SEARCH

SEARCH BY CITATION

In the March 2007 article “Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity” by Rollier et al. (Volume 45, pages 602-613), several references to citations were numbered incorrectly.

The correct numbered references are listed as follows:

Page 602, Abstract, lines 12-13; the correct sentence reads as:

However, expression of IDO, CTLA-4 and PD-1 levels in liver correlated with clearance or chronicity.

Page 603, left column, penultimate line; the correct sentence reads as:

The NS3 encoding plasmid was described previously.24

Page 603, right column, lines 13-15; the correct sentence reads as:

Recombinant viruses were amplified and purified by ultracentrifugation through sucrose.28

Page 604, left column, lines 8-13; the correct sentence reads as:

ELISA was performed as described previously (Komurian-Pradel et al., in press). The capacity of the chimpanzee sera to neutralize HCV was analyzed using HCV pseudo-particles in infection assays on HuH-7 target cells as described.30 HCV pseudoparticles were generated as described using expression vectors encoding the viral components including E1E2 glycoproteins of strain CG1b.31

Page 604, left column, lines 20-25; the correct sentence reads as:

Quantification of specific cytokine secreting cells was performed using IFN-γ, interleukin 2 (IL-2) and IL-4 enzyme-linked immunospot (ELISPOT) assays according to the manufacturer's instructions (U-Cytech, Utrecht, Netherlands) and as described,17

Page 604, left column, last three lines from bottom; the correct sentence reads as:

Sera were tested for a quantitative HCV RNA by real-time PCR of the 5′ HCV noncoding region.34,35

Page 604, right column, lines 22-24; the correct sentence reads as:

Expression of PD-1, Foxp3, CTLA-4, IDO and Cox2 mRNA in liver was quantified as described.37

Page 611, right column, lines 2-5: the correct sentence reads as:

For this study, we used a heterologous HCV 1b J4 isolate that has previously established chronic infection in all 7 naïve chimpanzees in which it had been used.17, 39-41

Page 611, right column, lines 10-12: the correct sentence reads as:

Similar results were observed recently with a T cell–based vaccine against an HCV 1a challenge.7

Page 611, right column, lines 17-19: the correct sentence reads as:

Early peak viral titers are a characteristic of this inoculum, occurring between 1 to 2.5 weeks after exposure.17,39,40

Page 612, left column, lines 13-16: the correct sentence reads as:

Findings of elevated levels of IDO and CTLA-4 expression from the same biopsies provided additional insights into underlying mechanisms for this impaired immune function.37

In addition, the full names of Dr. Adams and Dr. Lasarte are corrected as follows: Victoria C. Adams Juan J. Lasarte

Please note that this study was also supported by grants from UTE project CIMA.

Address reprint requests to: Jonathan L. Heeney. E-mail: jhl66@cam.ac.uk

The Publisher regrets the errors.