
- 107, , , , , , et al. Influence of hepatitis delta virus infection on progression to cirrhosis in chronic hepatitis type B. J Infect Dis 1987; 155: 931–935.
- 108, , , , , , et al. Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B. The European Concerted Action on Viral Hepatitis (Eurohep). Gut 2000; 46: 420–426.
- 109, , , , , , et al. Interactions between human immunodeficiency virus-1, hepatitis delta virus and hepatitis B virus infections in 260 chronic carriers of hepatitis B virus. HEPATOLOGY 1992; 15: 578–583.
- 110, , , , , , et al. Care of patients with chronic hepatitis B and HIV co-infection: recommendations from an HIV-HBV International Panel. AIDS 2005; 19: 221–240.
- 111, , , , , , et al. Short statement of the first European Consensus Conference on the treatment of chronic hepatitis B and C in HIV co-infected patients. J Hepatol 2005; 42: 615–624.
- 112, , , , , , et al. HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS). Lancet 2002; 360: 1921–1926.
- 113, , . Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2006; 55: 1–23.
- 114. Molecular diagnosis of viral hepatitis. Gastroenterology 2002; 122: 1554–1568.
- 115, , , , , , et al. Real time TaqMan PCR detection and quantitation of HBV genotypes A-G with the use of an internal quantitation standard. J Clin Virol 2004; 30: 86–93.
- 116, , , . The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med 1996; 2: 1104–1108.
- 117, , . Quantitative serum HBV DNA levels during different stages of chronic hepatitis B infection. HEPATOLOGY 2002; 36: 1408–1415.
- 118, , , , , , et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002; 137: 1–10.
- 119, , , , . Acute exacerbation in chronic type B hepatitis: comparison between HBeAg and antibody-positive patients. HEPATOLOGY 1987; 7: 20–23.
- 120, . Management of hepatocellular carcinoma. HEPATOLOGY 2005; 42: 1208–1236.
- 121, . Antiviral drug resistance: clinical consequences and molecular aspects. Semin Liver Dis 2006; 26: 162–170.
- 122, , , , , , et al. YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection. HEPATOLOGY 1999; 29: 939–945.
- 123, , , , , , et al. Virologic response and resistance to adefovir in patients with chronic hepatitis B. J Hepatol 2006; 44: 283–290.
- 124, , , , , . Evolution of multi-drug resistant hepatits B viurs during sequential therapy: implications on rescue therapy. HEPATOLOGY 2006; 44: 703–712.
- 125, , , , , . Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis. [see comments]. Ann Intern Med 1993; 119: 312–323.
- 126, , . Which patients with chronic hepatitis B virus infection will respond to alpha-interferon therapy? A statistical analysis of predictive factors. [see comments]. HEPATOLOGY 1989; 10: 761–763.
- 127, , , , , , et al. A randomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. The Hepatitis Interventional Therapy Group. [see comments]. New Engl J Med 1990; 323: 295–301.
- 128, , , , , , et al. A controlled trial of interferon with or without prednisone priming for chronic hepatitis B. Gastroenterology 1992; 102: 2091–2097.
- 129, , , , , . Placebo-controlled trial of recombinant alpha 2-interferon in Chinese HBsAg-carrier children. Lancet 1987; 2: 877–880.
- 130, , , , , , et al. Effect of recombinant alpha 2 interferon with or without prednisone in Chinese HBsAg carrier children. Q J Med 1991; 78: 155–163.
- 131, , , . Long-term follow-up in a randomised controlled trial of recombinant alpha 2-interferon in Chinese patients with chronic hepatitis B infection. Lancet 1988; 2: 298–302.
- 132, . Interferon-alpha treatment of chronic hepatitis B in childhood: a consensus advice based on experience in European children. J Pediat Gastroenterol Nut 1999; 29: 163–170.
- 133, , , , , , et al. Lymphoblastoid interferon alfa with or without steroid pretreatment in children with chronic hepatitis B: a multicenter controlled trial. HEPATOLOGY 1996; 23: 700–707.
