Josep M. Llovet is Professor of Research at Institut Català de Recerca Avancada (ICREA, IDIBAPS, Hospital Clínic).
Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma†
Version of Record online: 28 MAR 2007
Copyright © 2007 American Association for the Study of Liver Diseases
Volume 45, Issue 4, pages 938–947, April 2007
How to Cite
Wurmbach, E., Chen, Y.-b., Khitrov, G., Zhang, W., Roayaie, S., Schwartz, M., Fiel, I., Thung, S., Mazzaferro, V., Bruix, J., Bottinger, E., Friedman, S., Waxman, S. and Llovet, J. M. (2007), Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology, 45: 938–947. doi: 10.1002/hep.21622
Potential conflict of interest: Nothing to report.
- Issue online: 28 MAR 2007
- Version of Record online: 28 MAR 2007
- Manuscript Accepted: 30 NOV 2006
- Manuscript Received: 9 OCT 2006
- Samuel Waxman Cancer Research Foundation
- National Institutes of Health. Grant Number: DK37340
- Bendheim Family Trust
- Instituto de Salud Carlos III. Grant Number: FIS 05/1285
- Italian Association for Cancer Research
Supplementary material for this article can be found on the H EPATOLOGY website ( http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html ).
|jws-hep.21622.fig1.pdf||89K||Supplementary Fig. 1.Heat maps from genes detected by SAM. A) control ? cirrhosis (112 genes), B) cirrhosis ? dysplastic nodules (29 genes), C) dysplastic nodules ? HCC (693 genes), D) dysplastic nodules ? ve/e HCC (104 genes), E) ve/e HCC ? a/aa HCC (9 genes); red: up-regulated, green: down-regulated, black: no change|
|jws-hep.21622.fig2.pdf||67K||Supplementary Fig. 2.PAM: cross-validated probabilities: A) control ? cirrhosis (9 genes), B) cirrhosis ? dysplastic nodules (59 genes), C) dysplastic nodules ? HCC (61 genes), D) dysplastic nodules ? ve/e HCC (350 genes), E) ve/e HCC ? a/aa HCC (120 genes). A-E) X-axis=sample as indicated at top of the figure, y-axis=calculated probability, which for each sample must sum to 1.|
|jws-hep.21622.fig3.pdf||1198K||Supplementary Fig. 3.Heat maps of pathways in HCV induced HCC. In each panel the samples (columns) are sorted successively from control to very advanced HCC (control, pre-cancerous and HCC stages are separated by dashed lines). The expression pattern (red=up-regulation, green=down-regulation, black=no change) of the genes is shown in rows.|
|jws-hep.21622.tbl1.pdf||10K||Supplementary Table 1:Pathological characteristics and quality control of the tissue samples.|
|jws-hep.21622.tbl2.pdf||8K||Supplementary Table 2:Accession numbers and primer sequences of genes used for qPCR|
|jws-hep.21622.tbl3.pdf||24K||Supplementary Table 3:Genes that provide a molecular classification of each of the stages of HCV induced hepatocarcinogenesis|
|jws-hep.21622.tbl4-.pdf||11K||Supplementary Table 4:Numbers of obviously dysregulated genes associated with the pathways analyzed in HCV induced HCC|
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