• 1
    Trey C, Davidson CS. The management of fulminant hepatic failure. Prog Liver Dis 1970; 3: 282298.
  • 2
    Crippin JS, Gross JB Jr, Lindor KD. Increased intracranial pressure and hepatic encephalopathy in chronic liver disease. Am J Gastroenterol 1992; 87: 879882.
  • 3
    Jalan R, Dabos K, Redhead DN, Lee A, Hayes PC. Elevation of intracranial pressure following transjugular intrahepatic portosystemic stent-shunt for variceal haemorrhage. J Hepatol 1997; 27: 928933.
  • 4
    Donovan JP, Schafer DF, Shaw BW Jr, Sorrell MF. Cerebral oedema and increased intracranial pressure in chronic liver disease. Lancet 1998; 351: 719721.
  • 5
    Ong JP, Aggarwal A, Krieger D, Easley KA, Karafa MT, Van Lente F, et al. Correlation between ammonia levels and the severity of hepatic encephalopathy. Am J Med 2003; 114: 188193.
  • 6
    Clemmesen JO, Larsen FS, Kondrup J, Hansen BA, Ott P. Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. HEPATOLOGY 1999; 29: 648653.
  • 7
    Haussinger D, Laubenberger J, vom Dahl S, Ernst T, Bayer S, Langer M, et al. Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology 1994; 107: 14751480.
  • 8
    Cordoba J, Gottstein J, Blei AT. Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema. HEPATOLOGY 1996; 24: 919923.
  • 9
    Tofteng F, Hauerberg J, Hansen BA, Pedersen CB, Jorgensen L, Larsen FS. Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure. J Cereb Blood Flow Metab 2006; 26: 2127.
  • 10
    Rolando N, Wade J, Davalos M, Wendon J, Philpott-Howard J, Williams R. The systemic inflammatory response syndrome in acute liver failure. HEPATOLOGY 2000; 32: 734739.
  • 11
    Vaquero J, Polson J, Chung C, Helenowski I, Schiodt FV, Reisch J, et al. Infection and the progression of hepatic encephalopathy in acute liver failure. Gastroenterology 2003; 125: 755764.
  • 12
    Jalan R, Olde Damink SW, Hayes PC, Deutz NE, Lee A. Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow. J Hepatol 2004; 41: 613620.
  • 13
    Weissenborn K, Bokemeyer M, Ahl B, Fischer-Wasels D, Giewekemeyer K, van den Hoff J, et al. Functional imaging of the brain in patients with liver cirrhosis. Metab Brain Dis 2004; 19: 269280.
  • 14
    Shawcross DL, Davies NA, Williams R, Jalan R. Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol 2004; 40: 247254.
  • 15
    Harry D, Anand R, Holt S, Davies S, Marley R, Fernando B, et al. Increased sensitivity to endotoxemia in the bile duct-ligated cirrhotic rat. HEPATOLOGY 1999; 30: 11981205.
  • 16
    Olde Damink SW, Jalan R, Deutz NE, Redhead DN, Dejong CH, Hynd P, et al. The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis. HEPATOLOGY 2003; 37: 12771285.
  • 17
    Balata S, Damink SW, Ferguson K, Marshall I, Hayes PC, Deutz NE, et al. Induced hyperammonemia alters neuropsychology, brain MR spectroscopy and magnetization transfer in cirrhosis. HEPATOLOGY 2003; 37: 931939.
  • 18
    Matkowskyj KA, Marrero JA, Carroll RE, Danilkovich AV, Green RM, Benya RV. Azoxymethane-induced fulminant hepatic failure in C57BL/6J mice: characterization of a new animal model. Am J Physiol 1999; 277: G455G462.
  • 19
    Marmarou A, Tanaka K, Shulman K. An improved gravimetric measure of cerebral edema. J Neurosurg 1982; 56: 246253.