- 134, , , , , , et al. Interferon alfa therapy for chronic hepatitis B in children: a multinational randomized controlled trial. Gastroenterology 1998; 114: 988–995.
- 135, . Interferon-alpha therapy for chronic hepatitis B in children: a meta-analysis. Clin Infect Dis 1996; 23: 131–137.
- 136, , , , , , et al. A randomized, controlled trial of a 24-month course of interferon alfa 2b in patients with chronic hepatitis B who had hepatitis B virus DNA without hepatitis B e antigen in serum. HEPATOLOGY 1997; 26: 1621–1625.
- 137, , , , , , et al. A randomized controlled trial of lymphoblastoid interferon-alpha in patients with chronic hepatitis B lacking HBeAg. HEPATOLOGY 1992; 15: 584–589.
- 138, , , , , . Interferon alfa-2b treatment of HBeAg negative/serum HBV DNA positive chronic active hepatitis type B. J Hepatol 1990; 11(Suppl 1): S133–S136.
- 139, , , , , , et al. Anti-HBe-positive chronic hepatitis B with HBV-DNA in the serum response to a 6-month course of lymphoblastoid interferon. J Hepatol 1992; 14: 221–225.
- 140, , . The long-term outcome of interferon-alpha treated and untreated patients with HBeAg-negative chronic hepatitis B. J Hepatol 2001; 34: 306–313.
- 141, , , , , , et al. Long-term suppression of hepatitis B e antigen-negative chronic hepatitis B by 24-month interferon therapy. HEPATOLOGY 2003; 37: 756–763.
- 142, . Interferon alpha treatment and retreatment of hepatitis B e antigen-negative chronic hepatitis B. Gastroenterology 2001; 121: 101–109.
- 143, , , , , , et al. Low-dose, titratable interferon alfa in decompensated liver disease caused by chronic infection with hepatitis B virus. Gastroenterology 1995; 109: 908–916.
- 144, , , . Interferon alfa for patients with clinically apparent cirrhosis due to chronic hepatitis B. Gastroenterology 1993; 104: 1116–1121.
- 145, , , . Long-term follow-up of chronic hepatitis B patients treated with interferon alfa. Gastroenterology 1993; 105: 1833–1838.
- 146, , , , , . Long-term remission of chronic hepatitis B after alpha-interferon therapy. Annals of Internal Medicine 1991; 114: 629–634.
- 147. The long-term effect of treatment with interferon-alpha 2a in chronic hepatitis B. The Long-Term Follow-up Investigator Group. The European Study Group on Viral Hepatitis (EUROHEP). Executive Team on Anti-Viral Treatment. J Viral Hepat 1998; 5: 389–397.Direct Link:
- 148, , , , . Long-term follow-up of hepatitis B chronic carriers who responded to interferon therapy. J Hepatol 1992; 15: 102–106.
- 149, , , , , . Long-term follow-up of interferon alfa treatment in Chinese patients with chronic hepatitis B infection: The effect on hepatitis B e antigen seroconversion and the development of cirrhosis-related complications. HEPATOLOGY 2001; 34: 139–145.
- 150, , , , , , et al. Long-term follow-up of alpha-interferon treatment of patients with chronic hepatitis B. HEPATOLOGY 2004; 39: 804–810.
- 151, , , , , , et al. Peginterferon alpha-2a (40 kDa): an advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B. J Viral Hepat 2003; 10: 298–305.
- 152, , , , , , et al. A randomized, controlled trial of combination therapy for chronic hepatitis B: comparing pegylated interferon-alpha2b and lamivudine with lamivudine alone. Ann Intern Med 2005; 142: 240–250.
- 153, , , , , , et al. Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2004; 351: 1206–1217.
- 154, , , , , , et al. Lamivudine as initial treatment for chronic hepatitis B in the United States. New Engl J Med 1999; 341: 1256–1263.
- 155, , , , , , et al. A one-year trial of lamivudine for chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. [see comments]. New Engl J Med 1998; 339: 61–68.
- 156, , , , , , et al. Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial. [see comments]. Gut 2000; 46: 562–568.
- 157, , , , , , et al. Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. [see comments]. Gastroenterology 2000; 119: 172–180.
