Patricia E. Ganey and James P. Luyendyk contributed equally to this study.
Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice†
Article first published online: 25 JUL 2007
Copyright © 2007 American Association for the Study of Liver Diseases
Volume 46, Issue 4, pages 1177–1186, October 2007
How to Cite
Ganey, P. E., Luyendyk, J. P., Newport, S. W., Eagle, T. M., Maddox, J. F., Mackman, N. and Roth, R. A. (2007), Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology, 46: 1177–1186. doi: 10.1002/hep.21779
Potential conflict of interest: Nothing to report.
- Issue published online: 25 SEP 2007
- Article first published online: 25 JUL 2007
- Manuscript Accepted: 17 APR 2007
- Manuscript Received: 1 DEC 2006
- NIH. Grant Numbers: DK061315, National Research Service Award HL085983
|jws-hep.21779.fig1.pdf||40K||Suppl Fig 1: OT-I CD8 T-cells were purified from the lymph nodes of OT-I mice. 4 million cells were CFSE-labelled and transferred intravenously into ASBT-OVA or TF-OVA mice. Experiments in ASBT-OVA and TF-OVA mice were carried out simultaneously and mice received cells from the same batch of OT-I T-cells. 20 hours after transfer, cells were isolated form the livers and stained for CD8 and Va2. In (A), expression levels of CD8 and Va2 within the population of CFSE-positive (transgenic) cells are depicted. In (B), numbers of CD8+Va2+ and CFSE+ cells isolated from the livers of ASBT-OVA and TF-OVA mice are compared (n=6 each).|
|jws-hep.21779.fig2.pdf||34K||Suppl Fig 2: OT-I CD8 T-cells were purified from the lymph nodes of OT-I or OT-I RAG-/- mice. Cells isolated from OT-I mice were also selected for CD62L expression. 4 million cells were CFSE-labelled and transferred intravenously into TF-OVA (A) or ASBT-OVA mice (B). T-cells were isolated from the indicated tissues (Ing. LN. Inguinal lymph node; Liv. LN. Liver lymph node; Intrahep. Intrahepatic) at 44 hours and analyzed for the presence of proliferating transgenic T-cells by flow cytometry. Plots display data gated on CD8+Va2+ cells.|
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