  • 20
    Gips CH, Wibbens-Alberts M. Ammonia determination in blood using the TCA direct method. Clin Chim Acta 1968; 22: 183186.
  • 21
    Zwingmann C, Chatauret N, Leibfritz D, Butterworth RF. Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study. HEPATOLOGY 2003; 37: 420428.
  • 22
    Kriat M, Confort-Gouny S, Vion-Dury J, Sciaky M, Viout P, Cozzone PJ. Quantitation of metabolites in human blood serum by proton magnetic resonance spectroscopy: a comparative study of the use of formate and TSP as concentration standards. NMR Biomed 1992; 5: 179184.
  • 23
    Giovannoni G, Land JM, Keir G, Thompson EJ, Heales SJ. Adaptation of the nitrate reductase and Griess reaction methods for the measurement of serum nitrate plus nitrite levels. Ann Clin Biochem 1997; 34: 193198.
  • 24
    Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001; 5: 6271.
  • 25
    Sen S, Davies NA, Mookerjee RP, Cheshire LM, Hodges SJ, Williams R, et al. Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study. Liver Transpl 2004; 10: 11091119.
  • 26
    Ottesen LH, Harry D, Frost M, Davies S, Khan K, Halliwell B, et al. Increased formation of S-nitrothiols and nitrotyrosine in cirrhotic rats during endotoxemia. Free Radic Biol Med 2001; 31: 790798.
  • 27
    Frost MT, Halliwell B, Moore KP. Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifacts. Biochem J 2000; 345 Pt 3: 453458.
  • 28
    Moore KP, Mani AR. Measurement of protein nitration and S-nitrosothiol formation in biology and medicine. Methods Enzymol 2002; 359: 256268.
  • 29
    Davies NA, Brealey DA, Stidwill R, Singer M, Svistunenko DA, Cooper CE. Nitrosyl heme production compared in endotoxemic and hemorrhagic shock. Free Radic Biol Med 2005; 38: 4149.
  • 30
    Traber PG, Dal Canto M, Ganger DR, Blei AT. Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: ultrastructure and integrity of the blood-brain barrier. HEPATOLOGY 1987; 7: 12721277.
  • 31
    Traber PG, Ganger DR, Blei AT. Brain edema in rabbits with galactosamine-induced fulminant hepatitis. Regional differences and effects on intracranial pressure. Gastroenterology 1986; 91: 13471356.
  • 32
    Kato M, Sugihara J, Nakamura T, Muto Y. Electron microscopic study of the blood-brain barrier in rats with brain edema and encephalopathy due to acute hepatic failure. Gastroenterol Jpn 1989; 24: 135142.
  • 33
    Schliess F, Gorg B, Fischer R, Desjardins P, Bidmon HJ, Herrmann A, et al. Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes. FASEB J 2002; 16: 739741.
  • 34
    Lee JC, Cho GS, Kim HJ, Lim JH, Oh YK, Nam W, et al. Accelerated cerebral ischemic injury by activated macrophages/microglia after lipopolysaccharide microinjection into rat corpus callosum. Glia 2005; 50: 168181.
  • 35
    Jover R, Rodrigo R, Felipo V, Insausti R, Saez-Valero J, Garcia-Ayllon MS, et al. Brain edema and inflammatory activation in bile duct ligated rats with diet-induced hyperammonemia: a model of hepatic encephalopathy in cirrhosis. HEPATOLOGY 2006; 43: 12571266.
  • 36
    Gorg B, Bidmon HJ, Keitel V, Foster N, Goerlich R, Schliess F, et al. Inflammatory cytokines induce protein tyrosine nitration in rat astrocytes. Arch Biochem Biophys 2006; 449: 104114.
  • 37
    Guevara M, Bru C, Gines P, Fernandez-Esparrach G, Sort P, Bataller R, et al. Increased cerebrovascular resistance in cirrhotic patients with ascites. HEPATOLOGY 1998; 28: 3944.