- 158, , , , , , et al. Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after 3 years of therapy. HEPATOLOGY 2001; 33: 1527–1532.
- 159, , , , , , et al. Four years of lamivudine treatment in Chinese patients with chronic hepatitis B. J Gastroenterol Hepatol 2004; 19: 1276–1282.
- 160, , , , , , et al. Long-term safety of lamivudine treatment in patients with chronic hepatitis B. Gastroenterology 2003; 125: 1714–1722.
- 161, , . Pretherapy alanine transaminase level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B. Asian Hepatitis Lamivudine Trial Group. HEPATOLOGY 1999; 30: 770–774.
- 162, , , , , , et al. Predictors of HBeAg loss after lamivudine treatment for chronic hepatitis B. HEPATOLOGY 2002; 36: 186–194.
- 163, , , , , , et al. Clinical trial of lamivudine in children with chronic hepatitis B. N Engl J Med 2002; 346: 1706–1713.
- 164, , , , , , et al. Long-term lamivudine therapy for children with HBeAg-positive chronic hepatitis B. HEPATOLOGY 2006; 43: 225–232.
- 165, , , , , , et al. Efficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis B. Lamivudine Precore Mutant Study Group. HEPATOLOGY 1999; 29: 889–896.
- 166, , , , , . Long-term follow-up of patients with anti-HBe/HBV DNA-positive chronic hepatitis B treated for 12 months with lamivudine. J Hepatol 2000; 32: 300–306.
- 167, , , , , , et al. Evolution of hepatitis B virus polymerase gene mutations in hepatitis B e antigen-negative patients receiving lamivudine therapy. [see comments]. HEPATOLOGY 2000; 32: 1145–1153.
- 168, , , , . Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B. HEPATOLOGY 2000; 32: 847–851.
- 169, , , , , , et al. Long-term therapy of chronic hepatitis B with lamivudine. HEPATOLOGY 2000; 32: 828–834.
- 170, , . Response of pre-core mutant chronic hepatitis B infection to lamivudine. J Med Virol 2000; 61: 398–402.
- 171, , , , . Course of virologic breakthroughs under long-term lamivudine in HBeAg-negative precore mutant HBV liver disease. HEPATOLOGY 2002; 36: 219–226.
- 172, , , , , , et al. Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine. HEPATOLOGY 2005; 42: 121–129.
- 173, , , , , , et al. Lamivudine and 24 weeks of lamivudine/interferon combination therapy for hepatitis B e antigen-positive chronic hepatitis B in interferon nonresponders. J Hepatol 2003; 38: 818–826.
- 174, , , , , , et al. A multicenter United States-Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B. HEPATOLOGY 2001; 33: 424–432.
- 175, , , , , , et al. Lamivudine treatment for decompensated cirrhosis resulting from chronic hepatitis B. HEPATOLOGY 2000; 31: 207–210.
- 176, . Lamivudine treatment in patients with severely decompensated cirrhosis due to replicating hepatitis B infection. [see comments]. J Hepatol 2000; 33: 301–307.
- 177, , , , , , et al. Determinants of early mortality in patients with decompensated chronic hepatitis B treated with antiviral therapy. Gastroenterology 2002; 123: 719–727.
- 178, , , , , , et al. Durability of serologic response after lamivudine treatment of chronic hepatitis B. HEPATOLOGY 2003; 37: 748–755.
- 179, , , , . Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea. HEPATOLOGY 2000; 32: 803–806.
- 180, , , , , . Effect of virological response on post-treatment durability of lamivudine-induced HBeAg seroconversion. J Viral Hepat 2002; 9: 208–212.
- 181, , , , , , et al. Long-term additional lamivudine therapy enhances durability of lamivudine-induced HBeAg loss: a prospective study. J Hepatol 2003; 39: 614–619.
- 182, , , , , , et al. Quantitative polymerase chain reaction assay for serum hepatitis B virus DNA as a predictive factor for post-treatment relapse after lamivudine induced hepatitis B e antigen loss or seroconversion. Gut 2003; 52: 1779–1783.
