These authors contributed equally to this work.
Combined GM-CSF and IL-12 gene therapy synergistically suppresses the growth of orthotopic liver tumors†
Article first published online: 26 FEB 2007
Copyright © 2007 American Association for the Study of Liver Diseases
Volume 45, Issue 3, pages 746–754, March 2007
How to Cite
Chang, C.-J., Chen, Y.-H., Huang, K.-W., Cheng, H.-W., Chan, S.-F., Tai, K.-F. and Hwang, L.-H. (2007), Combined GM-CSF and IL-12 gene therapy synergistically suppresses the growth of orthotopic liver tumors. Hepatology, 45: 746–754. doi: 10.1002/hep.21560
Potential conflict of interest: Nothing to report.
- Issue published online: 26 FEB 2007
- Article first published online: 26 FEB 2007
- Manuscript Accepted: 9 NOV 2006
- Manuscript Received: 4 AUG 2006
- National Science Council of the Republic of China. Grant Number: NSC 94-3112-B-002-016
- Liver Disease and Treatment Research Foundation
Supplementary material for this article can be found on the H EPATOLOGY Web site ( http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html ).
|jws-hep.21560.pdf||154K||Supplementary Fig. 1: Representative photographs of the livers in the rats with multifocal liver tumors treated with adenoviruses. Animals bearing multifocal liver tumors were treated as described in the legend to Fig. 1C. Liver pictures were taken from animals treated with Ad/GFP (A), Ad/GM-CSF (B), Ad/IL-12 (C), or Ad/combined (D). Arrows indicate the presence of tumors. Significantly fewer pr smaller tumor nodules were observed in the livers of the animals receiving Ad/IL-12 or Ad/combined therapy.|
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