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Coffee drinking and hepatocellular carcinoma risk: A meta-analysis†
Article first published online: 19 JUN 2007
DOI: 10.1002/hep.21708
Copyright © 2007 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Bravi, F., Bosetti, C., Tavani, A., Bagnardi, V., Gallus, S., Negri, E., Franceschi, S. and La Vecchia, C. (2007), Coffee drinking and hepatocellular carcinoma risk: A meta-analysis. Hepatology, 46: 430–435. doi: 10.1002/hep.21708
- †
Potential conflict of interest: Nothing to report.
Publication History
- Issue published online: 27 JUL 2007
- Article first published online: 19 JUN 2007
- Manuscript Accepted: 5 MAR 2007
- Manuscript Received: 30 JAN 2007
Funded by
- Italian Association for Cancer Research
- Italian League Against Cancer
- Italian Ministry of Research (PRIN 2005)
- Francesca Bravi is a Fellow of the Rosario Samanin Fund
References
- 1. Coffee, liver enzymes, cirrhosis and liver cancer. J Hepatol 2005; 42: 444–446.
- 2, , , , , , et al. Coffee consumption and serum aminotransferases in middle-aged Japanese men. J Clin Epidemiol 2001; 54: 823–829.
- 3, , , , . Coffee consumption and decreased serum gamma-glutamyltransferase: a study of middle-aged Japanese men. Eur J Epidemiol 2000; 16: 419–423.
- 4, . Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2005; 128: 24–32.
- 5, , , . Unexpected effects of coffee consumption on liver enzymes. Eur J Epidemiol 1993; 9: 293–297.
- 6, , , , , , et al. Coffee drinking and serum gamma-glutamyltransferase: an extended study of Self-Defense Officials of Japan. Ann Epidemiol 1999; 9: 325–331.
- 7, , , , . Coffee and serum gamma-glutamyltransferase: a study of self-defense officials in Japan. Am J Epidemiol 1994; 139: 723–727.
- 8, . Determinants of gamma-glutamyltransferase: positive interaction with alcohol and body mass index, negative association with coffee. Am J Epidemiol 1997; 146: 1019–1024.
- 9, . Re: “Alcohol, smoking, coffee, and cirrhosis” and “Coffee and serum gamma-glutamyltransferase: a study of self-defense officials in Japan”. Am J Epidemiol 1995; 141: 480–482.
- 10, , , , , , et al. Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers. Int J Epidemiol 1998; 27: 438–443.
- 11, , , , , , et al. Alcoholism and liver cirrhosis in the etiology of primary liver cancer. Int J Cancer 1992; 51: 898–902.Direct Link:
- 12, , , , , , et al. Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma. Int J Cancer 2000; 85: 498–502.Direct Link:
- 13, , , . Liver cirrhosis and the risk of primary liver cancer. Eur J Cancer Prev 1998; 7: 315–320.
- 14, , , , , , et al. The effect of drinking coffee and smoking cigarettes on the risk of cirrhosis associated with alcohol consumption. A case-control study. Provincial Group for the Study of Chronic Liver Disease. Eur J Epidemiol 1994; 10: 657–664.
- 15, , , , . Coffee, caffeine, and the risk of liver cirrhosis. Ann Epidemiol 2001; 11: 458–465.
- 16, , , . Does coffee protect against liver cirrhosis? Ann Epidemiol 2002; 12: 202–205.
- 17, . Alcohol, smoking, coffee, and cirrhosis. Am J Epidemiol 1992; 136: 1248–1257.
- 18
- 19, , , , , , et al. Coffee consumption and digestive tract cancers. Cancer Res 1989; 49: 1049–1051.
- 20, , , , , , et al. Does coffee protect against hepatocellular carcinoma? Br J Cancer 2002; 87: 956–959.
- 21, , , , , , et al. Coffee consumption reduces the risk of hepatocellular carcinoma independently of its aetiology: a case-control study. J Hepatol 2005; 42: 528–534.
- 22, , , , , , et al. Coffee and tea consumption and risk of hepatocellular carcinoma in Italy. Int J Cancer 2007; 120: 1555–1559.Direct Link:
- 23, , , , , , et al. Coffee consumption and reduced risk of hepatocellular carcinoma among patients with chronic type C liver disease: a case-control study. Hepatol Res 2006; 36: 201–208.
- 24, , , , , , et al. Inverse association between coffee drinking and the risk of hepatocellular carcinoma: a case-control study in Japan. Cancer Sci 2007; 98: 214–218.Direct Link:
- 25, , , , , , et al. Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China. Jpn J Cancer Res 2002; 93: 1287–1292.
- 26, , , . Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan. J Natl Cancer Inst 2005; 97: 293–300.
- 27, , , , , , et al. Coffee consumption and the risk of primary liver cancer: pooled analysis of two prospective studies in Japan. Int J Cancer 2005; 116: 150–154.Direct Link:
- 28, , , , , , et al. Coffee and risk of death from hepatocellular carcinoma in a large cohort study in Japan. Br J Cancer 2005; 93: 607–610.
- 29, . Publication bias in meta-analysis: its causes and consequences. J Clin Epidemiol 2000; 53: 207–216.
- 30, , , . Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629–634.
- 31. Quantitative methods in the review of epidemiologic literature. Epidemiol Rev 1987; 9: 1–30.
- 32, . Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177–188.
- 33, . Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol 1992; 135: 1301–1309.
- 34, , , , . The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis 1998; 19: 1369–1375.
- 35, , , , , , et al. Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2). Food Chem Toxicol 2005; 43: 433–441.
- 36, . Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk. Methods Enzymol 2005; 401: 307–341.
- 37. Is coffee or tea good for your liver? Nat Clin Pract Gastroenterol Hepatol 2006; 3: 482–483.
- 38, , , , . Reliability of information on cigarette smoking and beverage consumption provided by hospital controls. Epidemiology 1996; 7: 312–315.
- 39, , , , , , et al. Reproducibility and validity of coffee and tea consumption in Italy. Eur J Clin Nutr 2004; 58: 674–680.
- 40, , , . Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74–108.Direct Link:

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