- 183, , , , . Determinants for sustained HBeAg response to lamivudine therapy. HEPATOLOGY 2003; 38: 1267–1273.
- 184, , , , , , et al. Durability of HBeAg seroconversion following antiviral therapy for chronic hepatitis B: relation to type of therapy and pretreatment serum hepatitis B virus DNA and alanine aminotransferase. Gut 2003; 52: 420–424.
- 185, , , . Sustained response after a 2-year course of lamivudine treatment of hepatitis B e antigen-negative chronic hepatitis B. J Viral Hepat 2004; 11: 432–438.
- 186, , , , , , , et al. Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Lamivudine Clinical Investigation Group. HEPATOLOGY 1998; 27: 1670–1677.
- 187, , , , , , . Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region. HEPATOLOGY 2001; 33: 751–757.
- 188, , , , , . Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy. HEPATOLOGY 2001; 34: 785–791.
- 189, , . Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective. HEPATOLOGY 1998; 27: 628–633.
- 190, , , , . Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy. [see comments]. HEPATOLOGY 1999; 30: 567–572.
- 191, , , , , , et al. Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation. [see comments]. Lancet 1997; 349: 20–22.
- 192, , , , , . Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo. HEPATOLOGY 1996; 24: 714–717.
- 193, , . No benefit to continue lamivudine therapy after emergence of YMDD mutations. Antivir Ther 2004; 9: 257–262.
- 194, , , , . Clinical course after stopping lamivudine in chronic hepatitis B patients with lamivudine-resistant mutants. Aliment Pharmacol Ther 2004; 19: 323–329.
- 195, , , , , , et al. Histological outcome during long-term lamivudine therapy. Gastroenterology 2003; 124: 105–117.
- 196, , , , , , et al. Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine. HEPATOLOGY 2004; 40: 883–891.
- 197, , , , . Acute exacerbation of chronic hepatitis B virus infection after withdrawal of lamivudine therapy. HEPATOLOGY 2000; 32: 635–639.
- 198, , , , , , et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med 2003; 348: 808–816.
- 199, , , , , , et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B. N Engl J Med 2003; 348: 800–807.
- 200, , , , , , et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B. N Engl J Med 2005; 352: 2673–2681.
- 201, , , , , , et al. Long-term adefovir dipivoxil treatment induces regression of liver fibrosis in patients with HBeAg-negative chronic hepatitis B: Results after 5 years of therapy [Abstract]. HEPATOLOGY 2005; 42(Suppl): 754A.
- 202, , , , , , et al. Adefovir dipivoxil therapy for lamivudine-resistant hepatitis B in pre- and post-liver transplantation patients. HEPATOLOGY 2003; 38: 1419–1427.
- 203, , , , , . Adefovir Dipivoxil (ADV) provides significant clinical benefit, reduces meld score and prevents transplantation in chronic hepatitis B patients wait-listed for liver transplantation (OLT) with Lamivudine-Resistance (LAM-R) [Abstract]. J Hepatol 2005; 42(Suppl 2): 5.
- 204, , , , , , et al. Combination of Adefovir Dipivoxil (ADV) and Lamivudine (LAM) prevented emergence of ADV resistance Mutations in chronic Hepatitis B (CHB) patients with LAM-Resistant HBV [Abstract]. Gastroenterology 2005; 128: M945.
- 205, , , , , , et al. Safety and efficacy of adefovir dipivoxil in patients infected with lamivudine-resistant hepatitis B and HIV-1. J Hepatol 2006; 44: 62–67.
- 206, , , , , , et al. Entecavir is superior to Lamivudine for the treatment of HBEAg(+) chronic hepatitis B: Results of Phase III study ETV - 022 in Nucleoside-Naive patients [Abstract]. HEPATOLOGY 2004; 40(Suppl): 193A.
- 207, , , , , , et al. Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B. HEPATOLOGY 2003; 38: 96–103.
- 208, , , , , , et al. Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase. Gastroenterology 2003; 125: 292–297.
- 209, , , , , , et al. Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient. J Hepatol 2003; 39: 1085–1089.
- 210, , , , , , et al. Incidence and predictors of emergence of Adefovir resistant HBV during four years of Adefovir Dipivoxil (ADV) Therapy for patients with chronic hepatitis B (CHB) [Abstract]. J Hepatol 2005; 42: 17.
- 211, , , , , , et al. Increased risk of adefovir resistance in patients with lamivudine-resistant chronic hepatitis B after 48 weeks of adefovir dipivoxil monotherapy. HEPATOLOGY 2006; 43: 1385–1391.
- 212, , , , , , et al. Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation. J Hepatol 2005; 43: 937–943.
- 213, , , , , , et al. Different profiles of response to Adefovir Dipivoxil and factors that may influence response in patients with chronic Hepatitis B. HEPATOLOGY 2004; 40: 654A.
- 214, , , , , , et al. Hepatitis B virus genotypes and virologic response in 694 patients in phase III studies of adefovir dipivoxil1. Gastroenterology 2003; 125: 107–116.
- 215, , , , , , et al. The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance. J Clin Invest 2001; 107: 449–455.
- 216, , , , , , et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med 2006; 354: 1001–1010.
- 217, , , , , , et al. Entecavir results in substantial virologic and biochemical improvement and HBeAg seroconversion through 96 weeks of treatment in HBeAg(+) Chronic hepatitis B patients (Study ETV-022) [Abstract]. HEPATOLOGY 2005; 42 (Suppl) : 267A.
- 218, , , , , , et al. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2006; 354: 1011–1020.
- 219, , , , , , et al. A dose-ranging study of the efficacy and tolerability of entecavir in Lamivudine-refractory chronic hepatitis B patients. Gastroenterology 2005; 129: 1198–1209.
- 220, , , , , , et al. Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B. Gastroenterology 2006; 130: 2039–2049.
- 221, , , , , , et al. Resistance after two years of entecavir treatment in nucleoside-naive patients is rare. HEPATOLOGY 2006; 45: 1656–1665.
- 222, , , , , , et al. Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine. Antimicrob Agents Chemother 2004; 48: 3498–3507.
- 223, , , , , , et al. Entecavir is effective irrespective of Baseline Alt nad HBV DNA Strata for Histological and Virological Endpoints [Abstract]. Gastroenterology 2005; 128: 742.
- 224Entecavir Review Team. Briefing document for NDA 21-797, entecavir 0.5 and 1 mg tablets and NDA 21-798, entcavir oral solution 0.05 mg/mL. www.fda.gov/ohrms/dockets/ac/05/briefing/2005-4094B1_02_FDA-Background-Memo.pdf.
- 225, , , , , , et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. Gastroenterology 2005; 129: 528–536.
- 226, , , , , , et al. Phase Iib extended-treatment trial of telbivudine (LdT) vs lamivudine vs combination treatment in hepatitis B patients: two year results [Abstract]. Gastroenterology 2005; 128: A692.
- 227, , , , , , et al. Telbivudine (LDT) Vs. Lamivudine for Chronic Hepatitis B: First — year results from the international phase III globe trial [Abstract]. HEPATOLOGY 2005; 42(Suppl): 748A.
- 228, , , , , , et al. Two-Year results from the Globe Trial in patients with hepatitis B: Greater clinical and antiviral efficacy for telbivudine (LDT) vs. lamivudine [Abstract]. HEPATOLOGY 2006; 44(Suppl): 222A.
- 229, , , , , , et al. Telbivudine Globe Trial: Maximal early HBV suppression is predictive of optimal two-year efficacy in nucleoside-treated hepatitis B patients. HEPATOLOGY 2006; 44(Suppl): 230A–231A.
- 230, , , , , , et al. A double-blind placebo-controlled study of emtricitabine in chronic hepatitis B. Arch Intern Med 2006; 166: 49–56.
- 231, , , , , , et al. Tenofovir disoproxil fumarate therapy for chronic hepatitis B in human immunodeficiency virus/hepatitis B virus-coinfected individuals for whom interferon-alpha and lamivudine therapy have failed. J Infect Dis 2002; 186: 1844–1847.
- 232, , , , , , et al. Randomized controlled study of tenofovir and adefovir in chronic hepatitis B virus and HIV infection: ACTG A5127. HEPATOLOGY 2006; 44: 1110–1116.
- 233, , , , , , et al. Anti-hepatitis B virus efficacy of tenofovir disoproxil fumarate in HIV-infected patients. HEPATOLOGY 2006; 43: 548–555.
- 234, , , , , , et al. Efficacy of tenofovir disoproxil fumarate in antiretroviral therapy-naive and -experienced patients coinfected with HIV-1 and hepatitis B virus. J Infect Dis 2004; 189: 1185–1192.
- 235, , . Tenofovir disoproxil fumarate for the treatment of lamivudine-resistant hepatitis B. Clin Gastroenterol Hepatol 2004; 2: 266–272.
- 236, , , , , , et al. Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection. HEPATOLOGY 2004; 40: 1421–1425.
- 237, . Reactivation of viral replication after replacement of tenofovir by adefovir. HEPATOLOGY 2005; 42: 239–240.
- 238, , , , , , et al. Fanconi syndrome and renal failure induced by tenofovir: a first case report. Am J Kidney Dis 2002; 40: 1331–1333.
- 239, , , , , , et al. A 24-week clevudine monotherapy produced profound on-treatment viral suppression as as sustained viral suppression and normalization of aminotransferase levels for 24 weeks off-treatment in HBEAg(+) chronic hepatitis B patients [Abstract]. HEPATOLOGY 2005; 42(Suppl): 270A.
- 240, , , , , , et al. Clevudine is highly efficacious in HBEAg(−) chronic Hepatits B patients with a sustained antiviral effect after cessation of therapy [Abstract]. HEPATOLOGY 2005; 42(Suppl): 268A.
- 241, , , , , , et al. A randomized controlled trial of thymosin-alpha1 versus interferon alfa treatment in patients with hepatitis B e antigen antibody–and hepatitis B virus DNA–positive chronic hepatitis B. HEPATOLOGY 1996; 24: 774–777.
- 242, , , , . Efficacy of thymosin alpha1 in patients with chronic hepatitis B: a randomized, controlled trial. HEPATOLOGY 1998; 27: 1383–1387.
- 243, , , , , , et al. Thymosin alpha1 treatment of chronic hepatitis B: results of a phase III multicentre, randomized, double-blind and placebo-controlled study. J Viral Hepat 1999; 6: 397–403.Direct Link:
- 244, , , , , , et al. A randomized, controlled study of thymosin-alpha1 therapy in patients with anti-HBe, HBV-DNA-positive chronic hepatitis B. Dig Dis Sci 2000; 45: 690–696.
- 245, , , . The efficacy of thymosin in the treatment of chronic hepatitis B virus infection: a meta-analysis. Aliment Pharmacol Ther 2001; 15: 1899–1905.
- 246, , , , , , et al. A randomized double-blind phase II study of lamivudine compared to lamivudine plus adefovir dipivoxil for treatment naïve patients with chronic hepatitis B: week 52 analysis. J Hepatol 2003: 25.
- 247A Phase II Study of Lamivudine Compared to Lamivudine Plus Adefovir Dipivoxil for Subjects With Chronic Hepatitis B. http://ctr.gsk.co.uk/Summary/lamivudine/II_NUC20912.
- 248, , , , , , , et al. Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B. Gastroenterology 2004; 126: 91–101.
- 249, , , , , , et al. Combination therapy with interferon-alpha and ribavirin in patients with dual hepatitis B and hepatitis C virus infection. J Gastroenterol Hepatol 2005; 20: 727–732.
- 250, , , , , . Ribavirin and interferon is effective for hepatitis C virus clearance in hepatis B and C dually infected patients. HEPATOLOGY 2003; 37: 568–576.
- 251, , , , , , et al. High doses of alpha-interferon are required in chronic hepatitis due to coinfection with hepatitis B virus and hepatitis C virus: long term results of a prospective randomized trial. Am J Gastroenterol 2001; 96: 2973–2977.
- 252, , , , , , et al. Treatment of chronic hepatitis D with interferon alfa-2a. N Engl J Med 1994; 330: 88–94.
- 253, , , , , , et al. Long-term benefit of interferon alpha therapy of chronic hepatitis D: regression of advanced hepatic fibrosis. Gastroenterology 2004; 126: 1740–1749.
- 254, , , , , , et al. Pegylated interferon alpha-2b as monotherapy or in combination with ribavirin in chronic hepatitis delta. HEPATOLOGY 2006; 44: 713–720.
- 255, , , , , , et al. Efficacy of peginterferon alpha-2b in chronic hepatitis delta: relevance of quantitative RT-PCR for follow-up. HEPATOLOGY 2006; 44: 728–735.
- 256, , , , , , et al. Lamivudine for chronic delta hepatitis. HEPATOLOGY 1999; 30: 546–549.
- 257, , , , , , et al. Influence of HIV infection on the response to interferon therapy and the long-term outcome of chronic hepatitis B. Gastroenterology 2002; 123: 1812–1822.
- 258, , , . Evaluation of chronic hepatitis B virus (HBV) infection in coinfected patients receiving lamivudine as a componet of anti-human immunodeficiency virus regimens. Clin Infect Dis 2001; 32: 963–969.
- 259, , , , , , et al. Long-term incidence of hepatitis B virus resistance to lamivudine in human immunodeficiency virus-infected patitents. HEPATOLOGY 2000; 31: 1030–1031.
- 260, , , . Ninety-six-week efficacy of combination therapy with lamivudine and tenofovir in patients coinfected with HIV-1 and wild-type hepatitis B virus. Clin Infect Dis 2004; 39: 1062–1064.
- 261, , , , , , et al. Risk of selecting K65R in antiretroviral-naive HIV-infected individuals with chronic hepatitis B treated with adefovir. AIDS 2005; 19: 2036–2038.
- 262, , , , , . Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Report of a prospective study. Gastroenterology 1991; 100: 182–188.
- 263, , , , , , et al. Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors. Journal of Medical Virology 2000; 62: 299–307.
- 264, . Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy. HEPATOLOGY 2006; 43: 209–220.
- 265, , , , , , et al. Steroid-free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV-carriers with lymphoma. HEPATOLOGY 2003; 37: 1320–1328.
- 266, , , , . Hepatitis B reactivation in a chronic hepatitis B surface antigen carrier with rheumatoid arthritis treated with infliximab and low dose methotrexate. Ann Rheum Dis 2003; 62: 686–687.
- 267, , , , , . Chronic hepatitis B reactivation following infliximab therapy in Crohn's disease patients: need for primary prophylaxis. Gut 2004; 53: 1363–1365.
- 268, , , , , , et al. Preemptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation. HEPATOLOGY 2002; 36: 702–709.
- 269, , , , , , et al. Early is superior to deferred preemptive lamivudine therapy for hepatitis B patients undergoing chemotherapy. Gastroenterology 2003; 125: 1742–1749.
- 270, , , . Primary prophylaxis with lamivudine of hepatitis B virus reactivation in chronic HbsAg carriers with lymphoid malignancies treated with chemotherapy. Br J Haematol 2001; 115: 58–62.
- 271, , , , , . Preemptive lamivudine therapy based on HBV DNA level in HBsAg-positive kidney allograft recipients. HEPATOLOGY 2002; 36: 1246–1252.
- 272, , , , , , et al. Hepatitis B reactivation after withdrawal of pre-emptive lamivudine in patients with haematological malignancy on completion of cytotoxic chemotherapy. Gut 2005; 54: 1597–1603.
- 273, , . The use of lamivudine for patients with acute hepatitis B (a series of cases). J Viral Hepat 2004; 11: 427–431.
- 274, , , , , , et al. Safety and efficacy of lamivudine in patients with severe acute or fulminant hepatits B: A multicenter experience. J Viral Hepatol 2006; 4: 256–263.
- 275, , , , . Recombinant interferon-alpha therapy for acute hepatitis B: a randomized double-blind, placebo-controlled trial. J Viral Hepat 1997; 4: 387–394.

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